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EFFECTS OF THE ARMS2 GENE POLYMORPHISM ON CLINICAL FEATURES OF RETINITIS PIGMENTOSA

Research Project

Project/Area Number 21592213
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionHirosaki University

Principal Investigator

NAKAZAWA Mitsuru  弘前大学, 大学院・医学研究科, 教授 (80180272)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords臨床 / 眼科学 / 遺伝性網膜変性 / 網膜色素変性 / 加齢黄斑変性 / 視細胞 / アポトーシス / ARMS1遺伝子 / ミトコンドリア
Research Abstract

I studied the effects of the ARMS2 gene polymorphism, which was known to be related to age-related macular degeneration, on the clinical severities of retinitis pigmentosa to clarify whether this polymorphism also might act as a modifier of retinitis pigmentosa. Under the approval of the committee of ethics for clinical study of Hirosaki University, I analyzed the ARMS2 polymorphism of the patients with retinitis pigmentosa at the Hirosaki University Hospital, and examined the relationship between the types of the ARMS2 polymorphism (Ala69Ser) and progression of visual field constriction evaluated by the MD slope of Humphry's 10-2 program. The results obtained revealed that there was no co-relationship between ARMS2 polymorphisms and MD slopes. These results suggest that the ARMS2 polymorphism (Ala69Ser) may not play as a modifier of the central visual field constriction in patients with retinitis pigmentosa.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (60 results)

All 2012 2011 2010 2009 Other

All Journal Article (44 results) (of which Peer Reviewed: 35 results) Presentation (13 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] M-opsin protein degradation is inhibited by MG-132 in RPE65^<-/-> retinal explant2012

    • Author(s)
      Sato K, Ozaki T, Ishiguro S, Nakazawa M
    • Journal Title

      Mol Vis

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 涙液.眼科医にも分かる生理活性物質と眼疾患の基礎262012

    • Author(s)
      中澤満
    • Journal Title

      臨床眼科

      Volume: 66(2) Pages: 156-159

    • Related Report
      2011 Final Research Report
  • [Journal Article] 角膜上皮創傷治癒.眼科医にも分かる生理活性物質と眼疾患の基礎262012

    • Author(s)
      中澤満
    • Journal Title

      臨床眼科

      Volume: 66(3) Pages: 250-253

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effect of nilvadipine on central visual field in retinitis pigmentosa : a 30-month clinical trial2011

    • Author(s)
      Nakazawa M, Ohguro H, Takeuchi K, 4Miyagawa Y, Ito T, Metoki T
    • Journal Title

      Ophthalmologica

      Volume: 225 Pages: 120-126

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Solid Hyaluronic Acid Film on Postoperative Fibrous Scar Formation after Strabismus Surgery in Animals2011

    • Author(s)
      Takeuchi K, Nakazawa M, Metoki T, Yamazaki H, Miyagawa Y, Ito T
    • Journal Title

      J Pediat Ophth Strab

      Volume: 48 Pages: 301-304

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion2011

    • Author(s)
      Suzuki Y, Nakazawa M, Suzuki K, Yamazaki H, Miyagawa Y
    • Journal Title

      Jpn J Ophthalmol

      Volume: 55 Pages: 256-263

    • NAID

      10029021378

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of trehalose on VEGF-stimulated angiogenesis and myofibroblast proliferation. Implication for glaucoma filtration surgery2011

    • Author(s)
      Takeuchi K, Nakazawa M, Ebina Y
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52(9) Pages: 6987-6993

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel compound heterogenous mutation in the CYP4V2 gene in a Japanese patient with Bietti's crystalline corneoretinal dystrophy2011

    • Author(s)
      Yokoi Y, Sato K, Aoyagi H, Takahashi Y, Yamagami M, Nakazawa M
    • Journal Title

      Case Reports in Ophthalmology

      Volume: 2 Issue: 3 Pages: 296-301

    • DOI

      10.1159/000331885

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of calcium ion, calpains and calcium channel blockers on retinitis pigmentosa2011

    • Author(s)
      Nakazawa M
    • Journal Title

      J. Ophthalmol

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 硝子体手術を行って視神経乳頭マッサージを試みた網膜中心動脈閉塞症の1例2011

    • Author(s)
      伊藤忠、鈴木幸彦、竹内侯雄、横井由美子、木村智美、山崎仁志、中澤満、吉田恒一
    • Journal Title

      臨床眼科

      Volume: 65(1) Pages: 91-95

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] CNTF.眼科医にも分かる生理活性物質と眼疾患の基礎152011

    • Author(s)
      竹内侯雄、中澤満
    • Journal Title

      臨床眼科

      Volume: 65 Pages: 276-278

    • Related Report
      2011 Final Research Report
  • [Journal Article] 錐体(杆体)ジストロフィ2011

    • Author(s)
      中澤満
    • Journal Title

      あたらしい眼科

      Volume: 28(7) Pages: 913-919

    • NAID

      10029525731

    • Related Report
      2011 Final Research Report
  • [Journal Article] 網膜色素変性.眼科医にも分かる生理活性物質と眼疾患の基礎212011

    • Author(s)
      中澤満
    • Journal Title

      臨床眼科

      Volume: 65(9) Pages: 1394-1397

    • Related Report
      2011 Final Research Report
  • [Journal Article] 緑内障濾過手術.眼科医にも分かる生理活性物質と眼疾患の基礎222011

    • Author(s)
      中澤満
    • Journal Title

      臨床眼科

      Volume: 65(10) Pages: 1572-1575

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effects of Solid Hyaluronic Acid Film on Postoperative Fibrous Scar Formation after Strabismus Surgery in Animals2011

    • Author(s)
      Takeuchi K, Nakazawa M, et al.
    • Journal Title

      Journal of Pediatric Ophthalmology & Strabismus

      Volume: 48 Pages: 301-304

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Expression profiles of cytokines and chemokines in vitreous fluid in diabetic retinopathy and central retinal vein occlusion2011

    • Author(s)
      Suzuki Y, Makazawa M., et al.
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 55 Pages: 256-263

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of trehalose on VEGF-stimulated angiogenesis and myofibroblast proliferation. Implication for glaucoma filtration surgery2011

    • Author(s)
      Takeuchi K, Nakazawa, M, Ebina Y
    • Journal Title

      Investigative Ophthalmology $ Visual Science

      Volume: 52 Pages: 6987-6993

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of nilvadipine on central visual field in retinitis pigmento sa : a 30-month clinical trial.2011

    • Author(s)
      Nakazawa M, Ohguro H, Takeuchi K, et al.
    • Journal Title

      Ophthalmologica

      Volume: 225 Pages: 120-126

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of calcium ion, calpains and calcium channel blockers on retinitis pigmentosa.2011

    • Author(s)
      Nakazawa, M
    • Journal Title

      Journal of Ophthalmology

      Volume: 2011 Article ID 2920-40

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal nevus syndrome associated with anterior scleral staphyloma and ectopic bone and cartilaginous intraocular tissue2010

    • Author(s)
      Miyagawa Y, Nakazawa M, Kudoh T
    • Journal Title

      Jpn J Ophthalmol

      Volume: 54 Pages: 15-18

    • NAID

      10027203311

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Crystal Deposits on the Lens Capsules in Bietti Crystalline Corneoretinal Dystrophy with a mutation in the CYP4V2 Gene2010

    • Author(s)
      Yokoi Y, Nakazawa M, Sato K, Mizukoshi S, Takeuchi K
    • Journal Title

      Acta Ophthalmol

      Volume: 88(5) Pages: 607-609

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression profile of intravitreous cytokines, chemokines and growth factors in patients with Fuchs heterochromic iridocyclitis2010

    • Author(s)
      Suzuki K, Suzuki Y, Matsumoto M, Nakazawa M
    • Journal Title

      Case Rep Ophthalmol

      Volume: 1 Pages: 5-13

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] S-opsin protein is incompletely modified during N-glycan processing in Rpe65-/-mice2010

    • Author(s)
      Sato K, Nakazawa M, Takeuchi K, Mizukoshi S, Ishiguro S
    • Journal Title

      Exp Eye Res

      Volume: 91(1) Pages: 54-62

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory effects of trehalose on fibroblast proliferation and implications for ocular surgery2010

    • Author(s)
      Takeuchi K, Nakazawa M, Ebina Y, Sato K, Metoki T, Miyagawa Y
    • Journal Title

      Exp Eye Res

      Volume: 91(5) Pages: 567-577

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Activation of mitochondrial calpain and release of apoptosis-inducing factor from mitochondria in RCS rat retinal degeneration2010

    • Author(s)
      Mizukoshi S, Nakazawa M, Sato K, Ozaki T, Metoki T, Ishiguro S
    • Journal Title

      Exp Eye Res

      Volume: 91 Pages: 353-361

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinicopathological roles of aberrantly expressed recoverin in malignant tumor cells2010

    • Author(s)
      Matsuo S, Ohguro H, Ohguro I, Nakazawa M
    • Journal Title

      Ophthalmic Res

      Volume: 43 Pages: 139-144

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Low levels of plasma endothelin-1 in patients with retinitis pigmentosa2010

    • Author(s)
      Ohguro H, Mashima Y, Nakazawa M
    • Journal Title

      Clin Ophthalmol

      Volume: 4 Pages: 569-573

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphological findings of intraocular lens with haptics detached from optics following cataract surgery2010

    • Author(s)
      Suzuki Y, Suzuki K, Metoki T, Nakazawa M
    • Journal Title

      Ophthalmic Surgery, Lasers & Imaging

      Volume: 9 Pages: 1-3

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 日本網膜硝子体学会:眼内長期滞留ガス(SF_6,C_3F_8)使用ガイドライン2010

    • Author(s)
      大路正人、小椋祐一郎、坂本泰二、白神史雄、平形明人、寺崎浩子、東範行、飯島裕幸、飯田知弘、池田恒彦、石橋達朗、岸章治、竹内忍、中澤満、根木昭、堀貞夫、堀口正之、松村美代、山下英俊、山本修一、湯澤美都子、吉田晃、村長久
    • Journal Title

      日眼会誌

      Volume: 114(2) Pages: 110-115

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] トラボプロスト点眼液の点状表層角膜症に対する影響2010

    • Author(s)
      山崎仁志、宮川靖博、目時友美、鈴木香、伊藤忠、横井由美子、木村智美、中澤満
    • Journal Title

      あたらしい眼科

      Volume: 27(8) Pages: 1123-1126

    • NAID

      10027747814

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] タフルプロスト片眼トライアルによる短期眼圧下降効果2010

    • Author(s)
      宮川靖博、山崎仁志、中澤満
    • Journal Title

      あたらしい眼科

      Volume: 27(7) Pages: 967-969

    • NAID

      10027747807

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 駆逐性出血に対する待機硝子体出血2010

    • Author(s)
      鈴木香、鈴木幸彦、中澤満
    • Journal Title

      臨床眼科

      Volume: 64(9) Pages: 1619-1624

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 真菌性眼窩先端症候群との鑑別に苦慮した肥厚性硬膜炎の1例2010

    • Author(s)
      鈴木香、鈴木幸彦、横井由美子、宮川靖博、目時友美、山崎仁志、中澤満
    • Journal Title

      日眼会誌

      Volume: 114(8) Pages: 687-691

    • NAID

      10026601116

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] いま注目される生理活性物質.眼科医にも分かる生理活性物質と眼疾患の基礎2010

    • Author(s)
      中澤満
    • Journal Title

      臨床眼科

      Volume: 64 Pages: 24-26

    • Related Report
      2011 Final Research Report
  • [Journal Article] 臨床から基礎研究へ、そして基礎研究から臨床へ.基礎研究から難治性眼疾患のブレークスルーをねらえ2010

    • Author(s)
      中澤満
    • Journal Title

      臨床眼科

      Volume: 64 Pages: 1955-1959

    • Related Report
      2011 Final Research Report
  • [Journal Article] Effects of Solid Hyaluronic Acid Film on Postoperative Fibrous Scar Formation after Strabismus Surgery in Animals.2010

    • Author(s)
      Takeuchi K, Nakazawa M, M etoki T, et al.
    • Journal Title

      J Pediat Ophth Strab.

      Volume: (印刷中(web上で公開))

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epidermal nevus syndrome associated with anterior scleral staphyloma and ectopic bone and cartilaginous intraocular tissue.2010

    • Author(s)
      Miyagawa Y, Nakazawa M, et al.
    • Journal Title

      Japanese Journal of Ophthalmology 54

      Pages: 15-18

    • NAID

      10027203311

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Solid hyaluronic acid prevents postoperative fibrous scar formation in experimental animal eyes2009

    • Author(s)
      Takeuchi K, Nakazawa M, Yamazaki H, Miyagawa Y, Ito T, Ishikawa F, Metoki T
    • Journal Title

      Arch Ophthalmol

      Volume: 127 (4) Pages: 460-464

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 各種緑内障手術の成績2009

    • Author(s)
      木村智美、石川太、山崎仁志、目時友美、伊藤忠、竹内侯雄、中澤満
    • Journal Title

      あたらしい眼科

      Volume: 26(9) Pages: 1279-1285

    • NAID

      10026256368

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 白内障術後に多発性網膜裂孔がみつかったWagner病の1家系2009

    • Author(s)
      鈴木香、鈴木幸彦、中澤満
    • Journal Title

      臨床眼科

      Volume: 63 Pages: 1673-1676

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 内境界膜自然剥離を伴った黄斑円孔症例2009

    • Author(s)
      伊藤忠、山崎仁志、横井由美子、目時友美、竹内侯雄、木村智美、中澤満、楠美智己
    • Journal Title

      あたらしい眼科

      Volume: 26(12) Pages: 1693-1696

    • NAID

      10026923740

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 網膜色素変性診療をめぐる3つのギャップ2009

    • Author(s)
      中澤満
    • Journal Title

      臨床眼科

      Volume: 63 Pages: 1051-1055

    • NAID

      40016767138

    • Related Report
      2011 Final Research Report
  • [Journal Article] Crystal Deposits on the Lens Capsules in Bietti Crystalline Corneoretinal Dystrophy with a mutation in the CYP4V2 Gene2009

    • Author(s)
      Yokoi Y, Nakazawa, M, et al.
    • Journal Title

      Acta Ophthalmologica (印刷中)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Solid hyaluronic acid prevents postoperative fibrous scar formation in experimental animal eyes2009

    • Author(s)
      Takeuchi K, Nakazawa M, et al.
    • Journal Title

      Archives of Ophthalmology 127

      Pages: 460-464

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規ミトコンドリアカルパイン阻害ペプチドによるアポトーシス抑制2011

    • Author(s)
      中澤満、尾崎拓、山下哲郎、石黒誠一
    • Organizer
      第31回日本眼薬理学会
    • Place of Presentation
      ホテル一畑.松江市
    • Year and Date
      2011-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] 視細胞保護の分子薬理2011

    • Author(s)
      中澤満
    • Organizer
      第31回日本眼薬理学会ランチョンセミナー
    • Place of Presentation
      ホテル一畑.松江市
    • Year and Date
      2011-09-18
    • Related Report
      2011 Final Research Report
  • [Presentation] RPE65遺伝子異常による錐体変性機序2011

    • Author(s)
      中澤満
    • Organizer
      第13回Japan Macula Club
    • Place of Presentation
      蒲郡プリンスホテル.蒲郡市
    • Year and Date
      2011-08-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Rpe65-/-マウスにおけるM-オプシンの分解機構と9-シス-レチナールによる分解抑制2011

    • Author(s)
      中澤満、佐藤孝太、石黒誠一
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム、東京
    • Year and Date
      2011-05-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Rpe65-/-マウスにおけるM-オプシンの分解機構と9-シスーレチナールによる分解抑制2011

    • Author(s)
      中澤満、佐藤孝太、石黒誠一
    • Organizer
      第115回 日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム
    • Year and Date
      2011-05-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 網膜色素変性の臨床と病態2011

    • Author(s)
      中澤満
    • Organizer
      第142回和歌山眼科学会
    • Place of Presentation
      ホテルグランビア和歌山、和歌山市
    • Year and Date
      2011-04-10
    • Related Report
      2011 Final Research Report
  • [Presentation] ニルバジピンの網膜色素変性の中心視野進行への影響2010

    • Author(s)
      中澤満、大黒浩、山崎仁志、目時友美、伊藤忠、竹内侯雄、横井由美子
    • Organizer
      第64回日本臨床眼科学会総会
    • Place of Presentation
      神戸国際会議場.神戸市
    • Year and Date
      2010-11-12
    • Related Report
      2011 Final Research Report
  • [Presentation] ニルバジピンの網膜色素変性の中心視野進行への影響2010

    • Author(s)
      中澤満、伊藤忠, ほか
    • Organizer
      第64回日本臨床眼科学会総会
    • Place of Presentation
      神戸国際会議場(神戸市)
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 網膜色素変性の考え方と最近の進歩2010

    • Author(s)
      中澤満
    • Organizer
      第6回網脈絡膜変性フォーラム
    • Place of Presentation
      盛岡市
    • Year and Date
      2010-10-10
    • Related Report
      2011 Final Research Report
  • [Presentation] RPE65ノックアウトによる錐体オプシンの不安定化2010

    • Author(s)
      中澤満
    • Organizer
      第12回Japan Macula Club
    • Place of Presentation
      蒲郡プリンスホテル
    • Year and Date
      2010-08-23
    • Related Report
      2011 Final Research Report
  • [Presentation] ニルバジピンの網膜色素変性に対する進行遅延効果2009

    • Author(s)
      中澤満、大黒浩、山崎仁志、目時友美、伊藤忠、竹内侯雄、横井由美子
    • Organizer
      第63回日本臨床眼科学会総会
    • Place of Presentation
      福岡国際会議場、福岡市
    • Year and Date
      2009-10-09
    • Related Report
      2011 Final Research Report
  • [Presentation] RCSラット網膜変性に対するミトコンドリアカルパインの関与とその制御の時間効果2009

    • Author(s)
      中澤満、水越小百合、佐藤孝太、目時友美、石黒誠一
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム.東京
    • Year and Date
      2009-04-16
    • Related Report
      2011 Final Research Report
  • [Presentation] RCSラット網膜変性に対するミトコンドリアカルパインの関与とその制御の時間効果2009

    • Author(s)
      中澤満、目時友美, 他
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.med.hirosaki-u.ac.jp/~ophthal/

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] トレハロースを用いた血管内皮細胞増殖抑制剤、点眼薬および増殖抑制方法2010

    • Inventor(s)
      中澤満、竹内侯雄、蝦名祐一
    • Industrial Property Rights Holder
      弘前大学、中澤満、竹内侯雄、蝦名祐一
    • Industrial Property Number
      2010-071135
    • Filing Date
      2010-03-25
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 結膜下線維芽組胞増殖抑制剤および結膜下線維芽細胞増殖抑制方法2009

    • Inventor(s)
      中澤満
    • Industrial Property Rights Holder
      弘前大学
    • Industrial Property Number
      2009-181976
    • Filing Date
      2009-08-04
    • Related Report
      2010 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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