• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Molecular biological analysis by organ culture and application to fetal treatment using mice model with anorectal malformation

Research Project

Project/Area Number 21592276
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionShiga University of Medical Science

Principal Investigator

KUBOTA Yoshihiro  滋賀医科大学, 医学部, 助教 (30305601)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords直腸肛門奇形 / 器官培養 / 胎仔治療
Research Abstract

A single high dose of etretinate, a long-acting synthetic retinoid, induces ARMs in mice. Abnormal intrinsic innervation of mice embryos with anorectal malformations at later developmental stages was eliminated by molecular biological methods. Organ culture was quite difficult, but it will be possible to succeed it. It is necessary to continue to study it.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (5 results)

All 2012 2010 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results) Remarks (1 results)

  • [Journal Article] Abnormal development of intrinsic innervation in murine embryos with anorectal malformations2012

    • Author(s)
      Kubota Y, Cho H, Umeda T, Abe H, Kurumi Y, Tani T.
    • Journal Title

      Pediatric Surgery International

      Volume: 28(3) Pages: 295-298

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Abnormal development of intrinsic innervation in murine embryos with anorectal malformations2012

    • Author(s)
      Yoshihiro Kubota, Hirotomi Cho, Tomoko Umeda, Hajime Abe, Yoshimasa Kurumi, Toru Tani
    • Journal Title

      Pediatric Surgery International

      Volume: 28 Pages: 295-298

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Abnormal development of intrinsic innervation of murine embryos with anorectal malformation2010

    • Author(s)
      Kubota Y.
    • Organizer
      Pacific Association of Pediatric Surgeons
    • Place of Presentation
      Kobe, Japan
    • Year and Date
      2010-05-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Abnormal development of intrinsic innervation of marine embryos with anorectal malformation2010

    • Author(s)
      Yoshihiro Kubota
    • Organizer
      Pacific Association of Pediatric Surgeons
    • Place of Presentation
      ポートピアホテル、神戸
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://shiga-med.ac.jp/~hqsurge1/hqsurge1/staff.html

    • Related Report
      2011 Final Research Report

URL: 

Published: 2009-04-01   Modified: 2016-04-21  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi