| Project/Area Number |
21592296
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Plastic surgery
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| Research Institution | Tokyo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
IMAI Ryutaro 東京医科大学, 形成外科学講座, 講師 (80384949)
KOMIYA Takako 東京医科大学, 形成外科学講座, 助教 (00385105)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 創傷治癒学 / 肥厚性瘢痕 / キマーゼ / TGFββ / クラウン系 / ミニブタ / キマーゼ阻害薬 / TGFβ / 動物モデル / ヒドロキシプロリン / キマーゼ活 / 瘢痕動物モデル |
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| Research Abstract |
Hypertrophic scaring is a devastating problem after trauma and surgery. Mary researches have been extensively achieved, but the pathophysiology is still unknown and no therapeutic agent breakthrough. One of this reason is the lack of good animal model for hypertrophic scaring. Female Red Droc Pig(FRDP) is a novel animal model but the pig become very big and body weight becomes over 200Kg and handling of the pig is very difficult and need large space for experiments.
The clawn miniature swine which we used, is much easier to use in the study and confirmed that it's scar is fully compatible to human hypertrophic scar.
Using this model, we found that the tissue chymase activity was deeply related to the thickness of the hypertrophic scar. We speculate that chymase participate in the pathophysiology of hypertrophic scar and anti-chymase agents is potentially effective therapeutic agent for hypertrophic scarring.
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