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Identification of urinary biomarkers to predict onset of acute kidney injury with proteomic analysis

Research Project

Project/Area Number 21592310
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionYamaguchi University

Principal Investigator

KASAOKA Shunji  山口大学, 大学院・医学系研究科, 准教授 (90243667)

Co-Investigator(Kenkyū-buntansha) MAEKAWA Tsuyoshi  山口大学, 大学院・医学系研究科, 教授 (60034972)
IZUMI Tomonori  山口大学, 大学院・医学系研究科, 准教授 (00261694)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords急性腎障害 / 尿中バイオマーカー / プロテオーム解析 / 尿プロテオーム解析
Research Abstract

We investigated the usefulness of urinary biomarker for early diagnosis of acute kidney injury(AKI). Our study suggested that urinary NGAL might be more useful for early diagnosis of AKI than urinary L-FABP. In addition, 368 kinds of proteins by proteomic analysis of urine have been detected, and it is to be expected to establish a new biomarker.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (7 results)

All 2012 2011 2010 2009

All Presentation (7 results)

  • [Presentation] Urinary biomarkers for the early detection of acute kidney injury2012

    • Author(s)
      笠岡俊志
    • Organizer
      第41回米国集中治療医学会
    • Place of Presentation
      ヒューストン(米国)
    • Year and Date
      2012-02-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Urinary biomarkers for the early detection of acute kidney injury2012

    • Author(s)
      笠岡俊志
    • Organizer
      第41回米国集中治療医学会(Critical Care Congress)
    • Place of Presentation
      ヒューストン(米国)
    • Year and Date
      2012-02-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 重症救急患者における急性腎障害の早期発見に対する尿中バイオマーカーの有用性2011

    • Author(s)
      笠岡俊志
    • Organizer
      第14回日本臨床救急医学会総会・学術集会
    • Place of Presentation
      札幌(札幌コンベンションセンター)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] 重症救急患者における急性腎障害の早期発見に対する尿中バイオマーカーの有用性2011

    • Author(s)
      笠岡俊志
    • Organizer
      第14回日本臨床救急医学会総会・学術集会
    • Place of Presentation
      札幌コンベンションセンター(札幌)
    • Year and Date
      2011-06-04
    • Related Report
      2011 Annual Research Report
  • [Presentation] 重症救急患者における急性腎障害の早期発見に対する尿中バイオマーカーの有用性2010

    • Author(s)
      笠岡俊志
    • Organizer
      第2回Japan AKI Summit
    • Place of Presentation
      東京(品川インターシティ)
    • Year and Date
      2010-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 重症救急患者における急性腎障害の早期発見に対する尿中バイオマーカーの有用性2010

    • Author(s)
      笠岡俊志
    • Organizer
      第2回 Japan AKI Summit
    • Place of Presentation
      東京
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 横紋筋融解症による急性腎障害に対するカルペリチドの効果と尿中L型脂肪酸結合蛋白への影響2009

    • Author(s)
      笠岡俊志
    • Organizer
      第1回Japan AKI Summit
    • Place of Presentation
      東京
    • Year and Date
      2009-11-08
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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