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Development of the new treatment strategy through the TRP channel to severe neurotrophic keratopathy and alkali burn in cornea

Research Project

Project/Area Number 21592241
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionWakayama Medical University

Principal Investigator

OKADA Yuka  和歌山県立医科大学, 医学部, 講師 (50264891)

Co-Investigator(Kenkyū-buntansha) SAIKA Shizuya  和歌山県立医科大学, 医学部, 教授 (40254544)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords角膜 / 創傷治癒 / TRPチャンネル / TRP / 炎症 / 三叉神経
Research Abstract

Absence or blocking TRP channels suppressed inflammation and fibrosis/sacrring during healing of alkali-burnec cornea. Systemic TRP channel antagonists reproduced the KO-type of healing. In conclusion, absence or blocking of TRPV1 suppressed inflammation and fibrosis/scarring during healing of severe neurotrophic keratopaty and alkali burn in cornea.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (29 results)

All 2012 2011 2010 2009

All Journal Article (11 results) (of which Peer Reviewed: 9 results) Presentation (18 results)

  • [Journal Article] TRPV1 involvement in inflammatory tissue fibrosis in mice2011

    • Author(s)
      Okada Y, Reinach PS, Shirai K, Kitano A, Kao WW, Flanders KC, Miyajima M, Liu H, Zhang J, Saika S
    • Journal Title

      Am J Pathol

      Volume: 178(6) Pages: 2654-64

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] 【ケアの違いはここにある!糖尿病VS非糖尿病】ケアする 症状と合併症 ケアの違いはここにある 視力障害(解説/特集)2010

    • Author(s)
      岡田由香
    • Journal Title

      透析ケア

      Volume: 16(7) Pages: 742-745

    • Related Report
      2010 Annual Research Report
  • [Journal Article] Therapeutic potential of trichostatin A to control inflammatory and fibrogenic disorders of the ocular surface.2010

    • Author(s)
      Kitano A, Okada Y, Yamanka O, Shirai K, Mohan RR, Saika S
    • Journal Title

      Mol Vis.

      Volume: 31;16 Pages: 2964-73

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired angiogenic response in the cornea of mice lacking tenascin C.2010

    • Author(s)
      Sumioka T, Fujita N, Kitano A, Okada Y, Saika S.
    • Journal Title

      Invest Ophthalmol Vis Sci

      Volume: 18(Epub ahead of print)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of injury-induced epithelial-mesenchymal transition in a mouse lens epithelium lacking tenascin-C.2010

    • Author(s)
      Tanaka S, Sumioka T, Fujita N, Kitano A, Okada Y, Yamanaka O, Flanders KC, Miyajima M, Saika S.
    • Journal Title

      Mol Vis

      Volume: 1;16 Pages: 1194-205

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Two Cases of Congenital Retrobulbar Cyst or Peripapillary Staphyloma with an Alcoholic Mother.2010

    • Author(s)
      Kitano A, Shirai K, Okada Y, Saika S.
    • Journal Title

      J Pediatr Ophthalmol Strabismus.

      Volume: 26 Pages: 1-5

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical observation of anterior subcapsular cataract in eye with spontaneously regressed retinoblastoma2010

    • Author(s)
      Shirai K, Okada Y, Saika S.
    • Journal Title

      J Cataract Refract Surg.

      Volume: 36(3) Pages: 503-7

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired angiogenic response in the corneas of mice lacking osteopontin.2010

    • Author(s)
      Fujito N, Fujito S, Okada Y, Fujita K, Kitano A, Yamanaka O, Miyamoto T, Kon S, Uede T
    • Journal Title

      Invest Ophthalmol Vis Sci.

      Volume: 51(2) Pages: 790-4

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 免疫再構築症候群の一例2010

    • Author(s)
      洪成勲, 岡田由香, 雑賀司珠也
    • Journal Title

      眼科臨床紀要

      Volume: 3(8) Pages: 768-770

    • NAID

      10030250889

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neurotrophic keratopathy ; its pathophysiology and treatment.2010

    • Author(s)
      Okada Y, Reinach PS, Kitano A, Shirai K, Kao WW, Saika S.
    • Journal Title

      Histol Histopathol.

      Volume: 25(6) Pages: 771-80

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transforming growth factor beta signal transduction : a potential target for maintenance/restoration of transparency of the cornea.2010

    • Author(s)
      Saika S, Yamanaka O, Sumioka T, Okada Y, Miyamoto T, Shirai K, Kitano A, Tanaka S.
    • Journal Title

      Eye Contact Lens.

      Volume: 36(5) Pages: 286-9

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス三叉神経障害モデルの角膜創傷治癒2012

    • Author(s)
      岡田由香、白井久美、藤田識人, 泉谷愛、仙波恵美子、雑賀司珠也
    • Organizer
      角膜カンファランス2012
    • Place of Presentation
      東京
    • Year and Date
      2012-02-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] TRP receptors and corneal inflammation2012

    • Author(s)
      Okada Y, Reinach P, Shirai K, Kitano A. Saika S
    • Organizer
      Gordon Reserch Conferences
    • Place of Presentation
      Ventura. USA
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス三叉神経障害モデルの作製2011

    • Author(s)
      岡田由香、仙波恵美子、白井久美、藤田識人、北野愛、雑賀司珠也
    • Organizer
      第115回日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-05-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of loss of TRPV4 on the inflammation and scarring of analkali-burned cornea in mice2011

    • Author(s)
      Yuka Okada, Peter S, Reinach, Kumi Shirai, Ai Kitano, Masayasu Miyajima, Shizuya Saika
    • Organizer
      ARVO
    • Place of Presentation
      フロリダ
    • Year and Date
      2011-05-02
    • Related Report
      2011 Annual Research Report
  • [Presentation] Effects of loss of TRPV4 on the inflammation and scarring of an alkali-burned cornea in mice2011

    • Author(s)
      Okada Y, Reinach P, Shirai S, Kitano A, Miyajima M, Saika S
    • Organizer
      ARVO
    • Place of Presentation
      Ft. lauderdale USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Thermosensitive ion channel receptors and corneal inflammation2010

    • Author(s)
      Yuka Okada, Peter Reinach, Kumi Shirai, Ai Kitano, Masayasu Miyajima, Winston W.-Y.Kao, Shizuya Saika
    • Organizer
      日韓ジョイント角膜カンファランス
    • Place of Presentation
      京都
    • Year and Date
      2010-12-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] Modulation of inflammation in corneal etroma by ion channel signaling2010

    • Author(s)
      Yuka Okada, Peter Reinach, Kumi Shirai, Ai Kitano, Masayasu Miyajima, Winston W.-Y.Kao, Shizuya Saika
    • Organizer
      International Congress of Eye Research
    • Place of Presentation
      モントリオール
    • Year and Date
      2010-07-19
    • Related Report
      2010 Annual Research Report
  • [Presentation] TRPA1 gene ablation in mice improves corneal wound healing response to injury2010

    • Author(s)
      Yuka Okada, Peter Reinach, Kumi Sirai, Ai Kitano, Masayasu Miyajima, Shizuya saika
    • Organizer
      The Association for Research in Vision and Ophthalmology
    • Place of Presentation
      フォートローダーデール
    • Year and Date
      2010-05-04
    • Related Report
      2010 Annual Research Report
  • [Presentation] TRPV4欠損の角膜アルカリ外傷に及ぼす影響2010

    • Author(s)
      岡田由香, ピーター・ライナック, 白井久美, 北野愛, 宮嶋正康, 雑賀司珠也
    • Organizer
      日本眼科学会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-04-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] TRPA1欠損の角膜アルカリ外傷に及ぼす影響2010

    • Author(s)
      岡田由香, ピーターライナック, 白井久美, 北野愛, 宮嶋正康, 雑賀真珠也
    • Organizer
      角膜カンファランス
    • Place of Presentation
      仙台
    • Year and Date
      2010-02-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Thermosensitive ion channel receptors and corneal inflammation2010

    • Author(s)
      Okada Y, Reinach P, Shirai K, Kitani A, Miyajima M, Kao WW, Saika S
    • Organizer
      2010 Korea-Japan Joint Cornea Conference
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] TRPV4 gene ablation in mice improves corneal wound healing response to injury2010

    • Author(s)
      Okada Y, Reinach P, Shirai K, Kitani A, Miyajima M, Kao WW, Saika S
    • Organizer
      The 2^<nd> Asia Cornea Society Biennial Scientific Meeting
    • Place of Presentation
      Kyoto
    • Related Report
      2011 Final Research Report
  • [Presentation] Modulation of inflammation in corneal stroma by ion channel signaling2010

    • Author(s)
      Okada Y, Reonach P, Shirai K, Kitano A, Miyajima M, Kao WW, Saika S
    • Organizer
      ICER
    • Place of Presentation
      Montreal Canada
    • Related Report
      2011 Final Research Report
  • [Presentation] TRPA1 gene ablation in mice improves corneal wound healing response to injury2010

    • Author(s)
      Okada Y, Reinach P, Shirai K, Kitano A, Miyajima M, Saika S
    • Organizer
      ARVO
    • Place of Presentation
      Ft. lauderdale USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Loss of mouse TRPV1 function improves corneal wound healing response to alkali-burn injury2010

    • Author(s)
      Okada Y, Saika S, Shirai, K, Kitano A, Miyajima M, Kao WW, Reinach P
    • Organizer
      Gordon Reserch Conferences
    • Place of Presentation
      Ventura. USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of loss of TRPV1 on the inflammation after an alkali-burned cornea in mice2009

    • Author(s)
      Yuka Okada, Shizuya Saika, Kumi Shirai, Ai Kitano, Masayasu Miyajima, Peter Reinach
    • Organizer
      ARVO
    • Place of Presentation
      フロリダ
    • Year and Date
      2009-05-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] TRPV1受容体阻害薬のマウス角膜アルカリ外傷後の治癒への効果2009

    • Author(s)
      岡田由香, ピーターライナック北野愛, 白井久美, 宮嶋正康, 雑賀真珠也
    • Organizer
      日本眼科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-04-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Effects of loss of TRPV1 on the inflammation after an alkali-burned cornea in mice2009

    • Author(s)
      Okada Y, Saika S, Shirai K, KJitano A, Miyajima M, Reinach P
    • Organizer
      ARVO
    • Place of Presentation
      Ft. lauderdale USA
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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