Development of devices for retinal protection

• Project/Area Number: 21592214
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Tohoku University
• Principal Investigator: ABE Toshiaki 東北大学, 大学院・医学系研究科, 教授 (90191858)
• Co-Investigator(Kenkyū-buntansha): NAGAI Nobuhiro 東北大学, 大学院・医学系研究科, 助教 (30400039) ; KAJI Kazuhiro 東北大学, 大学院・工学研究科, 助教 (70431525)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 網膜保護 / デバイス / ドラックデリバリーシステム / 新生血管 / コラーゲン / PEG / ドラッグデリバリーシステム

Research Abstract

We aimed the creation of a new device that secretes a drug for retinal protection and suppresion of choraidal neovascularization (CNV). We also aimed the sustained delivery of the drug, safety of the device and easily to be taken out the devices.
The devices were made from a sustained-release film and the reservoir using triethylene glycol dimethacrylate (TEGDM), polyethylene glycol dimethacrylate (PEGDM), and collagen particles with UV irradiation. When we used vasohibin-1 for the loaded drug in the devices, the released vasohibin-1 was found to inhibit the proliferation of endothelial cells (HUVEC)in vitro. We put the device on rat sclera and examined for a rat model of CNV using intense photocoagulation, and the effect was considered significantly when compared to that of non-vasohibin releasing device by fluorescein photography and measurement of the CNV area. Fabrication of the device can make the results exactly the sustained release of drug. We may be abe to use the device from transscleral drug delivery one for retinal diseases.

Research Products

• [Journal Article] Vasohibin-1 and retinal pigment epithelium (2012)
  • Author(s): Ishikawa Y, Nagai N, Onami H, Kumasaka N, Wakusawa R, Sonoda H, Sato Y, Abe T
  • Journal Title: Adv Med Exp Biol
  • Peer Reviewed
• [Journal Article] Reduction of laser-induced choroidal neovascularization by intravitreal vasohibin-1 in monkey eyes (2012)
  • Author(s): Onami H, Nagai N, Machida S, Kumasaka N, Wakusawa R, Ishikawa Y, Sonoda H, Sato Y, Abe T
  • Journal Title: RETINA
  • Peer Reviewed
• [Journal Article] A scalable controlled release device for transscleral drug delivery to the retina (2011)
  • Author(s): Kawashima T, Nagai N, Kaji H, Kumasaka N, Onami H, Ishikawa Y, Osumi N, Nishizawa M, and Abe T
  • Journal Title: Biomaterials Volume: 32(7) Pages: 1950-1956
  • Peer Reviewed
• [Journal Article] Fixating Dislocated Intraocular Lens by 25-Gauge Vitrectomy (2011)
  • Author(s): Kunikata H, Fuse N, Abe T
  • Journal Title: Ophthalmic Surgery, Lasers & Imaging Volume: 42(4) Pages: 297-301
  • Peer Reviewed
• [Journal Article] Nishida K Successful outcomes of 25-and 23-gauge vitrectomies for giant retinal tear detachments (2011)
  • Author(s): Kunikata H, Abe T, Nishida K
  • Journal Title: Ophthalmic Surgery, Lasers & Imaging Volume: 8 Pages: 1-6
  • Peer Reviewed
• [Journal Article] Nishida K Difficulty in Inserting 25-and 23-gauge Trocar-cannula during Vitrectomy (2011)
  • Author(s): Kunikata H Nitta F, Meguro Y, Aizawa N, Hariya T, Chiba N, Abe T, Nishida K
  • Journal Title: Ophthalmologica Pages: 198-204
  • Peer Reviewed
• [Journal Article] Enzymatic biofuel cells designed for direct power generation from biofluids in living organisms (2011)
  • Author(s): Miyake T, Haneda K, Nagai N, Yatagawa Y, Ohnami H, Yoshino S, Abe T, and Nishizawa M
  • Journal Title: Energy & Environmental Science Pages: 5008-5012
  • Peer Reviewed
• [Journal Article] Suppression of Choroidal Neovascularization by Vasohibin-1, Vascular Endothelium-derived Angiogenic Inhibitor (2011)
  • Author(s): Wakusawa R, Abe T, Sato H, Sonoda H, Sato M, Mitsuda Y, Takakura T, Fukushima T, Onami H, Nagai N, Ishikawa Y, Nishida K, and Sato Y
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 17 ; 52(6) Pages: 3272-3280
  • Peer Reviewed
• [Journal Article] Suppression of phagocytic cells in retinal disorders using amphiphilic poly(γ-glutamic acid)nanoparticles containing dexamethasone (2011)
  • Author(s): Ryu M, Nakazawa T, Akagi T, Tanaka T, Watanabe R, Yasuda M, Himori N, Maruyama K, Yamashita T, Abe T, Akashi M, Nishida K
  • Journal Title: J Control Release Volume: 151(1) Pages: 65-73
  • Peer Reviewed
• [Journal Article] Polymorphisms in ARMS2 (LOC387715)and LOXL1 Genes in Japanese with Age-related Macular Degeneration (2011)
  • Author(s): Fuse N, MingGe Mengkegale, Miyazawa A, Abe T, Nakazawa T, Wakusawa R and Nishida K
  • Journal Title: Am J Ophthalmol Volume: 151 Pages: 550-556
  • Peer Reviewed
• [Journal Article] Heat shock protein 70 (HSP70)is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase (2011)
  • Author(s): Kayama M, Nakazawa T, Thanos A, Morizane Y, Murakami Y, Theodoropoulou S, Abe T, Vavvas D and Miller JW
  • Journal Title: Am J Pathol Volume: 178(3) Pages: 1080-1091
  • Peer Reviewed
• [Journal Article] Preoperative factors predictive of postoperative decimal visual acuity > 1. 0 following surgical treatment for idiopathic epiretinal membrane (2011)
  • Author(s): Kunikata H, Abe T, Kinukawa J, Nishida K
  • Journal Title: Clinical Ophthalmology Volume: 5 Pages: 147-154
  • Peer Reviewed
• [Journal Article] A microfluidic-based neurotoxin concentration gradient for the generation of an in vitro model of Parkinson's disease (2011)
  • Author(s): Seidi A, Kaji H, Annabi N, Ostrovidov S, Ramalingam M, Khademhosseini A
  • Journal Title: Biomicrofluidics Volume: 5 Pages: 22214-22214
  • Peer Reviewed
• [Journal Article] Directed assembly of cell-laden microgels for building porous three-dimensional tissue constructs (2011)
  • Author(s): Yanagawa F, Kaji H, Jang YH, Bae H, Yanan D, Fukuda J, Qi H, Khademhosseini A
  • Journal Title: J. Biomed. Mater. Res. A 97A Pages: 93-102
  • Peer Reviewed
• [Journal Article] Engineering systems for the generation of patterned co-cultures for controlling cell-cell interactions (2011)
  • Author(s): Kaji H, Camci-Unal G, Langer R, Khademhosseini A
  • Journal Title: Biochim. Biophys. Acta-Gen. Subj Volume: 1810 Pages: 239-250
  • Peer Reviewed
• [Journal Article] A scalable controlled release device for transscleral drug delivery to the retina (2011)
  • Author(s): Kawashima T, Nagai N, Kaji H, Kumasaka N, Onami H, Ishikawa Y, Osumi N, Nishizawa M, Abe T
  • Journal Title: Biomaterials Volume: 32 Issue: 1 Pages: 1950-1956
  • DOI: 10.1016/j.jconrel.2010.11.006
  • Peer Reviewed
• [Journal Article] Suppression of Choroidal Neovascularization by Vasohibin-1, Vascular Endothelium-derived Angiogenic Inhibitor (2011)
  • Author(s): Wakusawa R, Abe T, Sato H, Sonoda H, Sato M, Mitsuda Y, Takakura T, Fukushima T, Onami H, Nagai N, Ishikawa Y, Nishida K, Sato Y
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Issue: 6 Pages: 3272-3280
  • DOI: 10.1167/iovs.10-6295
  • Peer Reviewed
• [Journal Article] Fixating Dislocated Intraocukar Lens by 25-Gauge Vitrectomy (2011)
  • Author(s): Kunikata H, Fuse N, Abe T
  • Journal Title: Ophthalmic Surgery, Lasers & Imaging Volume: 42 Issue: 4 Pages: 297-301
  • DOI: 10.3928/15428877-20110505-02
  • Peer Reviewed
• [Journal Article] Successful outcomes of 25- and 23-gauge vitrectomies for giant retinal tear detachments (2011)
  • Author(s): Kunikata H, Abe T, Nishida K
  • Journal Title: Ophthalmic Surgery, Lasers & Imaging Volume: 42 Issue: 6 Pages: 487-492
  • DOI: 10.3928/15428877-20110901-01
  • Peer Reviewed
• [Journal Article] Difficulty in Inserting 25-and 23-gauge Trocar-cannula during Vitrectomy (2011)
  • Author(s): Kunikata H, Nitta F, Meguro Y, Aizawa N, Hariya T, Chiba N, Abe T, Nishida K
  • Journal Title: Ophthalmologica Volume: 226 Issue: 4 Pages: 198-204
  • DOI: 10.1159/000330745
  • Peer Reviewed
• [Journal Article] Enzymatic biofuel cells designed for direct power generation from biofluids in living organisms (2011)
  • Author(s): Miyake T, Haneda K, Nagai N, Yatagawa Y, Ohnami H, Yoshino S, Abe T, Nishizawa M
  • Journal Title: Energy & Environmental Science Volume: 4 Issue: 12 Pages: 5008-5012
  • DOI: 10.1039/c1ee02200h
  • Peer Reviewed
• [Journal Article] Suppression of phagocytic cells in retinal disorders using amphiphilic poly (γ-glutamic acid) nanoparticles containing dexamethasone (2011)
  • Author(s): Ryu M, Nakazawa T, Akagi T, Tanaka T, Watanabe R, Yasuda M, Himori N, Maruyama K, Yamashita T, Abe T, Akashi M, Nishida K
  • Journal Title: J Control Release Volume: 151 Issue: 1 Pages: 65-73
  • DOI: 10.1016/j.jconrel.2010.11.029
  • Peer Reviewed
• [Journal Article] Polymorphisms in ARMS2 (LOC387715) and LOXL1 Genes in Japanese with Age-related Macular Degeneration (2011)
  • Author(s): Fuse N, Mengkegale M, Miyazawa A, Abe T, Nakazawa T, Wakusawa R, Nishida K
  • Journal Title: Am J Ophthalmol Volume: 151 Issue: 3 Pages: 550-556
  • DOI: 10.1016/j.ajo.2010.08.048
  • Peer Reviewed
• [Journal Article] Heat shock protein 70 (HSP70) is critical for the photoreceptor stress response after retinal detachment via modulating anti-apoptotic Akt kinase (2011)
  • Author(s): Kayama M, Nakazawa T, Thanos A, Morizane Y, Murakami Y, Theodoropoulos S, Abe T, Vavvas D, Miller JW
  • Journal Title: Am J Ophthalmol Volume: 178 Issue: 3 Pages: 1080-1091
  • DOI: 10.1016/j.ajpath.2010.11.072
  • Peer Reviewed
• [Journal Article] Preoperative factors predictive of postoperative decimal visual acuity>1.0 following surgical treatment for idiopathic epiretinal membrane (2011)
  • Author(s): Kunikata H, Abe T, Kinukawa J, Nishida K
  • Journal Title: Clinical Ophthalmology Volume: 5 Pages: 147-154
  • DOI: 10.2147/opth.s15848
  • Peer Reviewed
• [Journal Article] Exploring the role of HSP70 in retinal detachment. (2011)
  • Author(s): Takeaki Kawashima, Nobuhiro Nagai, Hirokazu Kaji, Norihiro Kumasaka, Hideyuki Onami, Yumi Ishikawa, Noriko Osumi, Matsuhiko Nishizawa, Toshiaki Abe
  • Journal Title: Am J Pathol Volume: 178 Pages: 1080-1091
  • Peer Reviewed
• [Journal Article] Suppression of Choroidal Neovascularization by Vasohibin-1, Vascular Endothelium-derived Angiogenic Inhibitor (2011)
  • Author(s): Ryosuke Wakusawa, Toshiaki Abe, Hajime Sato, Hikaru Sonoda, Masaaki Sato, Yuuichi Mitsuda, Tomoaki Takakura, Tomi Fukushima, Hideyuki Onami, Nobuhiro Nagai, Yumi Ishikawa, Kohji Nishida, Yasufumi Sato
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 未定(印刷中)
  • Peer Reviewed
• [Journal Article] Suppression of phagocytic cells in retinal disorders using amphiphilic poly(γ-glutamic acid)nanoparticles containing dexamethasone. (2011)
  • Author(s): Ryu M, Nakazawa T, Akagi T, Tanaka T, Watanabe R, Yasuda M, Himori N, Maruyama K, Yamashita T, Abe T, Akashi M, Nishida K.
  • Journal Title: J Control Release Volume: 未定(印刷中)
  • Peer Reviewed
• [Journal Article] Evaluation of retinal degeneration in P27KlP1 null mice (2010)
  • Author(s): Tokita-Ishikawa Y, Wakusawa R, Abe T
  • Journal Title: Adv Exp Med Biol Volume: 664 Pages: 467-471
  • Peer Reviewed
• [Journal Article] Preparation and characterization of collagen microspheres for sustained release of VEGF (2010)
  • Author(s): Nagai N, Kumasaka N, Kawashima T, Kaji H, Nishizawa M, Abe T
  • Journal Title: J Mater Sci Mater Med Volume: 21(6) Pages: 1891-1898
  • Peer Reviewed
• [Journal Article] Patterned differentiation of individual embryoid bodies in spatially organized 3D hybrid microgels (2010)
  • Author(s): Qi H, Du Y, Wang L, Kaji H, Bae H, Khademhosseini A
  • Journal Title: Adv. Mater Volume: 22 Pages: 5276-5281
  • Peer Reviewed
• [Journal Article] Monitoring impedance changes associated with motility and mitosis of a single cell (2010)
  • Author(s): Ghenim L, Kaji H, Hoshino Y, Ishibashi T, Haguet V, Gidrol X, Nishizawa M
  • Journal Title: Lab Chip Volume: 10 Pages: 2374-2379
  • Peer Reviewed
• [Journal Article] Electrically induced contraction of C2C12 myotubes cultured on a porous membrane-based substrate with muscle tissue-like stiffness (2010)
  • Author(s): Kaji H, Ishibashi T, Nagamine K, Kanzaki M, Nishizawa M
  • Journal Title: Biomaterials Volume: 31 Pages: 6981-6986
  • Peer Reviewed
• [Journal Article] Directing the flow of medium in controlled cocultures of HeLa cells and human umbilical vein endothelial cells with a microfluidic device (2010)
  • Author(s): Kaji H, Yokoi T, Kawashima T, Nishizawa M
  • Journal Title: Lab Chip Volume: 10 Pages: 2374-2379
  • Peer Reviewed
• [Journal Article] Electrodes combined with an agarose stamp for addressable micropatterning (2010)
  • Author(s): Sekine S, Nakanishi S, Miyake T, Nagamine K, Kaji H, Nishizawa M
  • Journal Title: Langmuir Volume: 26 Pages: 11526-11529
  • Peer Reviewed
• [Journal Article] Micropatterning Contractile C2C12 Myotubes Embedded in a Fibrin Gel (2010)
  • Author(s): Nagamine K, Kawashima T, Ishibashi T, Kaji H, Kanzaki M, Nishizawa M
  • Journal Title: Biotechnol. Bioeng Volume: 105 Pages: 1161-1167
  • Peer Reviewed
• [Journal Article] Transfer of two-dimensional patterns of human umbilical vein Eendothelial cells into fibrin gels to facilitate vessel formation (2010)
  • Author(s): Kawashima T, Yokoi T, Kaji H, Nishizawa M
  • Journal Title: Chem. Commun Volume: 46 Pages: 2070-2072
  • Peer Reviewed
• [Journal Article] Evaluation of retinal degeneration in P27KIP1 Null Mice (2010)
  • Author(s): Tokita-Ishikawa Y, Wakusawa R, Abe T
  • Journal Title: Adv Exp Med Biol 664 Pages: 467-471
  • Peer Reviewed
• [Journal Article] Pureparation and characterization of collagen microspheres for sustained release of VEGF (2010)
  • Author(s): Nagai N, Kumasaka N, Kawashima T, Kaji H, Nishizawa M, Abe T
  • Journal Title: J Mater Sci Mater Med (Epub ahead of print)
  • Peer Reviewed
• [Journal Article] Vitreous Levels of Vasohibin-1 and Vascular Endothelial Growth Factor in Patients with Proliferative Diabetic Retinopathy (2009)
  • Author(s): Sato H, Abe T, Wakusawa R, Asai N, Kunikata H, Ohta Sonoda H, Sato Y, Nishida K
  • Journal Title: Diabetologia Volume: 52 Pages: 359-361
  • Peer Reviewed
• [Journal Article] TrkB-T1 Receptors on Muller Cells Play Critical Role in Brain-Derived Neurotrophic Factor-Mediated Photoreceptor Protection against Phototoxicity (2009)
  • Author(s): Saito T, Abe T, Wakusawa R, Sato H, Asai N, Tokita-Ishikaws Y, and Nishida K
  • Journal Title: CURRENT EYE RESEARCH Volume: 34(7) Pages: 580-588
  • Peer Reviewed
• [Journal Article] Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy (2009)
  • Author(s): Shimura M, Yasuda K, Nakazawa T, Abe T
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 247 Pages: 1617-1624
  • Peer Reviewed
• [Journal Article] Axisymmetric polydimethysiloxane microchannels for in vitro hemodynamic studies (2009)
  • Author(s): Lima R, Oliveira M, Ishikawa T, Kaji H, Tanaka S, Nishizawa M, Yamaguchi M
  • Journal Title: Biofabrication Volume: 1 Pages: 35005-35005
  • Peer Reviewed
• [Journal Article] Spatiotemporal subcellular biopatterning using an AFM-assisted electrochemical system (2009)
  • Author(s): Kaji H
  • Journal Title: Electrochem. Commun Volume: 11 Pages: 1781-1784
  • Peer Reviewed
• [Journal Article] Selective capture of a specific cell type from mixed leucocytes in an electrode-integrated microfluidic device (2009)
  • Author(s): Hashimoto M, Kaji H, Nishizawa M
  • Journal Title: Biosens. bioelectron Volume: 24 Pages: 2892-2897
  • Peer Reviewed
• [Journal Article] Controlled cocultures of HeLa cells and human umbilical vein endothelial cells on detachable substrates (2009)
  • Author(s): Kaji H
  • Journal Title: Lab Chip Volume: 9 Pages: 427-432
  • Peer Reviewed
• [Journal Article] Localized electrical stimulation to C2C12 myotubes cultured on a porous membrane-based substrate (2009)
  • Author(s): Ishibashi T, Hoshino Y, Kaji H, Kanzaki M, Sato M, Nishizawa M
  • Journal Title: Biomed. Microdevices Volume: 11 Pages: 413-419
  • Peer Reviewed
• [Journal Article] TrkB-T1 receptors on Muller cells play critical role in brain-derived nerve trophic factor-derived photoreceptor protection against phototoxicity (2009)
  • Author(s): Saito T, Abe T, Wakusawa R, Sato H, Asai H, Tokita-Ishikawa Y, Nishida K
  • Journal Title: Curr Eye Res 34 Pages: 580-588
  • Peer Reviewed
• [Journal Article] Panretinal photocoagulation induces pro-inflammatory cytokines and macular thickening in high-risk proliferative diabetic retinopathy (2009)
  • Author(s): Shimura M, Yasuda K, Nakazawa T, Abe T, Shiono T, Iida T, Sakamoto T, Nishida K
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 247 Pages: 1617-1624
  • Peer Reviewed
• [Presentation] PASCALを用いた網膜光凝固後の重篤な將液性網膜剥離 (2012)
  • Author(s): 岡村知世子、國方彦志、阿部俊明、針谷威寛、中澤徹
  • Organizer: 第35回日本眼科手術学会
  • Place of Presentation: 名古屋
• [Presentation] 東北大学病院における突発性傍中心窩毛細血管拡張症の特徴 (2011)
  • Author(s): 岡村知世子、國方彦志、新田文彦、阿部俊明
  • Organizer: 第50回日本網膜硝子体学会
  • Place of Presentation: 東京
• [Presentation] 網膜光障害モデルに対する経強膜DDSの網膜保護効果 (2011)
  • Author(s): 永井展裕、大浪英之、梶弘和、山田琢也、佐藤真智子、西澤松彦、阿部俊明
  • Organizer: 第33回日本バイオマテリアル学会
  • Place of Presentation: 京都
• [Presentation] 網膜保護用のマルチドラッグデリバリーシステム (2011)
  • Author(s): 永井展裕、大浪英之、梶弘和、山田琢也、佐藤真智子、西澤松彦、阿部俊明
  • Organizer: 第33回日本バイオマテリアル学会
  • Place of Presentation: 京都
• [Presentation] Transscleral sustained delivery by novel device (2011)
  • Author(s): Nobuhiro Nagai, Toshiaki Abe
  • Organizer: SDDS2011
  • Place of Presentation: Chenzhen, China
• [Presentation] 経強膜ドラッグデリバリーデバイスの開発 (2011)
  • Author(s): 阿部俊明、永井展裕、大浪英之、中澤徹、梶弘和、西澤松彦
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京
• [Presentation] 経強膜ドラッグデリバリーシステムによる網膜神経保護の試み (2011)
  • Author(s): 永井展裕、熊坂典浩、大浪英之、川島丈明、梶弘和、西澤松彦、阿部俊明
  • Organizer: 第27回日本DDS学会学術集会
  • Place of Presentation: 東京
• [Presentation] Evaluation of Ocular Tissue Distribution of Drugs Delivered Transsclerally From A Non-biodegradable Polymeric Capsule Device (2011)
  • Author(s): Nobuhiro Nagai, Takeaki Kawashima, Hirokazu Kaji, Hideyuki Onami, Norihiro Kumasaka, Matsuhiko Nishizawa, Toshiaki Abe
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale, USA
• [Presentation] Suppression of choroidal neovascularization by intravitreal vasohibin-1 in monkey eyes (2011)
  • Author(s): oshiaki Abe, Hideyuki Onami, Nobuhiro Nagai, Shigeki Machida, Norihiro Kumasaka, Ryosuke Wakusawa, Yumi Ishikawa, Hikaru Sonoda, Yasufumi Sato
  • Organizer: ARVO2011
  • Place of Presentation: Fort Lauderdale, USA
• [Presentation] 網膜変性疾患治療を目指したコラーゲン微粒子/ポリエチレングリコール複合体からなる薬剤徐放カプセルの作製と評価 (2011)
  • Author(s): 永井展裕、川島丈明、梶弘和、熊坂典浩、西澤松彦、阿部俊明
  • Organizer: 第10回日本再生医療学会総会
  • Place of Presentation: 東京
• [Presentation] A novel membrane-based drug delivery capsule for retinal neuroprotection (2010)
  • Author(s): Nobuhiro Nagai, Takeaki Kawashima, Norihiro Kumasaka, Hirokazu Kaji, Matsuhiko Nishizawa, Toshiaki Abe
  • Organizer: Pacifichem2010
  • Place of Presentation: Hawaii, USA
• [Presentation] 徐放制御性に優れたPEGカプセルの作成と網膜DDSへの応用 (2010)
  • Author(s): 熊坂典浩、永井展裕、川島丈明、梶弘和、大浪英之、西澤松彦、阿部俊明
  • Organizer: 第32回日本バイオマテリアル学会
  • Place of Presentation: 広島
• [Presentation] Vasohibin and retinal pigment epithelium (2010)
  • Author(s): Toshiaki Abe, Hideyuki Onami, Norihiro Kumasaka, Yumi Tokita-Ishikawa, Hikaru Sonoda, Tomoaki Takakura, Yasufumi Sato, Nobuhiro Nagai
  • Organizer: RD2010
  • Place of Presentation: Mont-Tremblant, canada
• [Presentation] コラーゲンとポリエチレングリコール複合体からなる薬物徐放制御に優れたカプセルDDSの作製 (2010)
  • Author(s): 永井展裕・川島丈明・梶弘和・熊坂典浩・西澤松彦・阿部俊明
  • Organizer: 第26回DDS学会
  • Place of Presentation: 大阪国際交流センター
• [Presentation] コラーゲン微粒子/ポリエチレングリコール複合体を用いた薬剤徐放カプセルの作製と評価 (2009)
  • Author(s): 川島丈明、永井展裕、梶弘和、西澤松彦、阿部俊明
  • Organizer: 第31回日本バイオマテリアル学会
  • Place of Presentation: 京都テルサ
• [Presentation] 糖尿病網膜症における非侵襲的皮膚AGE測定の有用性
  • Author(s): 安田正幸、金澤紘子、國方彦志、新田文彦、阿部俊明、宮田敏男、中澤徹
• [Presentation] 突発性黄斑円孔に対する硝子体手術成績とトリアムシノロンアセトニドの影響
  • Author(s): 金澤紘子、國方彦志、安田正幸、新田文彦、鬼怒川次郎、中澤徹、布施昇男、阿部俊明
• [Presentation] コラーゲン微粒子/ポリエチレグリコール複合体を用いた薬剤徐放カプセルの作製と評価
  • Author(s): 川島丈明、永井展裕、梶弘和、西澤松彦、阿部俊明
• [Book] 生理活性物質と眼疾患の基本、各種眼疾患と生理活性物質のかかわり、Behcet病 (2011)
  • Author(s): 阿部俊明
• [Remarks]
  • URL: http://www.dcct.med.tohoku.ac.jp/
• [Remarks]
  • URL: http://www.ctaar.med.tohoku.ac.jp/dcct/
• [Remarks]
  • URL: http://www.ctaar.med.tohoku.ac.jp/dcct/
• [Patent(Industrial Property Rights)] 持続性ドラックデリバリーシステム (2010)
  • Inventor(s): 阿部俊明、永井展裕、梶弘和、川島丈明、西澤松彦、西田幸二
  • Filing Date: 2010-08-10
  • Overseas
• [Patent(Industrial Property Rights)] 持続性ドラックデリバーシステム (2010)
  • Inventor(s): 阿部俊明、永井展裕、梶弘和、川島丈明、西澤松彦、西田幸二
  • Filing Date: 2010-08-10
  • Overseas
• [Patent(Industrial Property Rights)] 持続性ドラッグデリバリーシステム (2010)
  • Inventor(s): 阿部俊明、永井展裕、梶弘和、川島丈明、西澤松彦
  • Industrial Property Rights Holder: 東北大学
  • Filing Date: 2010-08-10
• [Patent(Industrial Property Rights)] 持続性ドラッグデリバリーシステム (2009)
  • Inventor(s): 阿部俊明、永井展裕、梶弘和、川島丈明、西澤松彦
  • Industrial Property Rights Holder: 東北大学
  • Industrial Property Number: 2009-189462
  • Filing Date: 2009-08-18