Research on the development of the new medical treatment and its clinical use in adenoviral ocular infection
Project/Area Number |
21592269
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
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Research Institution | Fukuoka University |
Principal Investigator |
UCHIO Eiichi 福岡大学, 医学部, 教授 (70232840)
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Project Period (FY) |
2009 – 2011
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Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
Keywords | アデノウイルス / 抗ウイルス薬 / 逆転写酵素阻害薬 / 抗HIV薬 / レセプター阻害薬 / 急性結膜炎 / 自然免疫 / 抗菌ペプチド / インターフェロン-ベータ / インターフェロン-ガンマ / ザルシタビン / スタブジン |
Research Abstract |
We evaluated anti-adenoviral activity of candidate agents in vitro. Among interferons, both interferon beta and gamma showed significant antiviral effect on adenovirus. LL-37, an antimicrobial peptide, also had antiadenoviral activity on all types except for type 4.These results suggest that these agents might be used safely for treatment of human adenoviral conjunctivitis in the near future.
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Report
(4 results)
Research Products
(77 results)
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[Journal Article] アデノウイルス結膜炎院内感染対策ガイドライン2009
Author(s)
塩田洋, 大野重昭, 青木功喜, 安積淳, 石子博昭, 井上幸次, 薄井紀夫, 内尾英一, 金子久俊, 熊倉重人, 田川義継, 谷藤泰寛, 中川尚, 日隈陸太郎, 山崎修道, 横井則彦
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Journal Title
日本眼科学会雑誌
Volume: 113
Pages: 25-46
NAID
Related Report
Peer Reviewed
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[Journal Article] A large prospective observational study of novel cyclosporine 0.1% aqueous ophthalmic solution in the treatment of severe allergic conjunctivitis2009
Author(s)
Ebihara N, Ohashi Y, Uchio E, Okamoto S, Kumagai N, Shoji J, Takamura E, Nakagawa Y, Nanba K, Fukushima A, Fujishima H
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Journal Title
J Ocul Pharmacol Ther 25
Pages: 365-371
Related Report
Peer Reviewed
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[Journal Article] アデノウイルス結膜炎院内感染対策ガイドライン2009
Author(s)
塩田洋, 大野重昭, 青木功喜, 安積淳, 石子博昭, 井上幸次, 薄井紀夫, 内尾英一, 金子久俊, 熊倉重人, 田川義継, 谷藤泰寛, 中川尚, 日隈陸太郎, 山崎修道, 横井則彦
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Journal Title
日本眼科学会雑誌 113
Pages: 25-46
NAID
Related Report
Peer Reviewed
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[Presentation] 結膜診療のコツ2011
Author(s)
内尾英一
Organizer
第115回日本眼科学会総会
Place of Presentation
東京国際フォーラム
Year and Date
2011-05-16
Related Report
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[Presentation] 治療と感染予防2010
Author(s)
内尾英一
Organizer
第11回日本アデノウイルス研究会
Place of Presentation
東京都, 京王プラザホテル
Year and Date
2010-07-10
Related Report
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[Presentation] 治療と感染予防2010
Author(s)
内尾英一
Organizer
第11回日本アデノウイルス研究会
Place of Presentation
東京都
Year and Date
2010-07-08
Related Report
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