Invastigations on High Molecular Weight-Melanoma Associated Antigen as a target of the immunotherapy
Project/Area Number |
21592185
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Otorhinolaryngology
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Research Institution | Asahikawa Medical College |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
YOSHINO Kazumi 旭川医科大学, 耳鼻科・医学部, 医員 (60516722)
TOTANI Toshitaka 旭川医科大学, 耳鼻科・医学部, 医員 (40516720)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
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Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 頭頚部外科学 / HMW-MAA / CSPG4 / B7-H3 / 抗体療法 / 免疫療法 / 高子黒色腫抗原 / 高分子黒色腫抗原 |
Research Abstract |
We have investigated the expression of High Molecular Weight-Melanoma Associated Antigen in human head and neck squamous cell carcinoma cells, and found CSPG4 expression not only on the cell surface of HNSCC cells but also clinical samples. Moreover, we have established the scFv specific for High Molecular Weight-Melanoma Associated Antigen utilizing genetic engineering techniques. In Vivo study utilizing SCID mice xenograft model inoculated with various human malignant cell lines, our scFv specific for High Molecular Weight-Melanoma Associated Antigen clearly inhibited proliferation and metastasis of the tumor cells.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Functional characterization of an scFv-Fc antibody that immunotherapeutically targets the common cancer cell surface proteoglycan CSPG42011
Author(s)
Wang X, Katayama A, Wang Y, Yu L, Favoino E, Sakakura K, Favole A, Tsuchikawa T, Silver S, Watkins SC, Kageshita T, Ferrone S
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Journal Title
Cancer Res
Volume: 71(24)
Issue: 24
Pages: 7410-22
DOI
Related Report
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[Journal Article] Functional characterization of an scFv-Fc antibody that immunotherape utically targets the common cancer cell surface proteoglycan CSPG42011
Author(s)
Wang X, Katayama A, Wang Y, Yu L, Favoino E, Sakakura K, Favole A, Tsuchikawa T, Silver S, Watkins SC, Kageshita T, Ferrone S
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Journal Title
Cancer Res.
Volume: 24
Pages: 7410-22
Related Report
Peer Reviewed
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[Journal Article] CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer2010
Author(s)
Wang X, Osada T, Wang Y, Yu L, Sakakura K, Katayama A, McCarthy JB, Brufsky A, Chivukula M, Khoury T, Hsu DS, Barry WT, Lyerly HK, Clay TM, Ferrone S.
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Journal Title
J Natl Cancer Inst.
Volume: 102(19)
Issue: 19
Pages: 1496-512
DOI
Related Report
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