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Pathogenesis of abnormal fundus autofluorescence and its relevance to age-related macular degeneration

Research Project

Project/Area Number 21592236
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionNagoya City University

Principal Investigator

YASUKAWA Tsutomu  名古屋市立大学, 大学院・医学研究科, 准教授 (00324632)

Co-Investigator(Kenkyū-buntansha) OGURA Yuichiro  名古屋市立大学, 大学院・医学研究科, 教授 (70191963)
NOZAKI Miho  名古屋市立大学, 大学院・医学研究科, 講師 (00295601)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords眼細胞生物学 / 加齢黄斑変性 / 家兎 / 眼底異常自発蛍光 / 網膜色素上皮 / リポフスチン / 家兔
Research Abstract

Age-related macular degeneration(AMD) is a major cause of legal blindness in the adult. Understanding of aging changes in eyes may be required to elucidate the pathogenesis of AMD and develop new prophylactic modalities. The first senescent change in the eye is the accumulation of lipofuscin, granules refractory to lysosomal degradation into retinal pigment epithelial cells. In this study, the rabbit AMD model was developed by injecting imitation lipofuscin into the subretinal space. This model revealed abnormal fundus autofluorescence similar to the findings observed in human aging eyes with or without AMD. This model mimicked the pathology of AMD and might be useful to elucidate the biogenesis of abnormal fundus autofluorescence and the pathogenesis of AMD.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (18 results)

All 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 11 results) Presentation (7 results)

  • [Journal Article] Recent advances in intraocular drug delivery systems2011

    • Author(s)
      Yasukawa T, Tabata Y, Kimura H, Ogura Y
    • Journal Title

      Recent Pat Drug Deliv Formul

      Volume: 5 Pages: 1-10

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ocular drug delivery for bioactive protein2011

    • Author(s)
      Yasukawa T, Tabata Y, Kimura H, Ogura Y
    • Journal Title

      Expert Rev Ophthalmol

      Volume: 6 Pages: 657-667

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pneumatic displacement of submacular hemorrhage with or without tissue plasminogen activator2011

    • Author(s)
      Mizutani T, Yasukawa T, Ito Y, Takase A, Hirano Y, Yoshida M, Ogura Y
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 249 Pages: 1153-1157

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anti-angiogenic effects of the receptor tyrosine kinase inhibitor, pazopanib, on choroidal neovascularization in rats2011

    • Author(s)
      Yafai Y, Yang XM, Niemeyer M, Nishiwaki A, Lange J, Wiedemann P, King AG, Yasukawa T, Eichler W
    • Journal Title

      Eur J Pharmacol

      Volume: 666 Pages: 12-18

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Recent advances in intraocular drug delivery systems.2011

    • Author(s)
      Yasukawa T, et al.
    • Journal Title

      Recent Pat Drug Deliv Formul.

      Volume: 5 Pages: 1-10

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Medical devices for the treatment of eye diseases2010

    • Author(s)
      Yasukawa T, Ogura Y
    • Journal Title

      Handb Exp Pharmacol

      Volume: 197 Pages: 469-489

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Indocyanine green angiography-guided laser photocoagulation combined with sub-tenon's capsule injection of triamcinolone acetonide for idiopathic macular telangiectasia2010

    • Author(s)
      Hirano Y, Yasukawa T, Usui Y, Nozaki M, Ogura Y
    • Journal Title

      Br J Ophthalmol

      Volume: 94 Pages: 600-605

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inflammation in age-related macular degeneration : pathological or physiological? Editorial2009

    • Author(s)
      Yasukawa T
    • Journal Title

      Expert Rev Ophthalmol

      Volume: 4 Pages: 107-112

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fundus autofluorescence and fate of glycoxidized particles injected into subretinal space in rabbit age-related macular degeneration model2009

    • Author(s)
      Hirata M, Yasukawa T, Wiedemann P, Kimura E, Kunou N, Eichler W, Takase A, Sato R, Ogura Y
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol

      Volume: 247 Pages: 929-937

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Intraocular pressure elevation following triamcinolone acetonide administration as related to administration routes2009

    • Author(s)
      Hirano Y, Ito T, Nozaki M, Yasukawa T, Sakurai E, Yoshida M, Ogura Y
    • Journal Title

      Jpn J Ophthalmol

      Volume: 53 Pages: 519-522

    • NAID

      10025865218

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fundus autofluorescence and fate of glycoxidized particles injected into subretinal space in rabbit age-related macular degeneration model2009

    • Author(s)
      Hirata M, Yasukawa T, et al.
    • Journal Title

      Graefes Arch Clin Exp Ophthalmol 247

      Pages: 929-937

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 加齢黄斑変性初期病態に関する臨床研究報告(2)-眼底異常所見と網膜感度の関連-2010

    • Author(s)
      安川力
    • Organizer
      第64回日本臨床眼科学会
    • Place of Presentation
      神旨ポートピアホテル(兵庫)
    • Year and Date
      2010-11-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] JFAMスタディグループ:加齢黄斑変性初期病態に関する臨床研究報告(2)-眼底異常所見と網膜感度の関連-(加齢黄斑変性初期病態調査(2))2010

    • Author(s)
      安川力
    • Organizer
      第64回日本臨床眼科学会
    • Place of Presentation
      神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] In vitro drusen model : 3D-spheroid culture of retinal pigment epithelial cells2010

    • Author(s)
      Yasukawa T, Wiedemann P, Ogura Y
    • Organizer
      27^<th> meeting of the Club Jules Gonin
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2011 Final Research Report
  • [Presentation] Drug delivery systems for treatment of macular diseases. Symposium. Advances in molecular biology of macular diseases2010

    • Author(s)
      Yasukawa T
    • Organizer
      The 25^<th> Congress of APAO
    • Place of Presentation
      Beijing, China
    • Related Report
      2011 Final Research Report
  • [Presentation] 異常眼底自発蛍光の発生機序と加齢黄斑変性との関連2009

    • Author(s)
      安川力
    • Organizer
      第113回日本眼科学会総会
    • Place of Presentation
      東京国際フォーラム(東京都)
    • Year and Date
      2009-04-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Multicellular spheroid culture of retinal pigment epithelial cells enhancing differentiation as an epithelium and formation of Bruch's membrane2009

    • Author(s)
      Yasukawa T, Wiedemann P, Wolfram E, Yafai Y, Nishiwaki A, Bringmann A, Ogura Y
    • Organizer
      107th DOG Congress
    • Place of Presentation
      Leipzig
    • Related Report
      2011 Final Research Report
  • [Presentation] Three-dimensional spheroid culture visualizing membranogenesis of Bruch's membrane and basal functions of retinal pigment epithelium2009

    • Author(s)
      Yasukawa T, Wiedemann P, Nishiwaki A, Takase A, Sato R, Ogura Y
    • Organizer
      The 24^<th> Congress of APAO
    • Place of Presentation
      Bali, Indonesia
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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