| Project/Area Number |
21592239
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Juntendo University |
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Principal Investigator |
MATSUDA Akira 順天堂大学, 医学研究科, 准教授 (00312348)
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| Co-Investigator(Kenkyū-buntansha) |
KAWASAKI Satoshi 京都府立医科大学, 医学研究科, 助教 (60347458)
MORI Kakuhiko 京都府立医科大学, 医学研究科, 講師 (40252001)
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| Co-Investigator(Renkei-kenkyūsha) |
TASHIRO Kei 京都府立医科大学, 医学研究科, 教授 (10263097)
IKEDA Youko 京都府立医科大学, 医学研究科, 助教 (00433243)
KINOSHITA Shigeru 京都府立医科大学, 医学研究科, 教授 (30116024)
MARUYAMA Kazuichi 京都府立医科大学, 医学研究科, 助教 (10433244)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | エピジェネティクス / 緑内障 / ステロイド / ゲノム / 遺伝子多型 / ステロイド緑内障 / ゲノムメチル化 |
|---|
| Research Abstract |
The effects for dexamethasone(DEX) treatment for the genomic methylation status of human trabecular meshwork cells were analyzed by whole genome methylation array analysis. DEX treatment changed the expression level of 23 genes significantly. We analyzed the functional effect of genomic methylation/demethylation of RICS, RGS6 and GPR126 and found that the change of methylation status did affect not only the quantitative expression level but also qualitative expression pattern like the change of mRNA splicing.
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