| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Research Abstract |
Immune reactions in head/neck cancer patients treated with protein vaccine, recombinant MAGE-A4 protein complexed with cholesteryl pullulan, were analyzed. 16 subjects including head/neck cancer patients completed 6 or more vaccination. Humoral IgG responses were analyzed with ELISA assay. 3 patients were positive for MAGE-A4 antibody prior vaccination, suggesting that there exists natural positive immunity in MAGE-A4 antigen positive cancer patients. Among them, MAGE-A4 immunity was augmented in one case. In 4 MAGE-A4 antibody negative patients, 2 converted to MAGE-A4 IgG positive. Spreading of immune reactions other than vaccinated antigen was observed.
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