Pathophysiological analysis and development of therapeutic strategy for refractory corneal and external eye diseases
| Project/Area Number |
21592258
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Tottori University |
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Principal Investigator |
MIYAZAKI Dai 鳥取大学, 医学部附属病院, 講師 (30346358)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Yoshitsugu 鳥取大学, 医学部, 教授 (10213183)
BABA Takashi 鳥取大学, 医学部附属病院, 講師 (40304216)
IKEDA Yoshifumi 鳥取大学, 医学部, 助教 (10444639)
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| Project Period (FY) |
2009 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2011: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 眼免疫学 / アレルギー性結膜炎 / 加齢黄斑変性症 / 角膜内皮 / 眼炎症 / 角膜 / ヘルペス |
|---|
| Research Abstract |
To understand molecular pathology of ocular surface or corneal diseases, contribution of inflammatory or regenerative signals were integrally analyzed. Application of network model-based approach utilizing transcriptome or proteome of diseased tissues or models revealed intricate interactions of innate and acquired immune system in disease processes. The insight on integral regulatory pathways or contributing factors was further utilized to understand age related ocular diseases. Present findings may become basis to develop novel or more efficacious therapeutic strategy
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Blood Level of Tacrolimus in Patients with Severe Allergic Conjunctivitis Treated by 0.1% Tacrolimus Ophthalmic Suspension2012
Author(s)
Ebihara Y, Ohashi Y, Fujishima Y, Fukushima A, Nakagawa Y, Namba K, Okamoto S, Shoji J, Takamura E, Uchio, E, Miyazaki D
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Journal Title
Allergology International
Volume: 61
Issue: 2
Pages: 275-282
DOI
NAID
ISSN
1323-8930, 1440-1592
Related Report
Peer Reviewed
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[Journal Article] Multivariate analysis of inflammatory cytokines in eyes with branch retinal vein occlusion : Relationships to bevacizumab treatment2011
Author(s)
Kaneda S, Miyazaki D, Sasaki S, Yakura K, Terasaka Y, Miyake K, Ikeda Y, Funakoshi T, Baba T, Yamasaki A, & Inoue Y
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Journal Title
Invest Ophthalmol Vis Sci
Volume: 52
Issue: 6
Pages: 2982-2988
DOI
Related Report
Peer Reviewed
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