| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Research Abstract |
To elucidate the pathophysiology of organ dysfunction associated with sepsis, we have analyzed cytotoxicity induced by proinflammatory cytokines in various cultured cell lines.
A mixture of proinflammatory cytokines exerted synergistic cytotoxic effects and this cytotoxicity was mediated at least partially by the caspase-dependent apoptotic signaling pathway.
The profile of cytotoxicity differed according to cell types, in terms of nitric oxide or MAP kinase dependency.
Antiinflammatory agents or antioxidants showed prominent cytoprotective effects against the cytotoxicity induced by proinflammatory cytokines.
Cell death other than apoptosis was implied in the underlying mechanism of the cytotoxicity induced by proinflammatory cytokines.
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