| Project/Area Number |
21592250
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
|
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| Research Institution | Matsumoto Dental University |
|---|
Principal Investigator |
OTA Koichi 松本歯科大学, 歯学部, 教授 (70262730)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KIKUCHI Takanobu 信州大学, ヒト環境科学研究支援センター, 教授 (50177797)
SUZUKI Satoru 信州大学, 医学(系)・研究科(研究院), 准教授 (30222061)
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| Co-Investigator(Renkei-kenkyūsha) |
IMAI Hiroki 信州大学, 医学部, 助教 (50568409)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
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| Keywords | 眼細胞生物学 / 眼内炎症 / クリスタリンミュー / エンドトキシン誘発ぶどう膜炎 / 実験的自己免疫性ぶどう膜網膜炎 / レーザー誘発脈絡膜新生血管 / 虹彩・毛様体 / 網膜 / EIU / EAU / 加齢黄斑変性 |
|---|
| Research Abstract |
Three types of murin intraocular inflammation model ; endotoxin-induced uveitis, experimental autoimmune uveoretinitis, and laser-induced choroidal neovascularization was established. The inflammation was mildly reduced in CRYM knock-out mice in all models. The CRYM may be associated with macrophages at second peak rather than neutrophils at first peak in anterior chamber of the eyes with EIU.
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