Functional analysis of the cone photoreceptor cGMP-gated channel in rod monochromatism.
| Project/Area Number |
21592226
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
MURAKI Sanae 滋賀医科大学, 医学部, 講師 (90335175)
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| Co-Investigator(Kenkyū-buntansha) |
UEYAMA Hisao 滋賀医科大学, 医学部, 准教授 (30127013)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | CNGチャネル / 杆体一色覚 / CNGA3 / CNGB3 |
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| Research Abstract |
Defects of the ion channel in retinal cones are related to rod monochromatism(where functional cones are congenitally absent). When the 68 missense mutations(those causing a change in the amino acid sequence) of the channel so far reported were functionally studied, 16 gave membrane current but the others did not. Among the latter, some gave membrane current when the cells were cultured at lower temperature. With regard to such mutations, we are going to establish easier method to have the abnormal channel transported to the cell surface, for practical use.
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Report
(4 results)
Research Products
(17 results)
