Role of D-amino acid-containing proteins in the development of diabetic retinopathy
| Project/Area Number |
21592216
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
KAJI Yuichi 筑波大学, 医学医療系, 准教授 (50361332)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 眼生化学 / 分子生物学 / D-アミノ酸 / AGE / タンパク糖化最終産物 / 角膜ジストロフィー / 糖尿病網膜症 / TGFBI / アミロイド / 光線力学療法 / ラセミ化 / D型アミノ酸 / 瞼裂斑 / climatic droplet keratopathy |
|---|
| Research Abstract |
First, we have shown that accumulation of D-amino acid-containing proteins in the basement membrane of the cornea induces diabetic keratopathy. Second, we have found increased concentration of D-amino acid-containing proteins in the vitreous fluid of diabetic retinopathy. Finally, we have developed a photodynamic therapy for corneal dystrophy using in vitro model.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] UV B-irradiation enhances the racemization and isomerizaiton of aspartyl residues and production of Ne-carboxymethyl lysine (CML) in keratin of skin2011
Author(s)
Mori Y, Aki K, Kuge K, Yamanaka N, Tajima S, Kaji Y, Nagai R, Yoshii H, Fujii N, Watanabe M, Kinouchi T, Fujii N
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Journal Title
Journal of Chromatography B
Volume: 879
Pages: 3303-3309
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Peer Reviewed
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[Presentation] 鏡の国の眼科学2010
Author(s)
加治優一
Organizer
第73回東京女子医科大学東医療センター眼科集談会
Place of Presentation
東京女子医科大学東医療センター
Year and Date
2010-03-06
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