Investigation of epigenetic factors in the pathogenesis of glucocorticoid-induced glaucoma
| Project/Area Number |
21592239
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Juntendo University |
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Principal Investigator |
MATSUDA Akira 順天堂大学, 医学研究科, 准教授 (00312348)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Satoshi 京都府立医科大学, 医学研究科, 助教 (60347458)
MORI Kakuhiko 京都府立医科大学, 医学研究科, 講師 (40252001)
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| Co-Investigator(Renkei-kenkyūsha) |
TASHIRO Kei 京都府立医科大学, 医学研究科, 教授 (10263097)
IKEDA Youko 京都府立医科大学, 医学研究科, 助教 (00433243)
KINOSHITA Shigeru 京都府立医科大学, 医学研究科, 教授 (30116024)
MARUYAMA Kazuichi 京都府立医科大学, 医学研究科, 助教 (10433244)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | エピジェネティクス / 緑内障 / ステロイド / ゲノム / 遺伝子多型 / ステロイド緑内障 / ゲノムメチル化 |
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| Research Abstract |
The effects for dexamethasone(DEX) treatment for the genomic methylation status of human trabecular meshwork cells were analyzed by whole genome methylation array analysis. DEX treatment changed the expression level of 23 genes significantly. We analyzed the functional effect of genomic methylation/demethylation of RICS, RGS6 and GPR126 and found that the change of methylation status did affect not only the quantitative expression level but also qualitative expression pattern like the change of mRNA splicing.
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Report
(4 results)
Research Products
(23 results)
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[Journal Article] Basophils in the giant papillae of chronic allergic keratoconjunctivitis2010
Author(s)
Matsuda A, Ebihara N, Yokoi N, Okayama Y, Watanabe Y, Kawasaki S, Tanioka H, Walls AF, Hamuro J, Kinoshita S, Murakami A.
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Journal Title
Br J Ophthalmol
Volume: 94
Pages: 513-518
Related Report
Peer Reviewed
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[Journal Article] Three susceptible loci associated with primary-open angle glaucoma identified by genome-wide association study in Japanese population2009
Author(s)
Nakano M, Ikeda Y, Taniguchi T, Yagi T, Fuwa M, Omi N, Tokuda Y, Tanaka M, Yoshii K, Kageyama M, Naruse S, Matsuda A, Mori K, Kinoshita S, Tashiro K.
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Journal Title
Proc Natl Acad
Volume: 106
Pages: 12838-12842
Related Report
Peer Reviewed
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[Journal Article] The Role of Interleukin-33 in Chronic Allergic Conjunctivitis2009
Author(s)
Matsuda A, Okayama Y, Terai N, Yokoi N, Ebihara N, Tanioka H, Kawasaki S, Inatomi T, Katoh N, Ueda E, Hamuro J, Murakami A, Kinoshita S.
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Journal Title
Invest Ophthalmol
Volume: 50
Pages: 4646-4652
Related Report
Peer Reviewed
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[Journal Article] Involvement of Plasminogen Activator Inhibitor-1 in the Pathogenesis of Atopic Cataracts
Author(s)
Hori K, Matsuda A, Ebihara N, Imai K, Mori K, Funaki T, Watanabe Y, Nakatani S, Okada K, Matsuo O, Murakami A.
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Journal Title
Invest Ophthalmol
Volume: (in Press)
Related Report
Peer Reviewed
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