The identification and prevention of the mechanism of photoreceptor cell death

• Project/Area Number: 21592229
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Osaka University
• Principal Investigator: TSUJIKAWA Motokazu 大阪大学, 医学系・研究科, 助教 (70419472)
• Co-Investigator(Kenkyū-buntansha): NAKAO Takeshi 大阪大学, 医学部附属病院, 医員 (00611170)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: ゼブラフィッシュ / 網膜色素変性 / フォトトランスダクション / 神経保護 / アデニルシ / スクリーニング / モデル動物 / 視細胞 / 可視化 / アポトーシス

Research Abstract

We revealed that zebrafish photoreceptor cell death model ovl shows photoreceptor cell death which relates phototransduction cascade. The cell death mechanism connects at transducine with phototransduction via adenylyl cyclase. Then we established RP zebrafish model which possesses human Q344X mutated rhodoposin. The mechanism of photoreceptor cell death was observed in this model and other mammalian RP model and will be a novel target of RP theraphy.

Research Products

• [Journal Article] The role of mislocalized phototransduction in photoreceptor cell death of retinitis pigmentosa (2012)
  • Author(s): Nakao T, Tsujikawa M, Notomi S, Ikeda Y, Nishida K
  • Journal Title: PLoS One Volume: 7
  • Peer Reviewed
• [Journal Article] The Role of Mislocalized Phototransduction in Photoreceptor Cell Death of Retinitis Pigmentosa (2012)
  • Author(s): Takeshi Nakao, Motokazu Tsujikawa, et al
  • Journal Title: PLOS ONE Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration (2012)
  • Author(s): Suzuki M, Tsujikawa M, Itabe H, Du ZJ, Xie P, Matsumura N, Fu X, Zhang R, Sonoda KH, Egashira K, Hazen SL, Kamei M
  • Journal Title: J Cell Sci Volume: Feb Pages: 2407-2415
  • DOI: 10.1242/jcs.097683
  • Peer Reviewed
• [Journal Article] Intravitreal bevacizumab for exudative branching vascular networks in polypoidal choroidal vasculopathy (2012)
  • Author(s): Wakabayashi T, Gomi F, Sawa M, Tsujikawa M, Nishida K
  • Journal Title: Br J Ophthalmol Volume: 96 Issue: 3 Pages: 394-9
  • DOI: 10.1136/bjo.2011.204123
  • Peer Reviewed
• [Journal Article] Effect of 1-year lutein supplementation on macular pigment optical density and visual function (2011)
  • Author(s): Sasamoto Y, Gomi F, Sawa M, Tsujikawa M, Nishida K
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 249 Pages: 1847-54
  • Peer Reviewed
• [Journal Article] Intravitreal bevacizumab for exudative branching vascular networks in polypoidal choroidal vasculopathy (2011)
  • Author(s): Wakabayashi T, Gomi F, Sawa M, Tsujikawa M, Nishida K
  • Journal Title: Br J Ophthalmol Volume: (in press)
  • Peer Reviewed
• [Journal Article] Simultaneous intravitreal injection of triamcinolone acetonide and tissue plasminogen activator for central retinal vein occlusion : a pilot study (2011)
  • Author(s): Yamamoto T, Kamei M, Sayanagi K, Matsumura N, Nishida K, Sakaguchi H, Tsujikawa M, Tano Y
  • Journal Title: Br J Ophthalmol Volume: 95 Pages: 69-73
  • Peer Reviewed
• [Journal Article] Effect of Cataract in Evaluation of Macular Pigment Optical Density Using Autofluorescence Spectrometry (2011)
  • Author(s): Sasamoto Y, Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Nishida K
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Pages: 927-32
  • Peer Reviewed
• [Journal Article] Effect of cataract in evaluation of macular pigment optical density by a utofluorescence spectrometry (2011)
  • Author(s): Sasamoto Y, Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Nishida K
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 56 Issue: 2 Pages: 927-32
  • DOI: 10.1167/iovs.10-5664
  • Peer Reviewed
• [Journal Article] Simultaneous intravitreal injection of triamcinolone acetonide and tissue plasminogen activator for central retinal vein occlusion : a pilot study (2011)
  • Author(s): Yamamoto T, Kamei M, Sayanagi K, Matsumura N, Nishida K, Sakaguchi H, Tsujikawa M, Tano Y
  • Journal Title: Br J Ophthalmol. Volume: 95 Pages: 69-73
  • Peer Reviewed
• [Journal Article] Chromosomal sharing in atypical cases of gelatinous drop-like corneal dystrophy (2010)
  • Author(s): Tsujikawa M, Maeda N, Tsujikawa K, Hori H, Inoue T, Nishida K
  • Journal Title: Jpn J Ophthalmol Volume: 54 Pages: 494-8
  • NAID: 10027666035
  • Peer Reviewed
• [Journal Article] Tumor-Associated Calcium Signal Transducer 2 Is Required for the Proper Subcellular Localization of Claudin 1 and 7. Implications in the Pathogenesis of Gelatinous Drop-Like Corneal Dystrophy (2010)
  • Author(s): Nakatsukasa M, Kawasaki S, Yamasaki K, Fukuoka H, Matsuda A, Tsujikawa M, Tanioka H, Nagata-Takaoka M, Hamuro J, Kinoshita S
  • Journal Title: Am J Pathol Volume: 177 Pages: 1344-55
  • Peer Reviewed
• [Journal Article] Efficacy of intravitreal bevacizumab combined with photodynamic therapy for polypoidal choroidal vasculopathy (2010)
  • Author(s): Gomi F, Sawa M, Wakabayashi T, Sasamoto Y, Suzuki M, Tsujikawa M
  • Journal Title: Am J Ophthalmol Volume: 150 Pages: 48-54
  • Peer Reviewed
• [Journal Article] Correlation of fundus autofluorescence with photoreceptor morphology and functional changes in eyes with retinitis pigmentosa (2010)
  • Author(s): Wakabayashi T, Sawa M, Gomi F, Tsujikawa M
  • Journal Title: Acta Ophthalmol Volume: 88 Pages: 177-83
  • Peer Reviewed
• [Journal Article] Macular Pigment Optical Density in Central Serous Chorioretinopathy (2010)
  • Author(s): Sasamoto Y, Gomi F, Sawa M, Tsujikawa M, Hamasaki T
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 51 Pages: 2519-25
  • Peer Reviewed
• [Journal Article] Bevacizumab treatment for choroidal neovascularization due to age-related macular degeneration in Japanese patients (2010)
  • Author(s): Suzuki M, Gomi F, Sawa M, Tsujikawa M, Sakaguchi H
  • Journal Title: Jpn J Ophthalmol Volume: 54 Pages: 124-8
  • NAID: 10027203715
  • Peer Reviewed
• [Journal Article] Association between the efficacy of photodynamic therapy and indocyanine green angiography findings for central serous chorioretinopathy (2010)
  • Author(s): Inoue R, Sawa M, Tsujikawa M, Gomi F
  • Journal Title: Am J Ophthalmol Volume: 149 Pages: 441-6
  • Peer Reviewed
• [Journal Article] Tumor-Associated Calcium Signal Transducer 2 Is Required for the Proper Subcellular Localization of Claudin 1 and 7. (2010)
  • Author(s): Nakatsukasa M, Kawasaki S, Yamasaki K, Fukuoka H, Matsuda A, Tsujikawa M, et.al
  • Journal Title: Am.J.Pathology Volume: 177 Pages: 1344-55
  • Peer Reviewed
• [Journal Article] Effect of Cataract in Evaluation of Macular Pigment Optical Density Using Autofluorescence Spectrometry. (2010)
  • Author(s): Sasamoto Y, Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Nishida K.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Pages: 927-932
  • Peer Reviewed
• [Journal Article] Chromosomal sharing in atypical cases of gelatinous drop-like corneal dystrophy. (2010)
  • Author(s): Tsujikawa M, Maeda N, Tsujikawa K, Hori H, Inoue T, Nishida K.
  • Journal Title: Jpn J Ophthalmol Volume: 54 Pages: 494-498
  • NAID: 10027666035
  • Peer Reviewed
• [Journal Article] Bevacizumab treatment for choroidal neovascularization due to age-related macular degeneration in Japanese patients. (2010)
  • Author(s): Suzuki M, Gomi F, Sawa M, Tsujikawa M, Sakaguchi H
  • Journal Title: Jpn J Ophthalmol Volume: 54 Pages: 124-128
  • NAID: 10027203715
  • Peer Reviewed
• [Journal Article] Association between the efficacy of photodynamic therapy and indocyanine green angiography findings for central serous chorioretinopathy (2010)
  • Author(s): Inoue R, Sawa M, Tsujikawa M, Gomi F.
  • Journal Title: Am J Ophthalmol Volume: 149 Pages: 441-446
  • Peer Reviewed
• [Journal Article] Association between the efficacy of photodynamic therapy and indocyanine green angiography findings for central serous chorioretinopathy (2010)
  • Author(s): Inoue R, Sawa M, Tsujikawa M, Gomi F.
  • Journal Title: Am J Ophthalmol 149 Pages: 441-6
  • Peer Reviewed
• [Journal Article] Sayanagi K, Ikuno Y, Soga K, Wakabayashi T, Tsujikawa M, Tano Y (2009)
  • Author(s): Sayanagi K, Ikuno Y, Soga K, Wakabayashi T, Tsujikawa M, Tano Y
  • Journal Title: Br J Ophthalmol Volume: 93 Pages: 1687-90
  • Peer Reviewed
• [Journal Article] Long-term results of intravitreal bevacizumab injection for choroidal neovascularization secondary to angioid streaks (2009)
  • Author(s): Sawa M, Gomi F, Tsujikawa M, Sakaguchi H, Tano Y
  • Journal Title: Am J Ophthalmol Volume: 148 Pages: 584-590
  • Peer Reviewed
• [Journal Article] One-year results of combined photodynamic therapy and intravitreal bevacizumab injection for retinal pigment epithelial detachment secondary to age-related macular degeneration (2009)
  • Author(s): Shima C, Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Tano Y
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 247 Pages: 899-906
  • Peer Reviewed
• [Journal Article] Macular autofluorescence in eyes with cystoid macula edema, detected with 488 nm-excitation but not with 580 nm-excitation (2009)
  • Author(s): Bessho K, Gomi F, Harino S, Sawa M, Sayanagi K, Tsujikawa M, Tano Y
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 247 Pages: 729-34
  • Peer Reviewed
• [Journal Article] Intravitreal Bevacizumab for Choroidal Neovascularization Attributable to Pathological Myopia : One-Year Results (2009)
  • Author(s): Ikuno S, Sayanagi K, Soga K, Sawa M, Tsujikawa M, Gomi F, Tano Y
  • Journal Title: Am J Ophthalmol Volume: 147 Pages: 94-100
  • Peer Reviewed
• [Journal Article] Macular autofluorescence in eyes with cystoid macula edema, detected with 488 nm-excitation but not with 580 nm-excitation (2009)
  • Author(s): Bessho K, Gomi F, Harino S, Sawa M, Sayanagi K, Tsujikawa M, Tano Y
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 247 Pages: 729-34
  • Peer Reviewed
• [Journal Article] One-year results of combined photodynamic therapy and intravitreal bevacizumab injection for retinal pigment epithelial detachment secondary to age-related macular degeneration (2009)
  • Author(s): Shima C, Gomi F, Sawa M, Sakaguchi H, Tsujikawa M, Tano Y
  • Journal Title: Graefes Arch Clin Exp Ophthalmol 247 Pages: 899-906
  • Peer Reviewed
• [Journal Article] Long-term results of intravitreal bevacizumab injection for choroidal neovascularization secondary to angioid streaks (2009)
  • Author(s): Sawa M, Gomi F, Tsujikawa M, Sakaguchi H, Tano Y
  • Journal Title: Am J Ophthalmol 148 Pages: 584-590
  • Peer Reviewed
• [Journal Article] Choroidal vascular hypofluorescence in indocyanine green angiography of high myopia (2009)
  • Author(s): Sayanagi K, Ikuno Y, Soga K, Wakabayashi T, Tsujikawa M, Tano Y
  • Journal Title: Br J Ophthalmol 93 Pages: 1687-90
  • Peer Reviewed
• [Presentation] Phase I traial of Anti-VEGFR Vaccine Therapy for Neovascular Maculopathy (2011)
  • Author(s): Tsujikawa M
  • Organizer: Hong-Kong International Ophthalmology Symposium
  • Place of Presentation: Hong Kong、中国(招待講演)
  • Year and Date: 2011-12-04
• [Presentation] Phase I traial of Anti-VEGFR Vaccine Therapy for Neovascular Maculopathy (2011)
  • Author(s): Tsujikawa M, Miki Sawa, Yasushi Ikuno, Fumi Gomi, Kohji Nishida, Koji Yoshida, Tatsuya Tsunoda, Yusuke Nakamura
  • Organizer: American Academy of Ophthalmology annual meeting
  • Place of Presentation: Florida,アメリカ
  • Year and Date: 2011-11-21
• [Presentation] 加齢黄斑変性に対するHLA^*A拘束性抗VEGFEワクチン療法 (2011)
  • Author(s): 辻川元一、沢美喜、五味文、大路正人、白神史雄、高橋寛二、西田幸二
  • Organizer: 第65回日本臨床眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2011-10-07
• [Presentation] 小胞体ストレスモニター動物の開発 (2011)
  • Author(s): 辻川元一、中尾武史、西田幸二
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] 網膜色素変性モデルゼブラフィッシュにおける視細胞死の検討 (2011)
  • Author(s): 中尾武史、辻川元一、佐々本弦、西田幸二
  • Organizer: 第115回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-05-13
• [Presentation] Light dependent photoreceptor cell death in retinitis pigmetosa model fish APAO Sydney (2011)
  • Author(s): Tsujikawa M
  • Organizer: オーストラリア
  • Place of Presentation: オーストラリア
  • Year and Date: 2011-03-22
• [Presentation] 落屑症候群における角膜内皮細胞数の変化 (2011)
  • Author(s): 後藤聡、相馬剛至、辻川元一、松下賢治、三木篤也、高静花、前田直之、西田幸二
  • Organizer: 第35回日本角膜学会
  • Place of Presentation: 東京
  • Year and Date: 2011-02-17
• [Presentation] ドライアイに対する涙点プラグの長期的効果 (2011)
  • Author(s): 高静花、相馬剛至、渡辺仁、堀裕一、辻川元一、前田直之、西田幸二
  • Organizer: 第35回日本角膜学会
  • Place of Presentation: 東京
  • Year and Date: 2011-02-17
• [Presentation] TACSTD2遺伝子の系統発生学上の特徴 (2011)
  • Author(s): 辻川元一、西田幸二
  • Organizer: 第35回日本角膜学会
  • Place of Presentation: 東京
  • Year and Date: 2011-02-17
• [Presentation] 膠様滴状角膜ジストロフィの系統発生学上の特徴 (2011)
  • Author(s): 辻川元一、西田幸二
  • Organizer: 角膜カンファランス2011
  • Place of Presentation: 品川プリンスホテル(東京)
  • Year and Date: 2011-02-17
• [Presentation] ベバシズマブからラビニズマブへ治療移行した加齢黄斑変性奨励の網膜厚測定 (2010)
  • Author(s): 上野千佳子、五味文、沢美喜、辻川元一、西田幸二
  • Organizer: 第49回日本網膜硝子体学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2010-11-26
• [Presentation] 短焦点高速型波面センサーを用いた点眼後眼球高次収差の測定 (2010)
  • Author(s): 渕端睦、高静花、東浦律子、戸田良太郎、相馬剛至、辻川元一、前田直之、不二門尚、西田幸二
  • Organizer: 第64回日本臨床眼科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-13
• [Presentation] フィブリン滲出を伴う中心性漿液性脈絡網膜症に対する光線力学的療法 (2010)
  • Author(s): 黒田聡、五味文、沢美喜、辻川元一、西田幸二
  • Organizer: 第64回日本臨床眼科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-11
• [Presentation] ルテイン内服による正常眼の視機能への効果 (2010)
  • Author(s): 五味文、沢美喜、辻川元一、西田幸二
  • Organizer: 第64回日本臨床眼科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-11
• [Presentation] ドライアイにおける、前眼部OCTによる涙液メニスカスの観察 (2010)
  • Author(s): 高静花、渕端睦、東浦律子、相馬剛至、戸田良太郎、辻川元一、前田直之、西田幸二
  • Organizer: 第64回日本臨床眼科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-11
• [Presentation] 異なる治療間隔で施行したベバシズマブ併用光線力学療法の比較検討 (2010)
  • Author(s): 沢美喜、岩田英嗣、石川浩平、辻川元一、五味文、寺崎浩子、西田幸二、濱崎俊光
  • Organizer: 第64回日本臨床眼科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-11
• [Presentation] 滲出型加齢黄斑変性に対するベバシズマブ投与の2年経過 (2010)
  • Author(s): 鈴木三保子、五味文、沢美喜、辻川元一、西田幸二
  • Organizer: 第64回日本臨床眼科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-11
• [Presentation] 加齢黄斑変性に対するHLA* A拘束性抗VEGFRワクチン治療の第I相臨床試験 (2010)
  • Author(s): 辻川元一、沢美喜、五味文、白神史雄、高橋寛二、大路正人、西田幸二
  • Organizer: 第64回日本臨床眼科学会総会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-11
• [Presentation] 加齢黄斑変性に対するHLA* A拘束性抗VEGFRワクチン療法の第I相試験 (2010)
  • Author(s): 辻川元一、沢美喜、五味文、白神史雄、高橋寛二、大路正人、西田幸二
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-11-11
• [Presentation] Choroidal Findings of Central Serous Chorioretinopathy Using High-penetratio OCT with a 1-Micron Band (2010)
  • Author(s): Kuroda S, Ikuno Y, Yasuno Y, Sawa M, Tsujikawa M, Nishida K
  • Organizer: 2010 American Academy of Ophthalmology
  • Place of Presentation: Chicago,アメリカ
  • Year and Date: 2010-10-16
• [Presentation] Effect of 1. 25% Povidone-Iodine Combined with Topical Levofloxacin on Conjunctival Flora in Patients Undergoing Intravitreal Injection (2010)
  • Author(s): Ikuno Y, Sawa M, Tsujikawa M, Gomi F, Maeda N
  • Organizer: 2010 American Academy of Ophthalmology
  • Place of Presentation: Chicago,アメリカ
  • Year and Date: 2010-10-16
• [Presentation] 加齢黄斑変性に対するHLA*A拘束性抗VEGFRワクチン療法の第I相試験 (2010)
  • Author(s): 辻川元一、沢美喜、五味文、生野恭司, 他
  • Organizer: 第63回日本臨床眼科学会
  • Place of Presentation: 福岡国際会議場 (福岡)
  • Year and Date: 2010-10-11
• [Presentation] Experimental Models of Retinitis Pigmentosa in Zebrafish Symposium Advances in the molecular biology of macular diseases (2010)
  • Author(s): Tsujikawa M
  • Organizer: APAO 2010
  • Place of Presentation: Beijing,中国
  • Year and Date: 2010-09-18
• [Presentation] Generation of Transgenic Zebrafish Lines With Human Rhodopsin Mutations (2010)
  • Author(s): Motokazu Tsujikawa, Takeshi Nakao
  • Organizer: APAO 2010
  • Place of Presentation: 北京北斗国際会議場 (中国)(招待講演)
  • Year and Date: 2010-09-18
• [Presentation] Correlation of macular pigment distribution in type 2 idiopathic macular telangiectasia and morphologic abnormalities detected by spectral-domain (2010)
  • Author(s): Sawa M, Sasamoto Y, Tsujikawa M, Gomi F
  • Organizer: OCT
  • Place of Presentation: WOC Berlin(ドイツ)
  • Year and Date: 2010-06-07
• [Presentation] Photoreceptor Cell Death in a Zebrafish Model of Autosomal Dominant (2010)
  • Author(s): Nakao T, Tsujikawa M
  • Organizer: Retinitis Pigmentosa 2010
  • Place of Presentation: WOC Berlin(ドイツ)
  • Year and Date: 2010-06-07
• [Presentation] Generation of transgenic zebrafish lines with human rhodopsin mutations (2010)
  • Author(s): Tsujikawa M, Sasamoto Y, Matsumura B, Nakao T
  • Organizer: Best Poster Award
  • Place of Presentation: WOC Berlin(ドイツ)
  • Year and Date: 2010-06-07
• [Presentation] Comparison of intravitreal bevacizumab alone versus combined with photodynamic therapy for small CNV lesions of age-related macular degeneration 2010 (2010)
  • Author(s): Suzuki M, Gomi F, Sawa M, Tsujikawa M
  • Place of Presentation: WOC Berlin(ドイツ)
  • Year and Date: 2010-06-07
• [Presentation] High-speed, high-penetration, swept-source optical coherence tomography at 1 micrometer wavelength band for posterior eye diseases (2010)
  • Author(s): Ikuno Y, Yasuno Y, Sawa M, Tsujikawa M, Gomi F
  • Place of Presentation: WOC Berlin(ドイツ)
  • Year and Date: 2010-06-07
• [Presentation] Photoreceptor Cell Death in a Zebrafish Model of Autosomal Dominant Retinitis Pigmentosa (2010)
  • Author(s): Nakao T, Tsujikawa M
  • Organizer: WOC 2010
  • Place of Presentation: ベルリン国際会議場(ドイツ)
  • Year and Date: 2010-06-05
• [Presentation] Generation of Transgenic Zebrafish Lines With Human Rhodopsin Mutations (2010)
  • Author(s): Motokazu Tsujikawa, Yuzuru Sasamoto, Nagakazu Matsumura, Takeshi Nakao
  • Organizer: WOC 2010
  • Place of Presentation: ベルリン国際会議場(ドイツ)
  • Year and Date: 2010-06-05
• [Presentation] Generation of Transgenic Zebrafish Lines With Human Rhodopsin Mutations (2010)
  • Author(s): Sasamoto Y, Nakao T, Matsumura N, Tsujikawa M
  • Organizer: ARVO
  • Place of Presentation: アメリカ
  • Year and Date: 2010-05-03
• [Presentation] Choroidal Thickness Measurement in Central Serous Chorioretinopathy Using High-Penetration Optical Coherence Tomography (2010)
  • Author(s): Kuroda S, Ikuno Y, Sawa M, Tsujikawa M, Gomi F, Yasuno Y
  • Organizer: ARVO
  • Place of Presentation: アメリカ
  • Year and Date: 2010-05-03
• [Presentation] Tacstd2 Protein Directly Binds to Claudin Proteins and is Required for the Proper Subcellular Localization of Tight Junction-Related Proteins ; Roles of Tacstd2 Protein in the Pathogenesis of Gelatinous Drop-Like Dystrophy (2010)
  • Author(s): Kawasaki S, Nakatsukasa M, Yamasaki K, Tsujikawa M et al
  • Organizer: ARVO
  • Place of Presentation: アメリカ
  • Year and Date: 2010-05-03
• [Presentation] The Involvement of Oxidized Phospholipids in Choroidal Neovascularization (2010)
  • Author(s): Suzuki M, Tsujikawa M, Itabe H, Sonoda K-H, Egashira K, Kamei M
  • Organizer: ARVO
  • Place of Presentation: アメリカ
  • Year and Date: 2010-05-03
• [Presentation] Lipopolysaccharide Pretreatment Suppresses Choroidal Neovascularization (2010)
  • Author(s): Matsumura N, Tsujikawa M, Xie P, et al
  • Organizer: ARVO
  • Place of Presentation: アメリカ
  • Year and Date: 2010-05-03
• [Presentation] Phototransduction and Photoreceptor Cell Death Are Closely Related in a Zebrafish Model of Autosomal Dominant Retinitis Pigmentosa (2010)
  • Author(s): Nakao T, Tsujikawa M.
  • Organizer: ARVO
  • Place of Presentation: アメリカ
  • Year and Date: 2010-05-03
• [Presentation] 眼底自発蛍光を応用した黄斑色素測定における白内障の影響 (2010)
  • Author(s): 佐々本弦、五味文、坂口裕和、松下賢治、橋田徳康、辻川元一
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-17
• [Presentation] Heterochromatic Flicker Photometry法による黄斑色素測定 (2010)
  • Author(s): 沢美喜、佐々本弦、辻川元一、五味文
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-17
• [Presentation] TACSTD2の対とジャンクションにおける機能的意義 (2010)
  • Author(s): 中司美奈、川崎諭、山崎健太、福岡秀記、松田彰、辻川元一、谷岡秀敏、永田真帆、羽室淳爾、木下茂
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-16
• [Presentation] 黄斑浮腫を伴う網膜静脈分子閉塞賞の浮腫形態別の予後 (2010)
  • Author(s): 上田朋子、五味文、鈴木三保子、沢美喜、坂口裕和、大島祐輔、生野恭司、辻川元一、瓶井資弘、日下俊次
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-15
• [Presentation] 抗VEGF両方の1年間の試行回数に影響を与えるspectral-domain OCT所見 (2010)
  • Author(s): 佐柳香織、五味文、沢美喜、坂口裕和、辻川元一
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-15
• [Presentation] 高侵達光干渉断層計を用いた中心性漿液性網脈絡膜症の脈絡膜厚計測 (2010)
  • Author(s): 黒田聡、生野恭司、沢美喜、辻川元一、五味文、安野嘉晃
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-15
• [Presentation] ゼブラフィッシュ変異体ovlにおける視細胞死を引き起こすメカニズム (2010)
  • Author(s): 中尾武史、辻川元一、松村永和、佐々本弦
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-15
• [Presentation] ヒトロドプシン変異を導入したトランスジェニック魚の作出 (2010)
  • Author(s): 辻川元一、中尾武史、松村永和、佐々本弦、田野保雄
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-15
• [Presentation] ちゃんとできるDNAクローニングシンポジウム (2010)
  • Author(s): 辻川元一
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-15
• [Presentation] ヒトロドプシン変異を導入したトランスジェニック魚の作出 (2010)
  • Author(s): 辻川元一、中尾武史、松村永和、佐々本弦、田野保雄
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場 (名古屋)
  • Year and Date: 2010-04-15
• [Presentation] Phototransduction and Photoreceptor Cell Death Are Closely Related in a Zebrafish Model of Autosomal Dominant Retinitis Pigmentosa (2010)
  • Author(s): Nakao T, Tsujikawa M
  • Organizer: ARVO 2010
  • Place of Presentation: フォートローダデール国際会議場(フロリダ・アメリカ)
  • Year and Date: 2010-04-11
• [Presentation] Generation of Transgenic Zebrafish Lines With Human Rhodopsin Mutations (2010)
  • Author(s): Sasamoto Y, Nakao T, Matsumura N, Tsujikawa M
  • Organizer: ARVO 2010
  • Place of Presentation: フォートローダデール国際会議場(フロリダ・アメリカ)
  • Year and Date: 2010-04-11
• [Presentation] 加齢黄斑変性に対するHLA*A拘束性VEGFRワクチン療法の第I相試験 (2009)
  • Author(s): 辻川元一、沢美喜、五味文, 他
  • Organizer: 第63回日本臨床眼科学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-11
• [Presentation] 小胞体ストレス可視化モデルフィッシュ (2009)
  • Author(s): 辻川元一
  • Organizer: 第63回日本臨床眼科学会
  • Place of Presentation: 福岡
  • Year and Date: 2009-10-11
• [Presentation] 実質混濁をきたす角膜ジストロフィの診断 (2009)
  • Author(s): 辻川元一
  • Organizer: 第113回日本眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-17
• [Presentation] 網膜色素変性モデルゼブラフィッシュにおける視細胞死の検討 (2009)
  • Author(s): 中尾武史、松村永和、辻川元一、田野保雄
  • Organizer: 第113回日本眼科学会
  • Place of Presentation: 東京
  • Year and Date: 2009-04-16
• [Book] 加齢黄斑変性 (2009)
  • Author(s): 大路正人、五味文、辻川元一, 他
  • Total Pages: 79
  • Publisher: 医薬ジャーナル社
• [Book] 加齢黄斑変性 (2009)
  • Author(s): 大路正人、五味文, 他
  • Total Pages: 79
  • Publisher: 医薬ジャーナル社