Contribution of airway mucosal remodeling for secretion in the olfactory mucosa-The elucidation of the mechanism of smell dysfunction for eosinophilic sinusitis-
| Project/Area Number |
21592178
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FUKAMI Satoru 獨協医科大学, 医学部, 准教授 (00311944)
月館 利治 獨協医科大学, 医学部, 講師 (40287256)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUKIDATE Toshiharu 獨協医科大学, 医学部, 講師 (40287256)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 鼻科学 / 嗅粘膜 / 好酸球 / 分泌異常 / リモデリング / 副鼻腔炎 / 嗅覚障害 / 呼吸粘膜 / NO / amphiregulin |
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| Research Abstract |
The cases of sinusitis with olfactory dysfunction which postoperative ECP concentration decreased were found in not only postoperative good and improvement of dysosmia, but also significant decrease of respiratory NO concentration. Although severe infltration of eosinophil in the respiratory mucosa were seen, there was little infltration in olfactory mucosa. As large Boman glands were seen and positive stain of ConA and SNA were found, the increase of mucosa secretion in the olfacoty mucosa was suspected. There was little distribution of amphiregutin in the olfactory mucosa compared with that in the respiratory mucosa. Therefore, the effect of the olfactory mucosa due to the respiratory mucosal remodeling was indicated that the possibility of dysfunction of the olfactory mucosa was due to the secretory change.
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Report
(4 results)
Research Products
(34 results)
