Development of the new treatment strategy through the TRP channel to severe neurotrophic keratopathy and alkali burn in cornea
Project/Area Number |
21592241
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
|
Research Institution | Wakayama Medical University |
Principal Investigator |
OKADA Yuka 和歌山県立医科大学, 医学部, 講師 (50264891)
|
Co-Investigator(Kenkyū-buntansha) |
SAIKA Shizuya 和歌山県立医科大学, 医学部, 教授 (40254544)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 角膜 / 創傷治癒 / TRPチャンネル / TRP / 炎症 / 三叉神経 |
Research Abstract |
Absence or blocking TRP channels suppressed inflammation and fibrosis/sacrring during healing of alkali-burnec cornea. Systemic TRP channel antagonists reproduced the KO-type of healing. In conclusion, absence or blocking of TRPV1 suppressed inflammation and fibrosis/scarring during healing of severe neurotrophic keratopaty and alkali burn in cornea.
|
Report
(4 results)
Research Products
(29 results)