| Project/Area Number |
21592268
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Ophthalmology
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| Research Institution | Osaka Medical College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKU Hidehiro 大阪医科大学, 医学部, 准教授 (90177163)
SUGIYAMA Tetsuya 大阪医科大学, 医学部, 講師 (20298764)
ISHIZAKI Eisuke 大阪医科大学, 医学部, 助教 (70530434)
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| Co-Investigator(Renkei-kenkyūsha) |
TAKAI Shinji 大阪医科大学, 医学部, 准教授 (80288703)
HAYASHI Tetsuya 大阪医科大学, 医学部, 准教授 (30257852)
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| Research Collaborator |
NAKAIZUMI Atsuko 大阪医科大学, 医学部, 大学院生
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 眼免疫学 / 糖尿病網膜症 / 自己免疫 / 抗II型コラーゲン抗体 / 抗IV型コラーゲン抗体 / 硝子体手術 / 低酸素負 / 抗GBM抗体 / 糖尿病黄斑浮腫 / 低酸素負荷マウス |
|---|
| Research Abstract |
We investigated autoimmune reaction for vitreous typeIIcollagen in the pathogenesis of diabetic retinopathy. We compared the levels of anti-type II collagen(II-C) IgG antibody in vitreous fluid and serum in 17 patients with diabetic retinopathy(DR) and 15 patients with non-inflammatory eye diseases, using an enzyme-linked immunosorbent assay(ELISA). In patients with diabetic retinopathy, serum levels of anti-II-C IgG antibody were significantly higher than those of control subjects(p<0.05). We conclude that serum levels of anti-II-C antibody might reflect the progression of DR. and measuring anti-II-C antibody levels is a useful means to assess prognosis of diabetic microangiopathy.
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