Modulation of host environment in retinal cell transplantation using retinal degeneration models.
Project/Area Number |
21592270
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Ophthalmology
|
Research Institution | The Institute of Physical and Chemical Research |
Principal Investigator |
MANDAI Michiko 独立行政法人理化学研究所, 網膜再生医療研究チーム, 研究員 (80263086)
|
Co-Investigator(Renkei-kenkyūsha) |
TAKAHASHI Masayo 独立行政法人理化学研究所, 網膜再生医療研究チーム, チームリーダー (80252443)
HOMMA Kohei 独立行政法人理化学研究所, 網膜再生医療研究チーム, 研究員 (80462729)
|
Project Period (FY) |
2009 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | 眼科学 / 再生医学 / 網膜変性 / 網膜移植 / 視細胞移植 / グリオーシス |
Research Abstract |
Retinal degeneration models as were studied as a host for the acceptability of transplanted cells. Graft cells survived best when transplanted within a period of after the massive cell death and before the host gliosis progresses. In this time window, anti-inflammatory reagent and a synaptogenic factor enhanced graft cell(neonatal retinal cells) survival, and anti-gliotic reagent enhanced graft cell survival in later transplantation. We also prepared ES/iPS derived retinal cells for future practical transplantation experiments.
|
Report
(4 results)
Research Products
(37 results)
-
-
-
-
-
-
-
-
-
-
[Presentation] 視細胞移植と網膜機能2011
Author(s)
金子潤、万代道子、本間耕平、高橋政代
Organizer
第15回視覚科学フォーラム
Place of Presentation
大阪大学,大阪
Year and Date
2011-08-29
Related Report
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] 網膜の再生医療2009
Author(s)
万代道子
Organizer
ヒト細胞学会
Place of Presentation
東京都、東京慈恵会医科大学
Year and Date
2009-08-22
Related Report
-
-
-
-
[Book] 医学のあゆみ2011
Author(s)
万代道子、高橋政代
Total Pages
4
Publisher
多能性幹細胞を用いた加齢黄斑変性の細胞移植治療
Related Report
-
-
-
-