| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
Age-related macular degeneration(AMD) is a major cause of legal blindness in the adult. Understanding of aging changes in eyes may be required to elucidate the pathogenesis of AMD and develop new prophylactic modalities. The first senescent change in the eye is the accumulation of lipofuscin, granules refractory to lysosomal degradation into retinal pigment epithelial cells. In this study, the rabbit AMD model was developed by injecting imitation lipofuscin into the subretinal space. This model revealed abnormal fundus autofluorescence similar to the findings observed in human aging eyes with or without AMD. This model mimicked the pathology of AMD and might be useful to elucidate the biogenesis of abnormal fundus autofluorescence and the pathogenesis of AMD.
|
