Regulation of Wnt/Snail signal and MMP onhead and neck cancer invasion and metastasis
| Project/Area Number |
21592203
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Otorhinolaryngology
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| Research Institution | Kinki University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OHNISHI Takeo 奈良医科大学, 医学部, 教授 (60094554)
OTA Ichiro 奈良医科大学, 医学部, 助教 (00326323)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 頭頸部がん / 浸潤 / 転移 / Wnt / Snail / MMP / 浸潤・転移 |
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| Research Abstract |
We demonstrate that Wnt signaling and its downstream factor, Snail, induce cancer invasion and metastasis in vivo via a matrix metalloproteinase-dependent process, using a chick chorioallantoic membrane invasion assay(CAM invasion assay). Furthermore, siRNA-specific silencing of Snail ablates the ability of cancer invasion and metastasis. Taken together, these data suggest that Snail1-targeted therapy could be effective to cancer invasion and metastasis.
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Report
(4 results)
Research Products
(31 results)
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[Journal Article] siRNA targeted for NBS1 enhances heat sensitivity in human anaplastic thyroid carcinoma cells2011
Author(s)
Okamoto N, Takahashi A, Ota I, Ohnishi K, Mori E, Kondo N, Noda T, Nakagawa Y, Uemura H, Yane K, Hosoi H, Ohnishi T
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Journal Title
Int J Hyperthermia
Volume: 27
Pages: 297-304
Related Report
Peer Reviewed
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