Effect of infliximab on gene expression profiling in Behcet's disease using microarray analysis
| Project/Area Number |
21592263
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Kyorin University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KEINO Hiroshi 杏林大学, 医学部, 准教授 (90328211)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 生物学的製剤 / ぶどう膜炎 / ベーチェット病 / インフリシマブ / 難治性ぶどう膜炎 / ぶどう膜網膜炎 / 抗TNF-alpha抗体 / マイクロアレイ / 抗TNF-a抗体 |
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| Research Abstract |
In this study, we investigated the effect of infliximab on gene expression patterns in peripheral blood mononuclear cells of Behcet's disease patients(4 cases) before and after initiation of infliximab treatment. Microarray analysis showed that 8 genes were down-regulated and 1 gene was up-regulated in all patients. Quantitative PCR analysis demonstrated that gene expression of CLEC4E, ets2, and TLR2 was down-regulated in all patients. Thus, several up-regulated or down-regulated genes identified in this study may be candidates for further studies in delineating the molecular mechanism of infliximab for the treatment of Behcet's disease with refractory uveoretinitis.
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Report
(4 results)
Research Products
(87 results)
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[Journal Article] Frequency of distinguishing clinical features in Vogt-Koyanagi-Harada disease2010
Author(s)
Rao NA, Gupta A, Dustin L, Chee SP, Okada AA, Khairallah M, Bodaghi B, Lehoang P, Accorinti M, Mochizuki M, Prabriputaloong T
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Journal Title
Ophthalmology
Volume: 117
Pages: 591-599
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