| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
Hyperthermia is considered an important condition that may contribute to multiple organ failure(MOF) associated with endothelial cell damage. We demonstrated that endothelial cells may exhibit a temperature-dependent mechanism of cytokine interleukin(IL)-8releases and the suppression of cytokine protein production after transient hyperthermia stimuli even though an increased level of IL-8mRNA was observed. As there is a long-term effect of IL-6or8modulation after transient hyperthermia with increasing in mRNA expression after incubating endothelial cells under high-temperature stimuli, then the process might subsequently lead to neutrophil infiltration into the injured tissue, which in turn could worsen the outcome by enhancing secondary injury processes.
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