Role of epithelial cells in the pathomechanisms of allergic rhinitis-interaction with T cells and dendritic cells
| Project/Area Number |
21592181
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Nippon Medical School |
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Principal Investigator |
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 鼻アレルギー / 上皮細胞 / 樹状細胞 / T細胞 / アレルギー性鼻炎 / TSLP |
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| Research Abstract |
TSLP expression was detected in epithelial cells and mast cells of the nasal mucosa from allergic and non allergic rhinitics and nasal polyps from atopics and non-atopics. The expression of TSLP was highest in nasal polyps from atopics as compared to allergic nasal mucosa and non-atopic nasal polyps. The expression of Th2 chemokines like TARC and MDC were also increased. Both in allergic nasal mucosa and atopic nasal polyps there was a good correlation between the TSLP+cells and IgE and TSLP+cells and eosinophils. House dust mite stimulation of nasal epithelial cells resulted in increased TSLP secretion. There was a good correlation between TSLP and CCR4+cells and CCR4+cells with IL-4 and IL-13.
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Report
(4 results)
Research Products
(17 results)
