Pathogenesis of age-related macular degeneration. involvement of lipid peroxidation by photic stress and innate immunity
| Project/Area Number |
21592231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
KAMEI Motohiro 大阪大学, 医学系・研究科, 准教授 (40281125)
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| Co-Investigator(Kenkyū-buntansha) |
GOMI Fumi 大阪大学, 医学系・研究科, 講師 (80335364)
TSUJIKAWA Motokazu 大阪大学, 医学系・研究科, 助教 (70419472)
SAKAGUCHI Hirokazu 大阪大学, 医学系・研究科, 助教 (80379172)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 加齢黄斑変性 / 酸化ストレス / 脂質酸化 / 自然免疫 / 光照射 |
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| Research Abstract |
The long term aim of this research is to reveal the pathogenesis of age-related macular degeneration(AMD) and develop a radical treatment. We successfully developed a new animal model of AMD which is similar to human AMD, by irradiating a low. intensity blue light for a long term(^~ 6 months). We demonstrated an involvement of lipid peroxidation by this photic stress and a chronic inflammation. We also investigated an involvement of innate immunity to the development of AMD, and found that a pretreatment with low dose lipopolysaccharide, the major component of the bacteria wall suppressed the development of choroidal neovascularization, and revealed that IL-10 plays an important role in the mechanism of this immune modification.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration2012
Author(s)
Suzuki M, Tsujikawa M, Itabe H, Du ZJ, Xie P, Matsumura N, Fu X, Zhang R, Son oda K, Egashira K, Hazen S, Kamei M
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Journal Title
J Cell Sci
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Chronic photo-oxidative stress and subsequent MCP-1 activation as causative factors for age-related macular degeneration2012
Author(s)
Suzuki M, Tsujikawa M, Itabe H, Du ZJ, Xie P, Matsumura N, Fu X, Zhang R, Sonoda KH, Egashira K, Hazen SL, Kamei M
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Journal Title
J Cell Sci
Volume: Feb
Pages: 2407-2415
DOI
Related Report
Peer Reviewed
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[Journal Article] Testing of semi-chronically implanted retinal prosthesis by suprachoroidal-transretinal stimulation in patients with retinitis pigmentosa2011
Author(s)
Fujikado T, Kamei M, Sakaguchi H, Kanda H, Morimoto T, Ikuno Y, Nishida K, Kishima H, Maruo T, Konoma K, Ozawa M, Nishida K
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Journal Title
Invest Ophthalmol
Volume: 52(7)
Pages: 4726-33
Related Report
Peer Reviewed
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[Journal Article] Chronic implantation of newly developed suprachoroidal-transretinal stimulation prosthesis in dogs2011
Author(s)
Morimoto T, Kamei M, Nishida K, Sakaguchi H, Kanda H, Ikuno Y, Kishima H, Maruo T, Konoma K, Ozawa M, Nishida K, Fujikado T
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52(9)
Pages: 6785-92
Related Report
Peer Reviewed
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[Presentation] Surgical Approach for Semi-chronic Implantation of Retinal Prosthesis by Suprachoroidal-Transretinal Stimulation (STS) in Patients with Retinitis Pigmentosa2011
Author(s)
Sakaguchi H, Kamei M, Nishida K, Ikuno Y, Morimoto T, Kishima H, Maruo T, Ozawa M, Fujikado T, Nishida K
Organizer
The Association for Research in Vision and Ophthalmology
Place of Presentation
Fort Lauderdale, FL, USA(招待講演)
Year and Date
2011-05-04
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