Vascular maturation and its association with hematopoietic stem dells in intraocular neovascularization
| Project/Area Number |
21592230
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
OSHIMA Yusuke 大阪大学, 医学系・研究科, 講師 (20362717)
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| Co-Investigator(Kenkyū-buntansha) |
GOMI Fumi 大阪大学, 医学系・研究科, 講師 (80335364)
IKUNO Yasushi 大阪大学, 医学系・研究科, 講師 (50294096)
KAMEI Motohiro 大阪大学, 医学系・研究科, 准教授 (40281125)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 血管内皮増殖因子 / 造血系幹細胞 / テノモジュリン / 眼内血管新生 / 増殖糖尿病網膜症 / 血管新生緑内障 / 未熟児網膜症 / VEGF / SDF1α / 造血幹細胞 / 血管前駆細胞 / 抗VEGF抗体 / 抗SDF1α抗体 / 血管線維増殖膜 / SDF1□ / 血管血管 / 新生血管増殖膜 |
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| Research Abstract |
In addition to the previously reported vascular endothelial growth factor, Stromal cell-derived factor 1α(SDF-1α) and its inducing endothelial progenitor cells can play important roles in neovascularization and vascular maturation in a variety of intraocular neovascular diseases such as proliferative diabetic retinopathy and neovascular glaucoma. The tendon-derived anti-angiogenic factor, tenomodulin, can suppress the intraocular neovascular activities via the interaction with these factors.
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Report
(4 results)
Research Products
(26 results)
