| Project/Area Number |
21592262
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Gifu Pharmaceutical University |
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Principal Investigator |
HARA Hideaki 岐阜薬科大学, 薬学部, 教授 (20381717)
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| Co-Investigator(Renkei-kenkyūsha) |
SHIMAZAWA Masamitsu 岐阜薬科大学, 薬学部, 准教授 (80381721)
ARAIE Makoto 東京大学, 医学部付属病院眼科, 教授 (00092122)
WATANABE Yasuyoshi 大阪市立大学, 大学院・医学研究科・システム神経科学, 教授 (40144399)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 眼科学 / 神経科学 / 脳・神経 / 眼科 / 緑内障 / 眼圧 / サル / PET |
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| Research Abstract |
We examined lateral geniculate nucleus(LGN) degeneration secondary to experimental hypertensive glaucoma as an indicator for glaucoma in ocular hypertensive monkeys using positron emission tomography(PET), and validated glial activation by morphological and immunohistochemical examinations. Furthermore, we investigated whether endoplasmic reticulum(ER) stress was involved in the pathophysiological mechanisms underlying neuronal death of the LGN after intraocular pressure(IOP) elevation. In the present study, we showed that ER stress may play a pivotal role in neuronal death of the LGN after IOP elevation, that glial activation occurs in the LGN, and that the LGN degeneration could be detected by a PET imaging after unilateral ocular hypertension. Therefore, activated glial markers such as PBR in the LGN may be useful in noninvasive molecular imaging for diagnosis of glaucoma.
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