Research of the mechanism of lymph node metastasis in nasopharyngeal carcinoma with bio-assay model
| Project/Area Number |
21592189
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIZAKI Tomokazu 金沢大学, 医学系, 教授 (70262582)
MURONO Shigeyuki 金沢大学, 大学病院, 講師 (20345622)
KONDO Satoru 金沢大学, 附属病院, 助教 (70436822)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | EBV / LMP1 / VEGF-C / リンパ管新生 / リンパ節転移 / 上咽頭癌 / 動物モデル / 胸管 / 舌癌 / センチネル・リンパ節 |
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| Research Abstract |
The involvement of vascular endothelial growth factor (VEGF)-C/VEGF receptor-3 axis in the induction of lymphangiogenesis results in lymphatic spread of nasopharyngeal carcinoma. However, Epstein-Barr virus-associated latent membrane protein-1 was not associated with the mechanism.Knowing the status of lymphangiogenesis in the regional lymph nodes in tongue cancer would help in predicting which patients will develop nodal recurrence. Thus, therapeutic approach which blocks lymphangiogenic factors may be beneficial in suppressing the lymphatic spread of tongue cancer with intense intranodal lymphangiogenesis.
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Report
(5 results)
Research Products
(39 results)
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[Journal Article] Epidemiological analysis ofnasopharyngeal carcinoma in the central region of Japan during the period from 1996 to 2005.2011
Author(s)
Kimura Y, Suzuki D, Tokunaga T, Takabayashi T, Yamada T, Wakisaka N, Yoshizaki T, Murata H, Miwa K, Shoujaku H, Watanabe Y, Yamada N, Ito Y, Yuta A, Takeuchi K,Hosokawa S, Mineta H, Hasegawa Y, Fujimoto Y, Nakashima T, Fujieda S
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Journal Title
Auris Nasus Larynx
Volume: 38(2)
Issue: 2
Pages: 244-9
DOI
Related Report
Peer Reviewed
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