| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
We have investigated the expression of High Molecular Weight-Melanoma Associated Antigen in human head and neck squamous cell carcinoma cells, and found CSPG4 expression not only on the cell surface of HNSCC cells but also clinical samples. Moreover, we have established the scFv specific for High Molecular Weight-Melanoma Associated Antigen utilizing genetic engineering techniques. In Vivo study utilizing SCID mice xenograft model inoculated with various human malignant cell lines, our scFv specific for High Molecular Weight-Melanoma Associated Antigen clearly inhibited proliferation and metastasis of the tumor cells.
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