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Investigation of epigenetic factors in the pathogenesis of glucocorticoid-induced glaucoma

Research Project

Project/Area Number 21592239
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionJuntendo University

Principal Investigator

MATSUDA Akira  順天堂大学, 医学研究科, 准教授 (00312348)

Co-Investigator(Kenkyū-buntansha) KAWASAKI Satoshi  京都府立医科大学, 医学研究科, 助教 (60347458)
MORI Kakuhiko  京都府立医科大学, 医学研究科, 講師 (40252001)
Co-Investigator(Renkei-kenkyūsha) TASHIRO Kei  京都府立医科大学, 医学研究科, 教授 (10263097)
IKEDA Youko  京都府立医科大学, 医学研究科, 助教 (00433243)
KINOSHITA Shigeru  京都府立医科大学, 医学研究科, 教授 (30116024)
MARUYAMA Kazuichi  京都府立医科大学, 医学研究科, 助教 (10433244)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsエピジェネティクス / 緑内障 / ステロイド / ゲノム / 遺伝子多型 / ステロイド緑内障 / ゲノムメチル化
Research Abstract

The effects for dexamethasone(DEX) treatment for the genomic methylation status of human trabecular meshwork cells were analyzed by whole genome methylation array analysis. DEX treatment changed the expression level of 23 genes significantly. We analyzed the functional effect of genomic methylation/demethylation of RICS, RGS6 and GPR126 and found that the change of methylation status did affect not only the quantitative expression level but also qualitative expression pattern like the change of mRNA splicing.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (23 results)

All 2012 2011 2010 2009 Other

All Journal Article (18 results) (of which Peer Reviewed: 18 results) Presentation (5 results)

  • [Journal Article] Involvement of Plasminogen Activator Inhibitor-1 in the Pathogenesis of Atopic Cataracts2012

    • Author(s)
      Hori K, Matsuda A, et al
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: (In Press) Issue: 4 Pages: 1846-1851

    • DOI

      10.1167/iovs.11-8380

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perlecan-Deficient Mutation Impairs Corneal Epithelial Structure2012

    • Author(s)
      Inomata T, Ebihara N, et al
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: (In Press) Issue: 3 Pages: 1277-84

    • DOI

      10.1167/iovs.11-8742

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the IL-6 classic and trans-signaling pathways in corneal sterile inflammation and wound healing2011

    • Author(s)
      Ebihara N, Matsuda A, et al
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 52 Issue: 12 Pages: 8549-57

    • DOI

      10.1167/iovs.11-7956

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two novel mutations identified in three Japanese gelatinous drop-like corneal dystrophy families2011

    • Author(s)
      Nakatsukasa M, Kawasaki S, et al
    • Journal Title

      Mol Vis

      Volume: 17 Pages: 950-970

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis2010

    • Author(s)
      Matsuda A, Ebihara N, Yokoi N, Maruyama K, Hamuro J, Kinoshita S, Murakami A.
    • Journal Title

      J Allergy Clin Immunol

      Volume: 126 Pages: 1310-1312

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Basophils in the giant papillae of chronic allergic keratoconjunctivitis2010

    • Author(s)
      Matsuda A, Ebihara N, Yokoi N, Okayama Y, Watanabe Y, Kawasaki S, Tanioka H, Walls AF, Hamuro J, Kinoshita S, Murakami A.
    • Journal Title

      Br J Ophthalmol

      Volume: 94 Pages: 513-518

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Murakami A. Functional Roles of Thymic Stromal Lymphopoietin for Chronic Allergic Keratoconjunctivitis2010

    • Author(s)
      Matsuda A, Ebihara N, Yokoi N, Kawasaki S, Tanioka H, Inatomi T, de Waal Malefyt R, Hamuro J, Kinoshita S
    • Journal Title

      Invest Ophthalmol

      Volume: 51 Pages: 151-155

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional role of thymic stromal lymphopoietin in chronic allergic keratoconjunctivitis.2010

    • Author(s)
      Matsuda A, et al
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 51 Pages: 151-155

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Basophils in the giant papillae of chronic allergic keratoconjunctivitis.2010

    • Author(s)
      Matsuda A, et al
    • Journal Title

      Br J Ophthalmol

      Volume: 94 Pages: 513-518

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Lymphoid neogenesis in the giant papillae of patients with chronic allergic conjunctivitis.2010

    • Author(s)
      Matsuda A, et al
    • Journal Title

      J Allergy Clin Immunol

      Volume: 126 Pages: 1310-1312

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three susceptible loci associated with primary-open angle glaucoma identified by genome-wide association study in Japanese population2009

    • Author(s)
      Nakano M, Ikeda Y, Taniguchi T, Yagi T, Fuwa M, Omi N, Tokuda Y, Tanaka M, Yoshii K, Kageyama M, Naruse S, Matsuda A, Mori K, Kinoshita S, Tashiro K.
    • Journal Title

      Proc Natl Acad

      Volume: 106 Pages: 12838-12842

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Interleukin-33 in Chronic Allergic Conjunctivitis2009

    • Author(s)
      Matsuda A, Okayama Y, Terai N, Yokoi N, Ebihara N, Tanioka H, Kawasaki S, Inatomi T, Katoh N, Ueda E, Hamuro J, Murakami A, Kinoshita S.
    • Journal Title

      Invest Ophthalmol

      Volume: 50 Pages: 4646-4652

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hyperexpression of the high-affinity IgE receptor-β chain in chronic allergic keratoconjunctivitis2009

    • Author(s)
      Matsuda A, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci 50

      Pages: 2871-2877

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Role of Interleukin-33 in Chronic Allergic Conjunctivitis2009

    • Author(s)
      Matsuda A, et al.
    • Journal Title

      Invest Ophthalmol Vis Sci 50

      Pages: 4646-452

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three susceptible loci associated with primary-open angle glaucoma identified by genome-wide association study in Japanese population2009

    • Author(s)
      Nakano M, et al.
    • Journal Title

      Proc Ntal Acad Sci USA 106

      Pages: 12838-12842

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of Plasminogen Activator Inhibitor-1 in the Pathogenesis of Atopic Cataracts

    • Author(s)
      Hori K, Matsuda A, Ebihara N, Imai K, Mori K, Funaki T, Watanabe Y, Nakatani S, Okada K, Matsuo O, Murakami A.
    • Journal Title

      Invest Ophthalmol

      Volume: (in Press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Perlecan-Deficient Mutation Impairs Corneal Epithelial Structure

    • Author(s)
      Inomata T, Ebihara N, Funaki T, Matsuda A, Watanabe Y, Ning L, Xu Z, Murakami A, Arikawa-Hirasawa A.
    • Journal Title

      Invset Ophthalmol

      Volume: (in Press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Role of the IL-6 classic and trans-signaling pathways in corneal sterile inflammation and wound healing

    • Author(s)
      Ebihara N, Matsuda A, Nakamura S, Matsuda H and Murakami A.
    • Journal Title

      Invset Ophthalmol

      Volume: (in Press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] アトピー緑内障の臨床像2011

    • Author(s)
      松田彰, 他
    • Organizer
      第65回日本臨床眼科学会
    • Place of Presentation
      東京(国際フォーラム)
    • Year and Date
      2011-10-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 線維柱帯細胞のゲノムメチル化2010

    • Author(s)
      松田彰, 他
    • Organizer
      第21回日本緑内障学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-09-25
    • Related Report
      2010 Annual Research Report
  • [Presentation] デキサメサゾンによるヒト培養線維柱帯細胞のゲノムメチル化状態の変化2010

    • Author(s)
      松田彰、海老原伸行、村上晶
    • Organizer
      第21回日本緑内障学会
    • Place of Presentation
      福岡
    • Year and Date
      2010-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Th2サイトカイン環境は結膜繊維芽細胞のコラーゲンゲル収縮能を増加させる2009

    • Author(s)
      松田彰、海老原伸行、村上晶
    • Organizer
      第20回日本緑内障学会
    • Place of Presentation
      沖縄
    • Year and Date
      2009-11-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Th2サイトカイン環境は結膜繊維芽細胞のコラーゲンゲル収縮能を増加させる2009

    • Author(s)
      松田彰, 他
    • Organizer
      日本緑内障学会
    • Place of Presentation
      沖縄県那覇市
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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