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Study on thickened cell wall in clinical macrolide-resistant Staphylococcus aureus isolates.

Research Project

Project/Area Number 21592183
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Otorhinolaryngology
Research InstitutionKawasaki Medical School

Principal Investigator

YAMADA Sakuo  川崎医科大学, 医学部, 准教授 (00122458)

Co-Investigator(Kenkyū-buntansha) HARADA Tamotsu  川崎医科大学, 医学部, 教授 (30165021)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords黄色ブドウ球菌 / 細胞壁 / 肥厚 / マクロライド / ゲンタマイシン / 耐性菌 / 細胞壁肥厚 / 臨床由来耐性菌
Research Abstract

The clinical macrolide(ML)-resistant Staphylococcus aureus strains showed a thickened cell wall when compared morphologically with the clinical ML-sensitive S. aureus strains. We also demonstrated that gentamycin-resistant clinical isolates of S. aureus exhibited a thickened cell wall. These results strongly suggest that a thickened cell wall is a common ultrastractural characteristic of protein synthesis inhibitor antibiotics-resistant S. aureus clinical strains.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (31 results)

All 2012 2011 2010 2009 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results) Presentation (24 results)

  • [Journal Article] Ultrastructural cell wall characteristics of clinical gentamycin-resistant Staphylococcus aureus isolates2012

    • Author(s)
      Fukutsuji Kenji, Yamada Sakuo, Harada Tamotsu
    • Journal Title

      Medical Molecular Morphology

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Antimicrobial effects of Burrow's solution on Staphylococcus aureus and Pseudomonas aeruginosa2012

    • Author(s)
      Hyo Yoshiyuki, Yamada Sakuo, Ishimatsu Masaki, Fukutsuji Kenji, Harada Tamotsu
    • Journal Title

      Medical Molecular Morphology

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] GlmS and NagB regulate amino sugar metabolism in opposing directions and affect Streptococcus mutans virulence2012

    • Author(s)
      Kawada-Matsuo M, Mazda Y, Oogai Y, Kajiya M, Kawai T, Yamada S, Miyawaki S, Oho T, Komatsuzawa H
    • Journal Title

      PLos ONE

      Volume: (in press) Issue: 3 Pages: e33382-e33382

    • DOI

      10.1371/journal.pone.0033382

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 臨床由来マクロライド耐性ブドウ球菌の顕微科学的検索2010

    • Author(s)
      兵行義、山田作夫、原田保
    • Journal Title

      顕微鏡

      Volume: 45(4) Pages: 218-222

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 臨床由来マクロライド耐性ブドウ球菌の顕微科学的検索2010

    • Author(s)
      兵行義
    • Journal Title

      顕微鏡

      Volume: 45巻 Pages: 218-222

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antimicrobial effects of Burrow's solution on Staphylococcus aureus and Pseudomonas aeruginosa

    • Author(s)
      Hyo Yukiyoshi
    • Journal Title

      Medical Molecular Morphology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrastructural cell wall characteristics of clinical gentamycin-resistant Staphylococcus aureus isolates

    • Author(s)
      Fukutsuji Kenji
    • Journal Title

      Medical Molecular Morphology

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] The role in Staphylococcus aureus skin-infection, a novel cell wall protein Skip2012

    • Author(s)
      Hisatsune Junzo
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎市)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] GlmS and NagB modulate VicRK affecting Staphylococcus mutans virulence2012

    • Author(s)
      Kawada-Matsuo Miki
    • Organizer
      第85回日本細菌学会総会
    • Place of Presentation
      長崎ブリックホール(長崎市)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 二酸化塩素の殺芽胞作用に関する顕微科学的検索2012

    • Author(s)
      山田作夫
    • Organizer
      第27回日本環境感染学会総会
    • Place of Presentation
      福岡国際会議場(福岡市)
    • Year and Date
      2012-02-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 次亜塩素酸ナトリウムの殺芽胞作用に関する顕微科学的解析2011

    • Author(s)
      山田作夫
    • Organizer
      第59回日本化学療法学会西日本支部総会
    • Place of Presentation
      奈良県新公会堂(奈良市)
    • Year and Date
      2011-11-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] 次亜塩素酸ナトリウムおよび二酸化塩素の殺芽胞作用に関する顕微科学的検索2011

    • Author(s)
      山田作夫
    • Organizer
      日本顕微鏡学会第55回シンポジウム
    • Place of Presentation
      かがわ国際会議場(高松市)
    • Year and Date
      2011-10-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Characteristic cell wall ultrastructure of a macrolide-resistant Staphylococcus capitis strain isolated from a patient with chronic sinusitis2011

    • Author(s)
      Hyo Yukiyoshi
    • Organizer
      14th International Rhinologic Society & 30th International Symposium on Infection and Allergy of the Nose
    • Place of Presentation
      ANAインターコンチネンタルホテル東京(東京)
    • Year and Date
      2011-09-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] ゲンタマイシンの抗黄色ブドウ球菌作用に関する超微形態的解析2011

    • Author(s)
      福辻賢治
    • Organizer
      第43回日本臨床分子形態学会総会学術集会
    • Place of Presentation
      大阪医科大学(高槻市)
    • Year and Date
      2011-09-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Antiseptic susceptibility and morphological changes for metallo-beta-lactamase NDM-1 producing multidrug-resistant Escherichia coli2011

    • Author(s)
      Kawai Mako
    • Organizer
      IUMS2011 : International Union of Microbiological Societies 2011 Congress
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2011-09-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] NDM-1産生多剤耐性大腸菌の消毒薬感受性2011

    • Author(s)
      川井眞好
    • Organizer
      第59回日本化学療法学会総会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2011-06-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Possible mechanisms of cell wall thickness induced in Staphylococcus aureus by quaternary ammonium compounds of antiseptic agents2011

    • Author(s)
      Kawai Mako
    • Organizer
      111th General Meeting American Society for Microbiology
    • Place of Presentation
      New Orleans, USA
    • Year and Date
      2011-05-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ultrastractural cell wall characteristics of clinical gentamycin-resistant Staphylococcus aureus isolates2011

    • Author(s)
      Fukutsuji Kenji, Yamada Sakuo, Harada Tamotsu
    • Organizer
      21st ECCMID : 21st European Congress of Clinical Microbiology and Infectious Diseases/27th ICC : International Congress of Chemotherapy
    • Place of Presentation
      ITALIA
    • Year and Date
      2011-05-08
    • Related Report
      2011 Final Research Report
  • [Presentation] Ultrastractural cell wall characteristics of clinical gentamycin-resistant Staphylococcus aureus isolates2011

    • Author(s)
      Fukutsuji Kenji
    • Organizer
      21st ECCMID : 21st European Congress of Clinical Microbiology and Infectious Diseases/27th ICC : International Congress of Chemotherapy
    • Place of Presentation
      Milano Convention Center (Italy)
    • Year and Date
      2011-05-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 臨床由来ゲンタマイシン耐性黄色ブドウ球菌における超微形態的特徴2010

    • Author(s)
      福辻賢治
    • Organizer
      第42回日本臨床分子形態学会総会・学術総会
    • Place of Presentation
      東レ総合研修センター(静岡県)
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] ゲンタマイシン処理による黄色ブドウ球菌の超微形態変化2010

    • Author(s)
      福辻賢治
    • Organizer
      日本耳鼻咽喉科学会第36回中国四国地方部会連合学会
    • Place of Presentation
      岡山国際交流センター(岡山県)
    • Year and Date
      2010-06-05
    • Related Report
      2010 Annual Research Report
  • [Presentation] ゲンタマイシン耐性黄色ブドウ球菌臨床分離株における細菌学的特徴2010

    • Author(s)
      福辻賢治、山田作夫、兵行義、原田保
    • Organizer
      第58回日本化学療法学会総会
    • Place of Presentation
      長崎
    • Year and Date
      2010-06-03
    • Related Report
      2011 Final Research Report
  • [Presentation] ゲンタマイシン耐性黄色ブドウ球菌臨床分離株における細菌学的特徴2010

    • Author(s)
      福辻賢治
    • Organizer
      第58回日本化学療法学会総会
    • Place of Presentation
      長崎ブリックホール(長崎県)
    • Year and Date
      2010-06-03
    • Related Report
      2010 Annual Research Report
  • [Presentation] ゲンタマイシン耐性黄色ブドウ球菌臨床分離株における超微形態的特徴2010

    • Author(s)
      福辻賢治、山田作夫
    • Organizer
      日本顕微鏡学会第66回学術講演会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-05-25
    • Related Report
      2011 Final Research Report
  • [Presentation] ゲンタマイシン耐性黄色ブドウ球菌臨床分離株における超微形態的特徴2010

    • Author(s)
      福辻賢治
    • Organizer
      日本顕微鏡学会第66回学術講演会
    • Place of Presentation
      名古屋国際会議場(愛知県)
    • Year and Date
      2010-05-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] マクロライド耐性ブドウ球菌の顕微科学的解析2010

    • Author(s)
      山田作夫
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-03-29
    • Related Report
      2011 Final Research Report
  • [Presentation] マクロライド耐性ブドウ球菌の顕微科学的解析2010

    • Author(s)
      山田作夫
    • Organizer
      第83回日本細菌学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] ゲンタマイシン耐性黄色ブドウ球菌臨床分離株における超微形態的特徴2009

    • Author(s)
      山田作夫
    • Organizer
      第57回日本化学療法学会西日本支部総会
    • Place of Presentation
      名古屋国際会議場(名古屋市)
    • Year and Date
      2009-11-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 臨床由来ゲンタマイシン耐性黄色ブドウ球菌における特徴ある超微形態像2009

    • Author(s)
      山田作夫
    • Organizer
      第54回日本ブドウ球菌研究会
    • Place of Presentation
      現代医学教育博物館(倉敷市)
    • Year and Date
      2009-09-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] マクロライド耐性黄色ブドウ球菌における超微形態的特徴ならびにβラクタム薬感受性2009

    • Author(s)
      兵行義、山田作夫、原田保
    • Organizer
      第41回日本臨床分子形態学会総会・学術集会
    • Place of Presentation
      神戸
    • Year and Date
      2009-09-05
    • Related Report
      2011 Final Research Report
  • [Presentation] マクロライド耐性黄色ブドウ球菌における超微形態的特徴ならびにβラクタム感受性2009

    • Author(s)
      山田作夫
    • Organizer
      第41回日本臨床分子形態学会総会・学術集会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2009-09-05
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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