| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Using a three-dimensional skin culture model and a wound healing model, we tried to review difference in epithelium formation and re-epithelizaion process on skin equivalent model consist of fibroblasts which were obtained from normal skin and chronic ulcer. Fibroblasts obtained from chronic ulcer showed poor proliferative capacity, and both epithelium formation and re-epithelizaion process were insufficient. We used a substitute system that we use multiple passaged fibroblasts or hydrocortisone containing culture medium. In a skin equivalent model, the contraction process and the hardness were inhibited. And in a skin culture model and wound healing model, epithelium formation and re-epithelizaion process were restrained.
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