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Vascular maturation and its association with hematopoietic stem dells in intraocular neovascularization

Research Project

Project/Area Number 21592230
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionOsaka University

Principal Investigator

OSHIMA Yusuke  大阪大学, 医学系・研究科, 講師 (20362717)

Co-Investigator(Kenkyū-buntansha) GOMI Fumi  大阪大学, 医学系・研究科, 講師 (80335364)
IKUNO Yasushi  大阪大学, 医学系・研究科, 講師 (50294096)
KAMEI Motohiro  大阪大学, 医学系・研究科, 准教授 (40281125)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords血管内皮増殖因子 / 造血系幹細胞 / テノモジュリン / 眼内血管新生 / 増殖糖尿病網膜症 / 血管新生緑内障 / 未熟児網膜症 / VEGF / SDF1α / 造血幹細胞 / 血管前駆細胞 / 抗VEGF抗体 / 抗SDF1α抗体 / 血管線維増殖膜 / SDF1□ / 血管血管 / 新生血管増殖膜
Research Abstract

In addition to the previously reported vascular endothelial growth factor, Stromal cell-derived factor 1α(SDF-1α) and its inducing endothelial progenitor cells can play important roles in neovascularization and vascular maturation in a variety of intraocular neovascular diseases such as proliferative diabetic retinopathy and neovascular glaucoma. The tendon-derived anti-angiogenic factor, tenomodulin, can suppress the intraocular neovascular activities via the interaction with these factors.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (26 results)

All 2012 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (13 results) Book (2 results)

  • [Journal Article] Clinical outcomes and changes in aqueous vascular endothelial growth factor levels after intravitreal bevacizumab for iris neovascularization and neovascular glaucoma : a retrospective two-dose comparative study2012

    • Author(s)
      Sasamoto Y, Oshima Y, Miki A, Wakabayashi T, Song D, Matsushita K, Hamasaki T, Nishida K
    • Journal Title

      J Ocul Pharmacol Ther

      Volume: 28(1) Pages: 41-8

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clinical Outcomes and Changes in Aqueous Vascular Endothelial Growth Factor Levelsafter Intravitreal Bevacizumab for Iris Neovascularization and Neovascular Glaucoma : A Retrospective Two-Dose Comparative Study2011

    • Author(s)
      Sasamoto Y, Oshima Y, et al
    • Journal Title

      Journal of Ocular Pharmacology and Therapeutics

      Volume: (印刷中)(未定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-year results of intravitreal bevacizumab as an adjunct to trabeculectomy for neovascular glaucoma in eyes with previous vitrectomy2011

    • Author(s)
      Miki A, Oshima Y, et al
    • Journal Title

      Eye

      Volume: 25 Issue: 5 Pages: 258-259

    • DOI

      10.1038/eye.2011.58

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 27-gauge sharp-tip short-shaft pneumatic vitreous cutter for transconjunctival sutureless vitreous biopsy2011

    • Author(s)
      Oshima Y, Et al
    • Journal Title

      Retina

      Volume: 31 Issue: 2 Pages: 419-421

    • DOI

      10.1097/iae.0b013e3182083df8

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A 27-gauge instrument system for transconjunctival sutureless micro-incision vitrectomy surgery2010

    • Author(s)
      Oshima Y, et al.
    • Journal Title

      Ophthalmology

      Volume: 117 Pages: 93-102

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bacterial contamination of the vitreous cavity associated with transconjunctival 25-gauge microincision vitrectomy surgery2010

    • Author(s)
      Tominaga A, Oshima Y, et al.
    • Journal Title

      Ophthalmology

      Volume: 117 Pages: 811-817

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foveal microstructure and visual acuity in surgically closed macular holes : spectral-domain optical coherence tomographic analysis2010

    • Author(s)
      Wakabayashi T, Oshima Y, et al
    • Journal Title

      Ophthalmology

      Volume: 117 Pages: 1815-1824

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Microincision vitrectomy surgery and intravitreal bevacizumab as a surgical adjunct to treat diabetic traction retinal detachment2009

    • Author(s)
      Oshima Y, Shima C, Wakabayashi T, Kusaka S, Shiraga F, Ohji M, Tano Y
    • Journal Title

      Ophthalmology

      Volume: 116(5) Pages: 927-38

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Microincision vitrectomy surgery and intravitreal bevacizumab as a surgical adjunct to treat diabetic traction retinal detachment2009

    • Author(s)
      Oshima Y, et al.
    • Journal Title

      Ophthalmology 116

      Pages: 927-938

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foveal microstructure and visual acuity after retinal detachment repair : Imaging analysis by fourier-domain optical coherence tomography2009

    • Author(s)
      Wakabayashi T, Oshima Y, et al
    • Journal Title

      Ophthalmology 116

      Pages: 519-528

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Retinal vascular traction-induced recurrence of retinal detachment in patients with myopic macular hole2009

    • Author(s)
      Sayanagi K, Oshima Y, et al.
    • Journal Title

      Ophthalmic Surgery, Laser and Imaging 40

      Pages: 60-64

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] Advanced vitreoretinal surgical techniques and pharmacotherapy : pros and cons of anti-VEGF adjuncts for diabetic vitrectomy2012

    • Author(s)
      Oshima Y.
    • Organizer
      World Ophthalmology Congress 2012
    • Place of Presentation
      Abu Dahbi, UAE
    • Year and Date
      2012-02-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 増殖糖尿病網膜症の難知性合併症に対する手術と薬物治療のクロストーク2011

    • Author(s)
      大島佑介
    • Organizer
      第22回大阪市眼科研究会
    • Place of Presentation
      大阪(招待講演)
    • Year and Date
      2011-07-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Micro incision vitrectomy surgery and intravitreal bevacizumab as a surgical adjunct to treat diabetic traction retinal detachment : pros and cons2011

    • Author(s)
      Oshima Y.
    • Organizer
      The 1^<st> Leuven Retina Meeting
    • Place of Presentation
      Leuven, Bergium(招待講演)
    • Year and Date
      2011-07-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] 重症増殖糖尿病網膜症の治療戦略: bevacizumabの功罪2010

    • Author(s)
      大島佑介
    • Organizer
      東京医科歯科大学眼科フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2010-01-31
    • Related Report
      2011 Final Research Report
  • [Presentation] Vitreoretinal surgery and pharmacotherapy for diabetic retinopathy and macular edema2010

    • Author(s)
      Oshima Y
    • Organizer
      The 25^<th> Congress of Asia-Pacific Academy of Ophthalmology, AOI-Symposium
    • Place of Presentation
      Beijing, China
    • Related Report
      2011 Final Research Report
  • [Presentation] Aqueous humor levels of vascular endothelial growth factor before and after intravitreal bevacizumab in eyes with neovascular glaucoma2010

    • Author(s)
      Sasamoto Y, Oshima Y
    • Organizer
      World Ophthalmology Congress 2010
    • Place of Presentation
      Berlin, Germany
    • Related Report
      2011 Final Research Report
  • [Presentation] Intravitreal bevacizumab to treat iris neovascularization and neovascular glaucoma secondary to ischemic retinal diseases2010

    • Author(s)
      Oshima Y
    • Organizer
      The 3^<rd> Cairo Retina Meeting
    • Place of Presentation
      エジプト・カイロ(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Vitreoretinal surgery and pharmacotherapy for diabetic retinopathy and macular edema2010

    • Author(s)
      Oshima Y
    • Organizer
      The 25^<th> Congress of Asia-Pacific Academy of Ophthalmology, AOI-Symposium
    • Place of Presentation
      中国・北京(招待講演)
    • Related Report
      2010 Annual Research Report
  • [Presentation] Aqueous humor levels of vascular endothelial growth factor before and after intravitreal bevacizumab in eyes with neovascular glaucoma2010

    • Author(s)
      Sasamoto Y, Oshima Y, et al
    • Organizer
      World Ophthalmology Congress 2010
    • Place of Presentation
      ドイツ・ベルリン
    • Related Report
      2010 Annual Research Report
  • [Presentation] 増殖糖尿病網膜症に対する治療戦略:bevacizumabの功罪2009

    • Author(s)
      大島佑介
    • Organizer
      東北大学・宮城眼科先進医療研究会
    • Place of Presentation
      仙台
    • Year and Date
      2009-07-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 血管新生緑内障に対するbevacizumab硝子体内投与前後の前房内VEGF濃度変化2009

    • Author(s)
      佐々本弦、大島佑介
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-17
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Vitreoretinal surgery and pharmacotherapy for diabetic retinopathy and macular edema2009

    • Author(s)
      Oshima Y
    • Organizer
      Academia Ophthalmologica Internationalis Symposium, American Academy of Ophthalmology Annual Meeting
    • Place of Presentation
      San Francisco, USA
    • Related Report
      2011 Final Research Report 2009 Annual Research Report
  • [Presentation] Microincision vitrectomy surgery and intravitreal bevacizumab as a surgical adjunct to treat diabetic traction retinal detachment2009

    • Author(s)
      大島佑介
    • Organizer
      The 24^<th> Congress of Asia-Pacific Academy of Ophthalmology, Symposium
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2009 Annual Research Report
  • [Book] Principales and instrumentations. Vitreo-retinal Surgery Progress III. Series : Essentials in Ophthalmology2009

    • Author(s)
      Oshima Y, TanoY
    • Publisher
      Springer Inc
    • Related Report
      2011 Final Research Report
  • [Book] Principales and instrumentations. Vitreo-retinal Surgery Progress III. Series : Essentials in Ophthalmology2009

    • Author(s)
      Oshima Y, Tano Y
    • Total Pages
      850
    • Publisher
      Springer Inc.
    • Related Report
      2009 Annual Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

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