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Basic research about the development of the allogeneic reconstituted skin equivalent which induces local immunotolerance

Research Project

Project/Area Number 21592290
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Plastic surgery
Research InstitutionSapporo Medical University

Principal Investigator

MATSUMOTO Yoshitaka  札幌医科大学, 医学部, 助教 (70452977)

Co-Investigator(Kenkyū-buntansha) YOTSUYANAGI Takatoshi  札幌医科大学, 医学部, 教授 (70250595)
江副 京理  札幌医科大学, 医学部, 講師 (20274938)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords組織培養 / 移植学 / 同種皮膚移植 / 免疫寛容 / サイトカイン / 再構築皮膚 / 3次元培養 / 組織工学 / 不死化株 / HPV E7
Research Abstract

Basic research was performed with inbred rat strain to develope the allogeneic reconstituted skin equivalent inducing local immunotolerance.
Keratinocyte and fibroblast was derived from rat skin, and the keratinocyte was immortalized(AK-E7). The reconstituted skin equivalent, using AK-E7 with fibroblast, showed nearly normal histologic epidermal structure. The cultured supernatant of the fibroblast transfected with IL-10 cDNA(AFB-IL10) inhibited mixed lymphocyte reaction. As the reconstituted skin equivalent using AK-E7 and AFB-IL10 was grafted into autograft model, its partial take was recognized histologically.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (1 results)

All 2011

All Presentation (1 results)

  • [Presentation] 局所免疫寛容を誘導する同種再構築皮膚の開発を目指して2011

    • Author(s)
      松本佳隆
    • Organizer
      第7回札弘形成外科研究会
    • Place of Presentation
      札幌
    • Year and Date
      2011-10-22
    • Related Report
      2011 Annual Research Report 2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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