| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
I studied the effects of the ARMS2 gene polymorphism, which was known to be related to age-related macular degeneration, on the clinical severities of retinitis pigmentosa to clarify whether this polymorphism also might act as a modifier of retinitis pigmentosa. Under the approval of the committee of ethics for clinical study of Hirosaki University, I analyzed the ARMS2 polymorphism of the patients with retinitis pigmentosa at the Hirosaki University Hospital, and examined the relationship between the types of the ARMS2 polymorphism (Ala69Ser) and progression of visual field constriction evaluated by the MD slope of Humphry's 10-2 program. The results obtained revealed that there was no co-relationship between ARMS2 polymorphisms and MD slopes. These results suggest that the ARMS2 polymorphism (Ala69Ser) may not play as a modifier of the central visual field constriction in patients with retinitis pigmentosa.
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