Role of Epithelial Mesenchymal Transition on the Pathogenesis of Dry Eye Disease in SOD1 Knock Out Mice

• Project/Area Number: 21592245
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Ophthalmology
• Research Institution: Keio University
• Principal Investigator: NEGISHI Kazuno 慶應義塾大学, 医学部, 准教授 (10228281)
• Co-Investigator(Renkei-kenkyūsha): MURAT Dogru 慶應義塾大学, 医学部, 特任准教授 (60385284)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: ドライアイ / 老化 / ストレス / 酸化ストレス / 涙腺 / 上皮間葉移行

Research Abstract

In the Cu, Zn-superoxide dismutase knock out mice(Sod1-/-mice), decreased tear secretion and ocular surface abnormalities were observed. Moreover, prominent fibrosis, inflammation and increased odidative stress marker staining were found in Sod1-/-mice. The current study revealed that the epithelial-mesenchymal transition could be involved in the histological changes in Sod1-/-mice.

Research Products

• [Journal Article] Age-Related Dysfunction of the Lacrimal Gland and Oxidative Stress : Evidence from the Cu, Zn-Superoxide Dismutase-1(Sod1) Knockout Mice (2012)
  • Author(s): Kojima T, Wakamatsu TH, Dogru M, Ogawa Y, Igarashi A, Ibrahim OM, Inaba T, Shimizu T, Noda S, Obata H, Nakamura S, Wakamatsu A, Shirasawa T, Shimazaki J, Negishi K, Tsubota K
  • Journal Title: Am J Pathol Volume: 180(5) Pages: 1879-96
  • Peer Reviewed
• [Journal Article] Age-Related Dysfunction of the Lacrimal Gland and Oxidative Stress : Evidence from the Cu,Zn-Superoxide Dismutase-1 (Sod1) Knockout Mice (2012)
  • Author(s): Kojima T, Wakamatsu TH, Dogru M, Ogawa Y, Igarashi A, Ibrahim OM, Inaba T, Shimizu T, Noda S, Obata H, Nakamura S, Wakamatsu A, Shirasawa T, Shimazaki J, Negishi K, Tsubota K
  • Journal Title: American Journal of Pathology Volume: (印刷中)
  • Peer Reviewed