| Project/Area Number |
21592194
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
TAKEDA Noriaki 徳島大学, 大学院・ヘルスバイオサイエンス研究部, 教授 (30206982)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Shigeru 十文字学園女子大学, 人間生活部, 教授 (70093896)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 味覚障害 / 亜鉛欠乏 / ACE活性比 / 亜鉛補充療法 / オリゴ糖 / 亜鉛欠乏性味覚障害 / 亜鉛吸収障害 / 亜鉛 / 血清ACE活性比 / 血清亜鉛値 |
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| Research Abstract |
We developed the ratio of apo/ holo activities of angiotensin coverting enzyme(ACR ratio) in the serum and examined patients with taste impairment and healthy subjects for their zinc nutrition using ACE ration as an index. In addition to a significant increase in ACE ratio in taste impairment patients with low concentrations of zinc in serum, ACE ratio was also significant elevated in taste impairment patients with normal value of zinc. These finding indicate that zinc deficiency is a predominant factor underlying taste impairment even when zinc concentrations are within normal ranges in serum. But, there were no differences in dietary zinc intake between patients and age-adjusted healthy subjects, suggesting that patients with taste impairment have malabsorption of dietary zinc in the gastrointestinal tract. We then examined the effects of zinc supplementation with difructose that enhances the absorption of zinc on taste impairment and showed its favorable efficacy. It is suggested that zinc supplementation with difructose will be a new treatment in patients woth refractory taste impairment.
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