Role of epithelial cells in the pathomechanisms of allergic rhinitis-interaction with T cells and dendritic cells

• Project/Area Number: 21592181
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Nippon Medical School
• Principal Investigator: RUBY PAWANKAR Pawankar) (RUBY Pawankar)) 日本医科大学, 医学部, 准教授 (00287674)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
• Keywords: 鼻アレルギー / 上皮細胞 / 樹状細胞 / T細胞 / アレルギー性鼻炎 / TSLP

Research Abstract

TSLP expression was detected in epithelial cells and mast cells of the nasal mucosa from allergic and non allergic rhinitics and nasal polyps from atopics and non-atopics. The expression of TSLP was highest in nasal polyps from atopics as compared to allergic nasal mucosa and non-atopic nasal polyps. The expression of Th2 chemokines like TARC and MDC were also increased. Both in allergic nasal mucosa and atopic nasal polyps there was a good correlation between the TSLP+cells and IgE and TSLP+cells and eosinophils. House dust mite stimulation of nasal epithelial cells resulted in increased TSLP secretion. There was a good correlation between TSLP and CCR4+cells and CCR4+cells with IL-4 and IL-13.

Research Products

• [Journal Article] Increased expression and role of thymic stromal lymphopoietin In nasal polyposis (2011)
  • Author(s): Kimura S, Pawankar R, et al.
  • Journal Title: Allergy Asthma Immunol Res Volume: Vol.3-3 Issue: 3 Pages: 186-186
  • DOI: 10.4168/aair.2011.3.3.186
• [Journal Article] Overview on the pathomechanisms of allergic rhinitis (2011)
  • Author(s): Pawankar R, Mori S, Ozu C, Kimura S
  • Journal Title: Asia Pac Allergy Volume: Vol.1(3) Issue: 3 Pages: 157-67
  • DOI: 10.5415/apallergy.2011.1.3.157
• [Journal Article] Synergistic induction of thymic stromal lymphopoietin by tumor necrosis factor alpha and Th2 cytokine in nasal polyp fibroblasts (2010)
  • Author(s): Nonaka M, Pawankar R, et al
  • Journal Title: Am J Rhinology and Allergy Volume: Vol.124(1) Issue: 1 Pages: 8-14
  • DOI: 10.2500/ajra.2010.24.3436
• [Journal Article] Novel inflammatory markers as targets for immunomodulation (2010)
  • Author(s): Pawankar R, et al
  • Journal Title: Monograph on Allergic diseases Volume: Vol.1 Pages: 81-89
• [Journal Article] Current concepts on the pathomechanisms of chronic rhinosinusitis and nasal polyps (2010)
  • Author(s): Pawankar R, et al
  • Journal Title: Nasal Polyps Volume: Vol.1 Pages: 185-190
  • DOI: 10.1007/978-3-642-11412-0_21
  • ISBN: 9783642114113, 9783642114120
• [Journal Article] Novel inflammatory markers as targets for immunomodulation. (2010)
  • Author(s): Pawankar R, et al
  • Journal Title: Monograph on Allergic diseases Volume: 1 Pages: 81-89
• [Journal Article] Synergistic induction of thymic stromal lymphopoietin by tumor necrosisfactor alpha and Th2 cytokine in nasal polyp fibroblasts (2010)
  • Author(s): Nonaka M, Pawankar R, et al
  • Journal Title: Am J Rhinology and Allergy Pages: 8-14
• [Journal Article] Rhinosinusitis in children and asthma severity (2009)
  • Author(s): Pawankar R, Zernotti ME
  • Journal Title: Curr Opin Allergy Clin Immunology Volume: Vol.9(2) Issue: 2 Pages: 151-153
  • DOI: 10.1097/aci.0b013e328329221d
• [Journal Article] Rhinosinusitis in children and asthma severity. (2009)
  • Author(s): Pawankar R, Zernotti ME.
  • Journal Title: Curr Opin Allergy Clin Immunology 9(2) Pages: 151-153
• [Presentation] Novel biomarkers in allergic airway disease (2012)
  • Author(s): Pawankar R, et al.
  • Organizer: Annual Conf of Malaysian Society of Allergy and Immunology
  • Place of Presentation: Kuala Lumpur, Malaysia
  • Year and Date: 2012-03-09
• [Presentation] Novel biomarkers in allergic airway disease (2012)
  • Author(s): Pawankar R, et al
  • Organizer: Annual Conf of Malaysian Society of Allergy and Immunology
  • Place of Presentation: Kuara-lumpur, Malaysia(招待講演)
  • Year and Date: 2012-03-09
• [Presentation] Increased expression of TSLP in nasal polyps and nasal mucosa (2011)
  • Author(s): Pawankar R, Kimura S, et al.
  • Organizer: 22^<nd> World Allergy Congress
  • Place of Presentation: Cancun, Mexico
  • Year and Date: 2011-12-05
• [Presentation] IgE-immune inflammation in allergic airway disease its clinical implications (2010)
  • Author(s): Pawankar R, et al.
  • Organizer: 2010 Annual meeting of the American College of Allergy Asthma and Clinical Immunology
  • Place of Presentation: Phoenix, USA
  • Year and Date: 2010-11-15
• [Presentation] IgE-immune inflammation in allergic airway disease-its clinical implications (2010)
  • Author(s): Pawankar R, et al
  • Organizer: 2010 Annual meeting of the American College of Allergy Asthma and Clinical Immunology
  • Place of Presentation: Phoenix, USA
  • Year and Date: 2010-11-15
• [Presentation] Update on pathomechanisms of allergic rhinitis-epithelial-T cell interactions (2010)
  • Author(s): Pawankar R, et al
  • Organizer: NUH-NUS Otolaryngology Head and Neck Conference-The Nose
  • Place of Presentation: Singapore
  • Year and Date: 2010-03-13
• [Presentation] Update on pathomechanisms of allergic rhinitis-epithelial? T cell interactions (2010)
  • Author(s): Pawankar R, et al.
  • Organizer: NUH-NUS Otolaryngology Head and Neck Conference-The Nose
  • Place of Presentation: Singapore
• [Presentation] Revisting the role of epithelial cell-effector cell interactions in allergic airway inflammation and remodelling (2010)
  • Author(s): Pawankar R, et al.
  • Organizer: 2010 Annual Congress Malaysian Society of Allergy and Immunology
  • Place of Presentation: Kuala Lumpur, Malaysia