| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Research Abstract |
Using a novel murine intraocular lens(IOL) implantation model, we studied the protective effects of colored-IOLs against light-induced retinal photo toxicity. Extra-capsular crystalline lens extraction and IOL implantation were performed in BALB/c mice by a technique similar to human cataract surgery. In contrast to the clear IOL-implanted animals, the yellow IOL-implanted animals had significantly reduced numbers of apoptotic cells and retained thickness of the outer retina, induced by light exposure. Electroretinography showed that yellow IOL implantation prevented a decrease of amplitude in both the a-wave and b-wave compared with clear IOL implantation. We demonstrated the protective effects of colored-IOL against retinal phototoxicity after cataract surgery.
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