| Project/Area Number |
21592202
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Yokohama City University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KUSAKABE Tatsumi 国士舘大学, 体育学部, 教授 (80117663)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 高血圧 / 低酸素 / 化学受容器 / 特殊臓性知覚 / 組織化学 / 頸動脈小体 / ドーパミン / ノルアドレナリン / 蛍光免疫染色 / 立体画像構築 / カテコールアミン合成酵素 / 免疫組織化学 / 神経ペプチド |
|---|
| Research Abstract |
The carotid bodies, which are located at the carotid bifurcation and are the primary chemoreceptive organs for sensing changes in arterial blood gases, became significantly enlarged in spontaneously hypertensive rats(SHR). In spite of enlargement, there was no obvious vascular enlargement in SHR. SHR showed a significant increase in extracellular matrix in the carotid body. These results indicate that the mechanism of carotid body enlargement in SHR is different from that in hypoxic animals. In addition, the present studies suggest facilitated noradrenaline biosynthesis in chemoreceptor cells of carotid bodies in SHR.
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