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Basic studies regarding the usefulness of STEP procedure in short bowel syndrome

Research Project

Project/Area Number 21592277
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatric surgery
Research InstitutionUniversity of Tsukuba (2011)
Fukuoka University (2009-2010)

Principal Investigator

MASUMOTO Kouji  筑波大学, 医学医療系, 教授 (20343329)

Co-Investigator(Kenkyū-buntansha) TAGUCHI Tomoaki  九州大学, 医学研究院, 教授 (20197247)
NAKAMURA Masatoshi  福岡大学, 医学部, 助教 (10580285)
永田 公二  九州大学, 大学病院, 医員 (20419568)
江角 元史郎  九州大学, 大学病院, 医員 (30452759)
手柴 理沙  九州大学, 大学病院, 医員 (60452760)
甲斐 裕樹  福岡大学, 医学部, 助教 (60380432)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords短腸症候群 / 小児 / 腸管延長術 / 有用性 / 腸閉鎖症 / 腸閉鎖
Research Abstract

The rat neonatal short bowel syndrome (SBS) model related to intestinal atresia was made at first. STEP (Serial Transverse Enteroplasty) procedure was performed for the SBS rat model one month after short bowel was made. The chronological changes of intramural components in dilated intestine after STEP procedure was investigated and compared using immunohistological staings between SBS-STEP models and SBS models. The results showed the abnormal change of intramural components (ganglion cells, nerve fibers, smooth muscle cells, and pacemaker cells) relatively improved in SBS-STEP models, compared to those in SBS models. Therefore, based on our studies, the early STEP procedure, performing before the proximal dilatation will be extremely, might induce the early improvement of the intramural abnormal changes in SBS.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (20 results)

All 2011 2010 2009

All Journal Article (14 results) (of which Peer Reviewed: 12 results) Presentation (6 results)

  • [Journal Article] A case of cystic biliary atresia with an antenatally detected cyst : the possibility of changing from a correctable type witha cystic lesion (I cyst) to an uncorrectable one (IIId)2011

    • Author(s)
      Masumoto K, et al
    • Journal Title

      Pediatr Surg Int

      Volume: 27 Pages: 99-102

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Successful treatment of an infected wound in infants by a combination of negative pressure wound therapy and arginine supplementation2011

    • Author(s)
      Masumoto K, et al
    • Journal Title

      Nutrition

      Volume: 27 Pages: 1141-1145

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Usefulness of exchanging a tunneled central venous catheter using a subcutaneous fibrous sheath2011

    • Author(s)
      Masumoto K, et al
    • Journal Title

      Nutrition

      Volume: 27 Pages: 526-529

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A case of cystic biliary atresia with an antenatally detected cyst : the possibility of changing from a correctable type with a cystic lesion (I cyst) to an uncorrectable one (IIId)2011

    • Author(s)
      Masumoto K, et al
    • Journal Title

      Pediatr Surg Int

      Volume: 27 Issue: 1 Pages: 99-102

    • DOI

      10.1007/s00383-010-2715-1

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ヒルシュスプルング病類縁疾患患児の在宅におけるQOL向上への栄養管理の工夫2010

    • Author(s)
      増本幸二, 他
    • Journal Title

      小児外科

      Volume: 42 Pages: 420-425

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] 超短腸症候群に合併したミルクアレルギー2010

    • Author(s)
      増本幸二, 他
    • Journal Title

      小児外科

      Volume: 42 Pages: 946-951

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Journal Article] Umbilical crease incision for duodenal atresia achieves excellent cosmetic results2010

    • Author(s)
      Takahashi Y, Masumoto K, et al
    • Journal Title

      Pediatr Surg Int

      Volume: 26 Pages: 963-966

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Umbilical crease incision for duodenal atresia achieves excellent cosmeticresults2010

    • Author(s)
      Takahashi Y, Masumoto K, et al.
    • Journal Title

      Pediatr Surg Int

      Volume: 26 Pages: 963-966

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement in the outcome of patients with antenatally diagnosed congenital diaphragmatic hernia using gentle ventilation and circulatory stabilization2009

    • Author(s)
      Masumoto K, Teshiba R, Esumi G, et al
    • Journal Title

      Pediatr Surg Int

      Volume: 25(6) Pages: 487-492

    • NAID

      10029305718

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Duodenal stenosis resulting from a preduodenal portal vein and an operation for scoliosis2009

    • Author(s)
      Masumoto K, Teshiba R, Esumi G, et al
    • Journal Title

      World J Gastroenterol

      Volume: 15(31) Pages: 3590-3593

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Need for thiamine in the peripheral parenteral nutrition after abdominal surgery in children2009

    • Author(s)
      Masumoto K, Esumi G, Teshiba R, et al
    • Journal Title

      JPEN : J Parent Enteral Nutr

      Volume: 33(4) Pages: 417-422

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Need for thiamine in the peripheral parenteral nutrition after abdominal surgery in children2009

    • Author(s)
      Masumoto K, Esumi G, Teshiba R, et al.
    • Journal Title

      JPEN : J Parent Enteral Nutr 33(4)

      Pages: 417-422

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Duodenal stenosis resulting from a preduodenal portal vein and an operation for scoliosis2009

    • Author(s)
      Masumoto K, Teshiba R, Esumi G, et al.
    • Journal Title

      World J Gastroenterol 15(31)

      Pages: 3590-3593

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Improvement in the outcome of patients with antenatally diagnosed congenital diaphragmatic hernia using gentle ventilation and circulatory stabilization2009

    • Author(s)
      Masumoto K, Teshiba R, Esumi G, et al.
    • Journal Title

      Pediatr Surg Int 25(6)

      Pages: 487-492

    • NAID

      10029305718

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] 小児術後静脈栄養時における微量元素製剤の必要性の検討2011

    • Author(s)
      増本幸二, ほか3名
    • Organizer
      第111 回日本外科学会
    • Place of Presentation
      東京(誌上開催)
    • Related Report
      2011 Final Research Report
  • [Presentation] 小児術後静脈栄養時における微量元素製剤の必要性の検討2011

    • Author(s)
      増本幸二, ほか3名
    • Organizer
      第111回日本外科学会
    • Place of Presentation
      東京(誌上)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 残存小腸10cm以下の超短腸症候群患児に対するSTEP (serial transverse enteroplasty) 手術の有用性2010

    • Author(s)
      増本幸二, 他3名
    • Organizer
      第47回日本外科代謝栄養学会
    • Place of Presentation
      横浜
    • Year and Date
      2010-07-08
    • Related Report
      2011 Final Research Report
  • [Presentation] 残存小腸10cm以下の超短腸症候群患児に対するSTEP(serial transverse enter oplasty)手術の有用性2010

    • Author(s)
      増本幸二, 他3名
    • Organizer
      第47回日本外科代謝栄養学会
    • Place of Presentation
      横浜
    • Year and Date
      2010-07-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 残存小腸10cm以下の超短腸症候群患児に対するSTEP(serial transverse enteroplasty)手術の有用性2009

    • Author(s)
      増本幸二, 他4名
    • Organizer
      第109回日本外科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 残存小腸10cm以下の超短腸症候群患児に対するSTEP(serial transverse enteroplastv)手術の有用性2009

    • Author(s)
      増本幸二, 他4名
    • Organizer
      第109回日本外科学会
    • Place of Presentation
      福岡
    • Year and Date
      2009-04-04
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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