| Project/Area Number |
21592280
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pediatric surgery
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
YAMADA Takatsugu 奈良県立医科大学, 医学部, 助教 (20316061)
UEDA Tsuyoshi 奈良県立医科大学, 医学部附属病院, 研究員 (40526810)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 先天性消化器疾患学 / 再生医学 / 幹細胞 / 細胞・臓器移植 / 多能性幹細胞 / ES細胞 / iPS細胞 / 腸管分化誘導 / 神経堤幹細胞 / 細胞シート / ヒルシュスプルング病 |
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| Research Abstract |
For a new treatment strategy for Hirschsprung's disease, we tried to performe the differentiation from induced pluripotent stem cells to enteric nervous system using the three-dimensional culture. We demonstrate that mouse iPS cells have the ability to organize a gut-like organ with motor function in vitro by three-dementional culture. A gut-like organ was composed of all the enteric components of three germ layers. When this study aims for treatment of Hirschsprung's disease, it was very important discovery to organization of functional gut including the nervous system from iPS cells which have a disease-specific characteristic.
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