| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Research Abstract |
We studied basic experiments for the optimal LPS dose that induced septic state of mice. It was difficult to decide the optimal LPS dose that induced septic state. Then, we tried studying for the LPS dose using anti-TNF drug. Interestingly, the mice treated with only LPS were survived, and the mice treated with LPS and anti-TNF drug were dead. Probably, it means that inflammatory cytokines are necessary for the bio response at the inflammatory state. The further study is necessary. On the other hand, we studied gut function associated with liver failure at high glucose state induced by sepsis. At high glucose state of diabetes mellitus, Cajal cells from bone marrow were decreased in small intestine. We reported that.
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