| Project/Area Number |
21592231
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka University |
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Principal Investigator |
KAMEI Motohiro 大阪大学, 医学系・研究科, 准教授 (40281125)
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| Co-Investigator(Kenkyū-buntansha) |
GOMI Fumi 大阪大学, 医学系・研究科, 講師 (80335364)
TSUJIKAWA Motokazu 大阪大学, 医学系・研究科, 助教 (70419472)
SAKAGUCHI Hirokazu 大阪大学, 医学系・研究科, 助教 (80379172)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 加齢黄斑変性 / 酸化ストレス / 脂質酸化 / 自然免疫 / 光照射 |
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| Research Abstract |
The long term aim of this research is to reveal the pathogenesis of age-related macular degeneration(AMD) and develop a radical treatment. We successfully developed a new animal model of AMD which is similar to human AMD, by irradiating a low. intensity blue light for a long term(^~ 6 months). We demonstrated an involvement of lipid peroxidation by this photic stress and a chronic inflammation. We also investigated an involvement of innate immunity to the development of AMD, and found that a pretreatment with low dose lipopolysaccharide, the major component of the bacteria wall suppressed the development of choroidal neovascularization, and revealed that IL-10 plays an important role in the mechanism of this immune modification.
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