Protective effects of yellow intraocular lens implantation on light-induced photoreceptor damage in mice

• Project/Area Number: 21592243
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Hokkaido University
• Principal Investigator: ISHIDA Susumu 北海道大学, 大学院・医学研究科, 教授 (10245558)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: 眼科学 / 網膜 / 神経保護 / 眼内レンズ / 光障害 / 眼内ケンズ

Research Abstract

Using a novel murine intraocular lens(IOL) implantation model, we studied the protective effects of colored-IOLs against light-induced retinal photo toxicity. Extra-capsular crystalline lens extraction and IOL implantation were performed in BALB/c mice by a technique similar to human cataract surgery. In contrast to the clear IOL-implanted animals, the yellow IOL-implanted animals had significantly reduced numbers of apoptotic cells and retained thickness of the outer retina, induced by light exposure. Electroretinography showed that yellow IOL implantation prevented a decrease of amplitude in both the a-wave and b-wave compared with clear IOL implantation. We demonstrated the protective effects of colored-IOL against retinal phototoxicity after cataract surgery.

Research Products

• [Journal Article] Biological role of lutein in the light-induced retinal degeneration (2012)
  • Author(s): Sasaki M, Yuki K, Kurihara T, Miyake S, Noda K, Kobayashi S, Ishida S, Tsubota K, Ozawa Y.
  • Journal Title: J Nutr Biochem Volume: 23 Issue: 5 Pages: 423-429
  • DOI: 10.1016/j.jnutbio.2011.01.006
  • Peer Reviewed
• [Journal Article] Roles of AMP-activated protein kinase in diabetes-induced retinal inflammation (2011)
  • Author(s): Kubota S, Ozawa Y, Kurihara T, Sasaki M, Yuki K, Miyake S, Noda K, Ishida S, Tsubota K.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Issue: 12 Pages: 9142-9148
  • DOI: 10.1167/iovs.11-8041
  • Peer Reviewed
• [Journal Article] Retinal ganglion cell loss in superoxide dismutase 1-deficiency (2011)
  • Author(s): Yuki K, Ozawa Y, Yoshida T, Kurihara T, Hirasawa M, Ozeki N, Shiba D, Noda K, Ishida S, Tsubota K.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Issue: 7 Pages: 4143-4150
  • DOI: 10.1167/iovs.10-6294
  • Peer Reviewed
• [Journal Article] Transcriptional factors associated with epithelial-mesenchymal transition in choroidal neovascularization (2011)
  • Author(s): Hirasawa M, Noda K, Noda S, Suzuki M, Ozawa Y, Shinoda K, Inoue M, Ogawa Y, Tsubota K, Ishida S.
  • Journal Title: Mol Vis Volume: 17 Pages: 1222-1230
  • NAID: 120005372298
  • URL: http://www.molvis.org/molvis/v17/a137
  • Peer Reviewed
• [Journal Article] Tissue factor expression in human pterygium (2011)
  • Author(s): Ando R, Kase S, Ohashi T, Dong Z, Fukuhara J, Kanda A, Murata M, Noda K, Kitaichi N, Ishida S.
  • Journal Title: Mol Vis Volume: 17 Pages: 63-69
  • NAID: 120005372296
  • URL: http://www.molvis.org/molvis/v17/a9/
  • Peer Reviewed
• [Journal Article] Conjunctival lymphoproliferative disorder (2011)
  • Author(s): Fukuhara J, Kase S, Ishijima K, Noda M, Ishida S.
  • Journal Title: Ophthalmology Volume: 118 Pages: 423-423
  • URL: http://dx.doi.org/10.1016/j.ophtha.2010.08.031
  • Peer Reviewed
• [Journal Article] Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model (2011)
  • Author(s): Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S, Umezawa K, Kurihara T, Tsubota K.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Issue: 1 Pages: 427-433
  • DOI: 10.1167/iovs.10-6167
  • Peer Reviewed
• [Journal Article] Choroidal neovascularization in a patient with blunt trauma-caused traumatic retinopathy without choroidal rupture (2011)
  • Author(s): Takahashi M, Kinoshita S, Saito W, Kase M, Ishida S
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 249 Issue: 1 Pages: 137-140
  • DOI: 10.1007/s00417-010-1472-0
  • Peer Reviewed
• [Journal Article] Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus type 54 in Japan (2011)
  • Author(s): Kaneko H, Suzutani T, Aoki K, Kitaichi N, Ishida S, Ishiko H, Ohashi T, Okamoto S, Nakagawa H, Hinokuma R, Asato Y, Oniki S, Hashimoto T, Iida T, Ohno S.
  • Journal Title: Br J Ophthalmol Volume: 95 Issue: 1 Pages: 32-36
  • DOI: 10.1136/bjo.2009.178772
  • Peer Reviewed
• [Journal Article] Tissue factor expression in human pterygium. (2011)
  • Author(s): Ando R, Kase S, Ohashi T, Dong Z, Fukuhara J, Kanda A, Murata M, Noda K, Kitaichi N, Ishida S
  • Journal Title: Mol Vis Volume: 17 Pages: 63-69
  • NAID: 120005372296
  • Peer Reviewed
• [Journal Article] Conjunctival lymphoproliferative disorder. (2011)
  • Author(s): Fukuhara J, Kase S, Ishijima K Noda M, Ishida S
  • Journal Title: Ophthalmology Volume: 118 Pages: 423-423
  • Peer Reviewed
• [Journal Article] Hydrogen and N-acetyl-L-cysteine rescue oxidative stress-induced angiogenesis in a mouse corneal alkali-burn model. (2011)
  • Author(s): Kubota M, Shimmura S, Kubota S, Miyashita H, Kato N, Noda K, Ozawa Y, Usui T, Ishida S.Umezawa K, Kurihara T, Tsubota K
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 52 Pages: 427-433
  • Peer Reviewed
• [Journal Article] Choroidal neovascularization in a patient with blunt trauma-caused traumatic retinopathy without choroidal rupture. (2011)
  • Author(s): Takahashi M, Kinoshita S, Saito W, Kase M, Ishida S
  • Journal Title: Graefes Arch Clin Exp Ophthalmol Volume: 249 Pages: 137-140
  • Peer Reviewed
• [Journal Article] Epidemiological and virological features of epidemic keratoconjunctivitis due to new human adenovirus type 54 in Japan. (2011)
  • Author(s): Kaneko H, Suzutani T, Aoki K, Kitaichi N, Ishida S, Ishiko H, Ohashi T, Okamoto S,Nakagawa H, Hinokuma R, Asato Y, Oniki S, Hashimoto T, Iida T, Ohno S
  • Journal Title: Br J Ophthalmol Volume: 95 Pages: 32-36
  • Peer Reviewed
• [Journal Article] Molecular epidemiology of adenoviral keratoconjunctivitis in Saudi Arabia (2010)
  • Author(s): Tabbara KF, Omar N, Hammouda E, Akanuma M, Ohguchi T, Ariga T, Tagawa Y, Kitaichi N, Ishida S, Aoki K, Ishiko H, Ohno S.
  • Journal Title: Mol Vis Volume: 16 Pages: 2132-2136
  • URL: http://www.molvis.org/molvis/v16/a228/
  • Peer Reviewed
• [Journal Article] Combined vitreous and cataract surgeries in highly hyperopic eye (2010)
  • Author(s): Inoue M, Shinoda K, Matsuda-Yamamitsu T, Sano RY, Ishida S.
  • Journal Title: Clin Ophthalmol Volume: 4 Pages: 1003-1005
  • NAID: 120005372302
  • URL: http://dx.doi.org/10.2147/OPTH.S13051
  • Peer Reviewed
• [Journal Article] Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis (2010)
  • Author(s): Suzuki M, Noda K, Kubota S, Hirasawa M, Ozawa Y, Tsubota K, Mizuki N, Ishida S.
  • Journal Title: Mol Vis Volume: 16 Pages: 1382-1388
  • NAID: 120002386831
  • URL: http://www.molvis.org/molvis/v16/a152
  • Peer Reviewed
• [Journal Article] Calcium channel blocker nilvadipine, but not diltiazem, inhibits ocular inflammation in endotoxin-induced uveitis (2010)
  • Author(s): Ishida S, Koto T, Nagai N, Oike Y.
  • Journal Title: Jpn J Ophthalmol Volume: 54 Issue: 6 Pages: 594-601
  • DOI: 10.1007/s10384-010-0862-5
  • NAID: 10027666392
  • Peer Reviewed
• [Journal Article] Resveratrol prevents light-induced retinal degeneration via suppressing activator protein-1 activation (2010)
  • Author(s): Kubota S, Kurihara T, Ebinuma M, Kubota M, Yuki K, Sasaki M, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K.
  • Journal Title: Am J Pathol Volume: 177 Pages: 1725-1731
  • URL: http://dx.doi.org/10.2353/ajpath.2010.100098
  • Peer Reviewed
• [Journal Article] Selective laser trabeculoplasty for elevated intraocular pressure following subtenon injection of triamcinolone acetonide. (2010)
  • Author(s): Yuki Y, Inoue M, Shiba D, Kawamura R, Ishida S, Ohtake Y.
  • Journal Title: Clin Ophthalmol Volume: 4 Pages: 247-249
  • URL: http://dx.doi.org/10.2147/OPTH.S9318
  • Peer Reviewed
• [Journal Article] Von Hippel-Lindau protein regulates transition from fetal to adult circulatory system in retina (2010)
  • Author(s): Kurihara T, Kubota Y, Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H.
  • Journal Title: Development Volume: 137 Issue: 9 Pages: 1563-1571
  • DOI: 10.1242/dev.049015
  • Peer Reviewed
• [Journal Article] Secondary macular hole formation with presumed evulsion of foveal hard exudates in a patient with diabetic retinopathy (2010)
  • Author(s): Tomita Y, Noda K, Shinoda H, Ozawa Y, Tsubota K, Ishida S.
  • Journal Title: Jpn J Ophthalmol Volume: 54 Issue: 4 Pages: 366-368
  • DOI: 10.1007/s10384-010-0823-z
  • NAID: 10027204741
  • Peer Reviewed
• [Journal Article] Neurodegenerative influence of oxidative stressin the retina of diabetic mice (2010)
  • Author(s): Sasaki M, OzawaY, Kurihara T, Kubota S, Yuki K, Noda K, Kobayashi S, Ishida S, Tsubota K.
  • Journal Title: Diabetologia Volume: 53 Issue: 5 Pages: 971-979
  • DOI: 10.1007/s00125-009-1655-6
  • Peer Reviewed
• [Journal Article] Retinal phototoxicity in a novel murine model of intraocular lens implantation (2010)
  • Author(s): Kurihara T, Omoto M, Noda K, Ebinuma M, Kubota S, Koizumi H, Yoshida S, Ozawa Y, Shimmura S, Ishida S, Tsubota K.
  • Journal Title: Mol Vis Volume: 15 Pages: 2751-2761
  • URL: http://www.molvis.org/molvis/v15/a290
  • Peer Reviewed
• [Journal Article] Elevation of surfactant protein D, a pulmonary disease biomarker, in the sera of uveitis patients with sarcoidosis (2010)
  • Author(s): Kitaichi N, Kitamura M, Namba K, Ishida S, Ohno S.
  • Journal Title: Jpn J Ophthalmol Volume: 54 Issue: 1 Pages: 81-84
  • DOI: 10.1007/s10384-009-0756-6
  • NAID: 10027203580
  • Peer Reviewed
• [Journal Article] Merkel cell carcinoma of the conjunctiva (2010)
  • Author(s): Kase S, Ishijima K, Ishida S, Rao NA.
  • Journal Title: Ophthalmology Volume: 117 Pages: 637-637
  • URL: http://dx.doi.org/10.1016/j.ophtha.2009.10.011
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-2 expression in human idiopathic epiretinal membrane (2010)
  • Author(s): Kase S, Saito W, Ohno S, Ishida S.
  • Journal Title: Retina Volume: 30 Issue: 5 Pages: 719-723
  • DOI: 10.1097/iae.0b013e3181c59698
  • Peer Reviewed
• [Journal Article] Amelioration of experimental autoimmune uveoretinitis with nuclear factor-{ kappa} B inhibitor dehydroxy methyl epoxyquinomicin in mice (2010)
  • Author(s): Iwata D, Kitaichi N, Ebihara A, Iwabuchi K, Yoshida K, Namba K, Ozaki M, Ohno S, Umezawa K, Yamashita K, Todo S, Ishida S, Onoe K.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 51 Issue: 4 Pages: 2077-2084
  • DOI: 10.1167/iovs.09-4030
  • Peer Reviewed
• [Journal Article] Prevention of experimental autoimmune uveoretinitis by blockade of Osteopontin with small interfering RNA (2010)
  • Author(s): Iwata D, Kitamura M, Kitaichi N, Saito Y, Kon S, Namba K, Morimoto J, Ebihara A, Kitamei, H, Yoshida K, Ishida S, Ohno S, Uede T, Onoe K, Iwabuchi K.
  • Journal Title: Exp Eye Res Volume: 90 Pages: 41-48
  • NAID: 120001821843
  • URL: http://dx.doi.org/10.1016/j.exer.2009.09.008
  • Peer Reviewed
• [Journal Article] Molecular epidemiology of adenoviral keratoconjunctivitis in Saudi Arabia. (2010)
  • Author(s): Tabbara KF, Omar N, Hammouda E, Akanuma M, Ohguchi T, Ariga T, Tagawa Y, Kitaichi N, Ishida S, Aoki K, Ishiko H, Ohno S
  • Journal Title: Mol Vis Volume: 16 Pages: 2132-2136
  • Peer Reviewed
• [Journal Article] Combined vitreous and cataract surgeries in highly hyperopic eye. (2010)
  • Author(s): Inoue M, Shinoda K, Matsuda-Yamamitsu T, Sano RY,Ishida S
  • Journal Title: Clin Ophthalmol Volume: 4 Pages: 1003-1005
  • NAID: 120005372302
  • Peer Reviewed
• [Journal Article] Eicosapentaenoic acid suppresses ocular inflammation in endotoxin-induced uveitis. (2010)
  • Author(s): Suzuki M, Noda K, Kubota S, Hirasawa M, Ozawa Y, Tsubota K, Mizuki N, Ishida S
  • Journal Title: Mol Vis Volume: 16 Pages: 1382-1388
  • NAID: 120002386831
  • Peer Reviewed
• [Journal Article] Calcium channel blocker nilvadipine, but not diltiazem, inhibits ocular inflammation in endotoxin-induced uveitis. (2010)
  • Author(s): Ishida S, Koto T, Nagai N, Oike Y
  • Journal Title: Jpn J Ophthalmol Volume: 54 Pages: 594-601
  • NAID: 10027666392
  • Peer Reviewed
• [Journal Article] Resveratrol prevents light-induced retinal degeneration via suppressing, activator protein-1 activation. (2010)
  • Author(s): Kubota S, Kurihara T, Ebinua M, Kubota M, Yuki K, Sasaki M, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K
  • Journal Title: Am J Pathol Volume: 177 Pages: 1725-1731
  • Peer Reviewed
• [Journal Article] Von Hippel-Lindau protein regulates transition from fetal to adult circulatory system in retina. (2010)
  • Author(s): Kurihara T, Kubota Y, Ozawa Y Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, Suda T, Okano H
  • Journal Title: Development Volume: 137 Pages: 1563-1571
  • Peer Reviewed
• [Journal Article] Secondary macular hole formation with presumed evulsion of foveal hard exudates in a patient with diabetic retinopathy. (2010)
  • Author(s): Tomita Y, Noda K, Shinoda H, Ozawa Y, Tsubota K, Ishida S
  • Journal Title: Jpn J Ophthalmol Volume: 54 Pages: 366-368
  • NAID: 10027204741
  • Peer Reviewed
• [Journal Article] Neurodegenerative influence of oxidative stressin the retina of diabetic mice. (2010)
  • Author(s): Sasaki M, Ozawa Y, Kurihara T, Kubota S,, Yuki K, Noda K, Kobayashi S, Ishida S, Tsubota K
  • Journal Title: Diabetologia Volume: 53 Pages: 971-979
  • Peer Reviewed
• [Journal Article] Retinal phototoxicity in a novel murine model of intraocular lens implantation. (2010)
  • Author(s): Kurihara T, Omoto M, Noda K, Ebinuma M, Kubota S, Koizumi H, Yoshida, S, Ozawa Y, Shimmura S, Ishida S, Tsubota K
  • Journal Title: Mol Vis Volume: 15 Pages: 2751-2761
  • Peer Reviewed
• [Journal Article] Elevation of surfactant protein D, a pulmonary disease biomarker, in the sera of uveitis patients with sarcoidosis. (2010)
  • Author(s): Kitaichi N, Kitamura M, Namba K, Ishida S, Ohno S
  • Journal Title: Jpn J Ophthalmol Volume: 54 Pages: 81-84
  • NAID: 10027203580
  • Peer Reviewed
• [Journal Article] Merkel cell carcinoma of the conjunctiva. (2010)
  • Author(s): Kase S, Ishijima K, Ishida S, Rao NA
  • Journal Title: Ophthalmology Volume: 117 Pages: 637-637
  • Peer Reviewed
• [Journal Article] Cyclooxygenase-2 expression in human idiopathic epiretinal membrane. (2010)
  • Author(s): Kase S, Saito W, Ohno S, Ishida S
  • Journal Title: Retina Volume: 30 Pages: 719-723
  • Peer Reviewed
• [Journal Article] Amelioration of experimental autoimmune uveoretinitis with nuclear factor-{kappa} B inhibitor dehydroxy methyl epoxyquinomicin in mice. (2010)
  • Author(s): Iwata D, Kitaichi N, Ebihara A, Iwabuchi K, Yoshida K, Namba K, Ozaki M, Ohno S, Umezawa K, Yamashita K, Todo S, Ishida S, Onoe K
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 51 Pages: 2077-2084
  • Peer Reviewed
• [Journal Article] Prevention of experimental autoimmune uveoretinitis by blockade of Osteopontin with small interfering RNA. (2010)
  • Author(s): Iwata D, Kitamura M, Kitaichi N, Saito Y, Kon S, Namba K, Morimoto J, Ebihara A, Kitamei H, Yoshida K, Ishida S, Ohno S, Uede T, Onoe K, Iwabuchi K
  • Journal Title: Exp Eye Res Volume: 90 Pages: 41-48
  • NAID: 120001821843
  • Peer Reviewed
• [Journal Article] Proliferative diabetic retinopathy with lymphocyte-rich epiretinal membrane associated with poor visual prognosis (2009)
  • Author(s): Kase S, Saito W, Ohno S, Ishida S.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 50 Issue: 12 Pages: 5909-5912
  • DOI: 10.1167/iovs.09-3767
  • Peer Reviewed
• [Journal Article] Gender-specific associations of vision and hearing impairments with adverse health outcomes in older Japanese : a population-based cohort study (2009)
  • Author(s): Michikawa T, Nishiwaki Y, Kikuchi Y, Nakano M, Iwasawa S, Asakura K, Milojevic A, Mizutari K, Saito H, Ishida S, Okamura T, Takebayashi T.
  • Journal Title: BMC Geriatr Volume: 9 Issue: 1 Pages: 50-50
  • DOI: 10.1186/1471-2318-9-50
• [Journal Article] Mechanism of visual sensations experienced during pars plana vitrectomy under retrobulbar anesthesia (2009)
  • Author(s): Sugisaka E, Shinoda K, Sano RY, Ishida S, Imamura Y, Ozawa Y, Shinoda H, Suzuki K, Tsubota K, Inoue M.
  • Journal Title: Ophthalmologica Volume: 224 Issue: 2 Pages: 103-108
  • DOI: 10.1159/000235858
  • Peer Reviewed
• [Journal Article] Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization (2009)
  • Author(s): Mochimaru H, Takahashi E, Tsukamoto N, Miyazaki J, Yaguchi T, Koto T, Kurihara T, Noda K, Ozawa Y, Ishimoto T, Kawakami Y, Tanihara H, Saya H, Ishida S, Tsubota K.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 50 Issue: 9 Pages: 4410-4415
  • DOI: 10.1167/iovs.08-3044
  • Peer Reviewed
• [Journal Article] (Pro) renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation (2009)
  • Author(s): Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota K, Itoh H, Oike Y, Ishida S.
  • Journal Title: Diabetes Volume: 28 Issue: 7 Pages: 1625-1633
  • DOI: 10.2337/db08-0254
  • Peer Reviewed
• [Journal Article] Prevention of ocular inflammation in endotoxin-induced uveities with resveratrol via inhibiting oxidative damage and nuclear factor-κB activation (2009)
  • Author(s): Kubota S, Kurihara T, Mochimaru H, Satofuka S, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 50 Issue: 7 Pages: 3512-3519
  • DOI: 10.1167/iovs.08-2666
  • Peer Reviewed
• [Journal Article] Suppression of experimental autoimmune uveitis by angiotensin II type 1 receptor blocker telmisartan (2009)
  • Author(s): Okunuki Y, Usui Y, Nagai N, Kezuka T, Ishida S, Takeuchi M, Goto H.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 50 Issue: 5 Pages: 2255-2261
  • DOI: 10.1167/iovs.08-2649
  • Peer Reviewed
• [Journal Article] Neuroprotective effect of an antioxidant, lutein, during retinal inflammation (2009)
  • Author(s): Sasaki M, Ozawa Y, Kurihara T, Noda K, Imamura Y, Kobayashi S, Ishida S, Tsubota K.
  • Journal Title: Invest Ophthalmol Vis Sci Volume: 50 Issue: 3 Pages: 1433-1439
  • DOI: 10.1167/iovs.08-2493
  • Peer Reviewed
• [Journal Article] Serum antioxidants and age-related macular degeneration among older Japanese (2009)
  • Author(s): Michikawa T, Ishida S, Nishiwaki Y, Kikuchi Y, Tsuboi T, Hosoda K, Ishigami A, Iwasawa S, Nakano M, Takebayashi T.
  • Journal Title: Asia Pac J Clin Nutr Volume: 18 Pages: 1-7
  • URL: http://search.proquest.com/docview/213843983?accountid=16200
  • Peer Reviewed
• [Journal Article] Retinal phototoxicity in a novel murine model of intraocular lens implantation. (2009)
  • Author(s): Kurihara T, Omoto M, Noda K, Ebinuma M, Kubota S, Koizumi H, Yoshida S, Ozawa Y, Shimmura S, Ishida S, Tsubota K
  • Journal Title: Mol Vis 15 Pages: 2751-2761
  • Peer Reviewed
• [Journal Article] Proliferative diabetic retinopathy with lymphocyte-rich epiretinal membrane associated with poor visual prognosis. (2009)
  • Author(s): Kase S, Saito W, Ohno S, Ishida S
  • Journal Title: Invest Ophthalmol Vis Sci 50 Pages: 5909-5912
  • Peer Reviewed
• [Journal Article] Gender-specific associations of vision and hearing impairments with adverse health outcomes in older Japanese : a population-based cohort study. (2009)
  • Author(s): Michikawa T, Nishiwaki Y, Kikuchi Y, Nakano M, Iwasawa S, Asakura K, Milojevic A, Mizutari K, Saito H, Ishida S, Okamura T, Takebayashi T.
  • Journal Title: BMC Geriatr 9 Pages: 50-50
  • Peer Reviewed
• [Journal Article] Mechanism of visual sensations experienced during pars plana vitrectomy under retrobulbar anesthesia. (2009)
  • Author(s): Sugisaka E, Shinoda K, Sano R Y, Ishida S, Imamura Y, Ozawa Y, Shinoda H, Suzuki K, Tsubota K, Inoue M.
  • Journal Title: Ophthalmologica 224 Pages: 103-108
  • Peer Reviewed
• [Journal Article] Involvement of hyaluronan and its receptor CD44 with choroidal neovascularization. (2009)
  • Author(s): Mochimaru H, Takahashi E, Tsukamoto N, Miyazaki J, Yaguchi T, Koto T, Kurihara T, Noda K, Ozawa Y, Ishimoto T, Kawakami Y, Tanihara H, Saya H, Ishida S, Tsubota K.
  • Journal Title: Invest Ophthalmol Vis Sci 50 Pages: 4410-4415
  • Peer Reviewed
• [Journal Article] (Pro)renin receptor-mediated signal transduction and tissue renin-angiotensin system contribute to diabetes-induced retinal inflammation. (2009)
  • Author(s): Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Tsubota K, Itoh H, Oike Y, Ishida S.
  • Journal Title: Diabetes 58 Pages: 1625-1633
  • Peer Reviewed
• [Journal Article] Prevention of ocular inflammation in endotoxin-induced uveities with resveratrol via inhibiting oxidative damage and nuclear factor κB activation (2009)
  • Author(s): Kubota S, Kurihara T, Mochimaru H, Satofuka S, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K.
  • Journal Title: Invest Ophthalmol Vis Sci 50 Pages: 3512-3519
  • Peer Reviewed
• [Journal Article] Angiotensin II type 1 receptor blocker telmisartan suppresses experimental autoimmune uveitis. (2009)
  • Author(s): Okunuki Y, Usui Y, Nagai N, Kezuka T, Ishida S, Takeuchi M, Goto H.
  • Journal Title: Invest Ophthalmol Vis Sci 50 Pages: 2255-2261
  • Peer Reviewed
• [Journal Article] Neuroprotective effect of an antioxidant, lutein, during retinal inflammation. (2009)
  • Author(s): Sasaki M, Ozawa Y, Kurihara T, Noda K, Imamura Y, Kobayashi S, Ishida S, Tsubota K
  • Journal Title: Invest Ophthalmol Vis Sci 50 Pages: 1433-1439
  • Peer Reviewed
• [Journal Article] Serum antioxidants and age-related macular degeneration among older Japanese. (2009)
  • Author(s): Michikawa T, Ishida S, Nishiwaki Y, Kikuchi Y, Tsuboi T, Hosoda K, Ishigami A, Iwasawa S, Nakano M, Takebayashi T.
  • Journal Title: Asia Pac J Clin Nutr 18 Pages: 1-7
  • Peer Reviewed
• [Presentation] Role of VEGF as a pro-inflammatory cytokine in macular edema in diabetic retinopathy and other inflammatory diseases. Session ; Translational Research in Ocular Inflammation (2011)
  • Author(s): Ishida S
  • Organizer: 11th International Ocular Inflammation Society(IOIS) Congress and International Assembly of Ocular Inflammation Societies
  • Place of Presentation: Goa, India
  • Year and Date: 2011-11-15
• [Presentation] Panel Discussion with Nguyen QD, Kupperman B, Vitale A, Do D, Natarajan S. Optimizing therapy for diabetic retinopathy synthesizing data from the bench and the clinics. Session ; Pathogenesis of Diabetic Retinopathy : Angiogenesis Inflammation, and Beyond (2011)
  • Author(s): Ishida S
  • Organizer: 11th International Ocular Inflammation Society(IOIS) Congress and International Assembly of Ocular Inflammation Societies
  • Place of Presentation: Goa, India
  • Year and Date: 2011-11-15
• [Presentation] Role of VEGF as a pro-inflammatory cytokine in macular edema in diabetic retinopathy and other inflammatory diseases (2011)
  • Author(s): Ishida S
  • Organizer: 11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies
  • Place of Presentation: Goa, India(招待講演)
  • Year and Date: 2011-11-15
• [Presentation] Optimizing therapy for diabetic retinopathy synthesizing data from the bench and the clinics (2011)
  • Author(s): Ishida S
  • Organizer: 11th International Ocular Inflammation Society (IOIS) Congress and International Assembly of Ocular Inflammation Societies
  • Place of Presentation: Goa, India(招待講演)
  • Year and Date: 2011-11-15
• [Presentation] Astaxanthin is anti-inflammatory and anti-angiogenic in preveventing age-related macular degeneration. Luncheon Seminar III (2011)
  • Author(s): Ishida S
  • Organizer: 5th Biennial Meeting of Society for Free Radical Research-Asia(SFRR-Asia)/8th Conference of Asian Society for Mitochondrial Research and Medicine(ASMRM)/11th Conference of Japanese Society of Mitochondrial Research and Medicine(J-mit)
  • Place of Presentation: Kagoshima, Japan
  • Year and Date: 2011-09-02
• [Presentation] Astaxanthin is anti-inflammatory and anti-angiogenic in preveventing age-related macular degeneration (2011)
  • Author(s): Ishida S
  • Organizer: 5th Biennial Meeting of Society for Free Radical Research-Asia (SFRR-Asia)/8th Conference of Asian Society for Mitochondrial Research and Medicine (ASMRM)/11th Conference of Japanese Society of Mitochondrial Research and Medicine (J-mit)
  • Place of Presentation: Kagoshima Citizens' Culture Hall(鹿児島)(招待講演)
  • Year and Date: 2011-09-02
• [Presentation] Astaxanthin increases choroidal blood flow. Special Interest Group ; A Radical Approach to Aging Eye Disease (2011)
  • Author(s): Ishida S
  • Organizer: Association for Research in Vision and Ophthalmology(ARVO)
  • Place of Presentation: Fort Lauderdale, USA
  • Year and Date: 2011-05-02
• [Presentation] Astaxanthin increases choroidal blood flow (2011)
  • Author(s): Ishida S
  • Organizer: Association for Research in Vision and Ophthalmology (ARVO)
  • Place of Presentation: Fort Lauderdale, USA(招待講演)
  • Year and Date: 2011-05-02
• [Presentation] 眼組織レニン-アンジオテンシン系の成立.イブニングセミナー (2010)
  • Author(s): 石田晋
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 神戸ポートピアホテル、神戸
  • Year and Date: 2010-11-11
• [Presentation] 眼組織レニン・アンジオテンシン系の成立 (2010)
  • Author(s): 石田晋
  • Organizer: 第64回日本臨床眼科学会
  • Place of Presentation: 神戸ポートピアホテル(神戸市) 招待講演
  • Year and Date: 2010-11-11
• [Presentation] 糖尿病網膜症におけるレニン-アンジオテンシン系の役割.シンポジウム「糖尿病網膜症治療の進歩」 (2010)
  • Author(s): 石田晋
  • Organizer: 第25回日本糖尿病合併症学会
  • Place of Presentation: びわ湖ホール・ピアザ淡海(大津市)
  • Year and Date: 2010-10-22
• [Presentation] 糖尿病網膜症におけるレニン・アンジオテンシン系の役割 (2010)
  • Author(s): 石田晋
  • Organizer: 第25回日本糖尿病合併症学会
  • Place of Presentation: びわ湖ホール・ピアザ淡海(大津市) 招待講演
  • Year and Date: 2010-10-22
• [Presentation] レニン-アンジオテンシン系をターゲットとした糖尿病網膜症の新しい治療戦略.シンポジウム「これからの眼科における新しい治療薬」 (2010)
  • Author(s): 石田晋
  • Organizer: 第30回日本眼薬理学会
  • Place of Presentation: 東京コンファレンスセンター、東京
  • Year and Date: 2010-10-02
• [Presentation] レニン・アンジオテンシン系をターゲットとした糖尿病網膜症の新しい治療戦略 (2010)
  • Author(s): 石田晋
  • Organizer: 第30回日本眼薬理学会
  • Place of Presentation: 東京コンフォレンスセンター(東京都) 招待講演
  • Year and Date: 2010-10-02
• [Presentation] Renin-angiotensin system and diabetic retinopathy (2010)
  • Author(s): Ishida S
  • Organizer: The 25th APAO(Asia-Pacific Academy of Ophthalmology)
  • Place of Presentation: Beijing, China
  • Year and Date: 2010-09-17
• [Presentation] Renin-angiotensin system and diabetic retinopathy. (2010)
  • Author(s): Ishida S
  • Organizer: The 25th APAO (Asia-Pacific Academy of Ophthal mology)
  • Place of Presentation: China NationalConvention center (Beijing, China) 招待講演
  • Year and Date: 2010-09-17
• [Presentation] 抗VEGF薬の薬剤特性から考えた使い分け.サブスペシャリティサンデー「網膜硝子体疾患の新しい診断と治療」 (2010)
  • Author(s): 石田晋
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2010-04-18
• [Presentation] 抗VEGF薬の薬剤特性から考えた使い分け (2010)
  • Author(s): 石田晋
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋市) 招待講演
  • Year and Date: 2010-04-18
• [Presentation] 抗VEGF療法におけるアイソフォーム選択性の理論.ランチョンセミナー「抗VEGF薬の選択:理論と実際」 (2010)
  • Author(s): 石田晋
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2010-04-17
• [Presentation] 抗VEGF療法におけるアイソフォーム選択性の理論 (2010)
  • Author(s): 石田晋
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋市) 招待講演
  • Year and Date: 2010-04-17
• [Presentation] Molecular mechanisms underlying neuronal dysfunction in diabetic retinopathy (2010)
  • Author(s): Ishida S
  • Organizer: The Association for Research in Vision and Ophthalmology(ARVO)/Japanese Ophthalmological Society(JOS) Symposium
  • Place of Presentation: Nagoya Congress Center, Nagoya, Japan
  • Year and Date: 2010-04-15
• [Presentation] 受容体随伴プロレニン系と脈絡膜血管新生.シンポジウム「加齢黄斑変性の病態解明」 (2010)
  • Author(s): 石田晋
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場、名古屋
  • Year and Date: 2010-04-15
• [Presentation] Molecular mechanisms underlying neuronal dysfunction in diabetic retinopathy. (2010)
  • Author(s): Ishida S
  • Organizer: The Association for Research in Vision and Ophthalmology (ARVO)/Japanese Ophthalmological Society (JOS) Symposium
  • Place of Presentation: 名古屋国際会議場(名古屋市) 招待講演
  • Year and Date: 2010-04-15
• [Presentation] 受容体随伴プロレニン系と脈絡膜血管新生 (2010)
  • Author(s): 石田晋
  • Organizer: 第114回日本眼科学会総会
  • Place of Presentation: 名古屋国際会議場(名古屋市) 招待講演
  • Year and Date: 2010-04-15
• [Presentation] Receptor-associated prorenin system contributes to diabetes-induced retinal inflammation (2009)
  • Author(s): Ishida S, Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Oike Y, Itoh H, Tsubota
  • Organizer: The 4^<th> Congress of the Asia-Pacific Vitreo-Retinal Society
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2009-11-12
• [Presentation] ヒアルロン酸およびヒアルロン酸受容体CD44の脈絡膜新生血管における関与 (2009)
  • Author(s): 持丸博史、高橋枝里、厚東隆志、野田航介、小沢洋子、谷原秀信、佐谷秀行、石田晋、坪田一男
  • Organizer: 第43回眼炎症学会
  • Place of Presentation: 大阪国際会議場、大阪
  • Year and Date: 2009-07-10
• [Presentation] ルテインによるマウス網膜炎症モデルにおける網膜神経保護効果の解析 (2009)
  • Author(s): 佐々木真理子、小沢洋子、栗原俊英、野田航介、石田晋、坪田一男
  • Organizer: 第51回老年医学会
  • Place of Presentation: パシフィコ横浜、横浜
  • Year and Date: 2009-06-18
• [Presentation] 加齢黄斑変性の分子病態 (2009)
  • Author(s): 石田晋
  • Organizer: 第9回抗加齢医学会
  • Place of Presentation: ホテル日航東京、東京
  • Year and Date: 2009-05-29
• [Presentation] 加齢黄斑変性の分子病態 (2009)
  • Author(s): 石田晋
  • Organizer: 第9回日本抗加齢医学会
  • Place of Presentation: ホテル日航東京(東京都)
  • Year and Date: 2009-05-29
• [Presentation] 抗加齢物質レスベラトロールによる糖尿病網膜症の病態改善 (2009)
  • Author(s): 久保田俊介、石田晋、坪田一男
  • Organizer: 第9回抗加齢医学会
  • Place of Presentation: ホテル日航東京、東京
  • Year and Date: 2009-05-28
• [Presentation] 糖尿病網膜症とreceptor-associated prorenin system(RAPS) (2009)
  • Author(s): 石田晋、里深信吾、伊藤裕、市原淳弘
  • Organizer: 第82回内分泌学会
  • Place of Presentation: 群馬県民会館、前橋
  • Year and Date: 2009-04-23
• [Presentation] 糖尿病網膜症における薬物療法の現状と今後の展望.シンポジウム「テーラーメイド薬物療法の実際と可能性」 (2009)
  • Author(s): 石田晋
  • Organizer: 第113回日本眼科学会
  • Place of Presentation: 東京国際フォーラム、東京
  • Year and Date: 2009-04-17
• [Presentation] 糖尿病網膜症における薬物療法の現状と今後の展望 (2009)
  • Author(s): 石田晋
  • Organizer: 第113回日本眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2009-04-17
• [Presentation] ルテインによるマウス網膜炎症モデルにおける網膜神経保護効果の解析 (2009)
  • Author(s): 小沢洋子、佐々木真理子、栗原俊英、野田航介、石田晋、坪田一男
  • Organizer: 第113回日本眼科学会
  • Place of Presentation: 東京国際フォーラム、東京
  • Year and Date: 2009-04-16
• [Presentation] 抗酸化物質レスベラトロールの糖尿病網膜症への影響 (2009)
  • Author(s): 久保田俊介、栗原俊英、野田航介、小沢洋子、石田晋、坪田一男
  • Organizer: 第113回日本眼科学会
  • Place of Presentation: 東京国際フォーラム、東京
  • Year and Date: 2009-04-16
• [Presentation] ヒアルロン酸およびヒアルロン酸受容体CD44の脈絡膜新生血管における関与 (2009)
  • Author(s): 持丸博史、高橋枝里、厚東隆志、野田航介、小沢洋子、谷原秀信、佐谷秀行、石田晋、坪田一男
  • Organizer: 第113回日本眼科学会
  • Place of Presentation: 東京国際フォーラム、東京
  • Year and Date: 2009-04-16
• [Presentation] 脈絡膜血管新生における炎症機序と病態抑制.シンポジウム「抗血管新生治療の新戦略血管細胞生物学からのアプローチ」 (2009)
  • Author(s): 石田晋
  • Organizer: 第113回日本眼科学会
  • Place of Presentation: 東京国際フォーラム、東京
  • Year and Date: 2009-04-16
• [Presentation] 脈絡膜血管新生における炎症機序と病態抑制 (2009)
  • Author(s): 石田晋
  • Organizer: 第113回日本眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
  • Year and Date: 2009-04-16
• [Presentation] Resveratrol suppresses ocular inflammation in endotoxin-induced uveitis (2009)
  • Author(s): Kubota S, Kurihara T, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K
  • Organizer: The 9^<th> World Congress on Inflammation
  • Place of Presentation: Keio Plaza Hotel, Tokyo, Japan
• [Presentation] Receptor-associated prorenin system contributes to diabetes-induced retinal inflammation (2009)
  • Author(s): Ishida S, Satofuka S, Ichihara A, Nagai N, Noda K, Ozawa Y, Fukamizu A, Oike Y, Itoh H, Tsubota K.
  • Organizer: The 4^<th> Congress of the Asia-Pacific Vitreo-Retinal Society
  • Place of Presentation: Taipei Grand Hotel (Taipei, Taiwan)
• [Presentation] Resveratrol suppresses ocular inflammation in endotoxin-induced uveitis (2009)
  • Author(s): Kubota S, Kurihara T, Noda K, Ozawa Y, Oike Y, Ishida S, Tsubota K.
  • Organizer: The 9^<th> World Congress on Inflammation
  • Place of Presentation: Keio Plaza Hotel (Tokyo, Japan)
• [Presentation] ヒアルロン酸およびヒアルロン酸受容体CD44の脈絡膜新生血管における関与 (2009)
  • Author(s): 持丸博史、高橋枝里、厚東隆志、野田航介、小沢洋子、谷原秀信、佐谷秀行、石田晋、坪田一男
  • Organizer: 第43回 日本眼炎症学会
  • Place of Presentation: グランキューブ大阪(大阪市)
• [Presentation] 抗加齢物質レスベラトロールによる糖尿病網膜症の病態改善 (2009)
  • Author(s): 久保田俊介、石田晋、坪田一男
  • Organizer: 第51回 日本老年医学会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] ルテインによるマウス網膜炎症モデルにおける網膜神経保護効果の解析 (2009)
  • Author(s): 佐々木真理子、小沢洋子、栗原俊英、野田航介、石田晋、坪田一男
  • Organizer: 第51回 日本老年医学会
  • Place of Presentation: パシフィコ横浜(横浜市)
• [Presentation] 抗加齢物質レスベラトロールによる糖尿病網膜症の病態改善 (2009)
  • Author(s): 久保田俊介、石田晋、坪田一男
  • Organizer: 第9回 日本抗加齢医学会
  • Place of Presentation: ホテル日航東京(東京都)
• [Presentation] 糖尿病網膜症とreceptor-associated prorenin system(RAPS) (2009)
  • Author(s): 石田晋、里深信吾、伊藤裕、市原淳弘
  • Organizer: 第82回 日本内分泌学会
  • Place of Presentation: 群馬県民会館(前橋市)
• [Presentation] ルテインによるマウス網膜炎症モデルにおける網膜神経保護効果の解析 (2009)
  • Author(s): 小沢洋子、佐々木真理子、栗原俊英、野田航介、石田晋、坪田一男
  • Organizer: 第113回 日本眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
• [Presentation] 抗酸化物質レスベラトロールの糖尿病網膜症への影響 (2009)
  • Author(s): 久保田俊介、栗原俊英、野田航介、小沢洋子、石田晋、坪田一男
  • Organizer: 第113回 日本眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)
• [Presentation] ヒアルロン酸およびヒアルロン酸受容体CD44の脈絡膜新生血管における関与 (2009)
  • Author(s): 持丸博史、高橋枝里、厚東隆志、野田航介、小沢洋子、谷原秀信、佐谷秀行、石田晋、坪田一男
  • Organizer: 第113回 日本眼科学会
  • Place of Presentation: 東京国際フォーラム(東京都)