Analysis of CD44 variant isoforms in head and neck squamous cell carcinoma

• Project/Area Number: 21592198
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Otorhinolaryngology
• Research Institution: Kumamoto University
• Principal Investigator: MURAKAMI Daizo 熊本大学, 医学部附属病院, 助教 (70398212)
• Co-Investigator(Kenkyū-buntansha): MINODA Ryosei 熊本大学, 大学院・生命科学研究部, 准教授 (30284772)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 頭頸部癌 / CD44 / バリアントアイソフォーム / 連続的切断 / 転写 / 浸潤・転移

Research Abstract

The expression of CD44 variant isoforms is very low in head and neck squamous cell carcinoma although the expression level of CD44s is high. Cleavage fragment of CD44 was also detected. Moreover, immunostaining of HNSCC revealed the translocation of CD44 to nucleus. This result supports our in vitro data of the sequential cleavage of CD44 and functiuon as a signal transduction molecule.