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急性肺障害における血管内皮前駆細胞の動態解析:自家移植による再生治療の試み

Research Project

Project/Area Number 21592318
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionFujita Health University (2010-2011)
Aichi Medical University (2009)

Principal Investigator

TAKEYAMA Naoshi  藤田保健衛生大学, 医学部, 教授 (00155053)

Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords集中治療 / ALI/ARDS / 急性肺障害 / 内皮前駆細胞 / 自家移植 / VEGF / CD133 / CD31 / CD34 / syto16 / FACS / 血管内皮前駆細胞
Research Abstract

Objective : Impaired fibrinolysis is associated with a higher incidence of both multiple organ dysfunction and mortality in the intensive care unit(ICU). Plasminogen activator inhibitor(PAI)-1 is the chief inhibitor of fibrinolysis. We investigated the influence of the 4G/5G polymorphism(rs1799768) of the PAI-1 gene on the plasma PAI-1 level and the outcome of critically ill patients. Methods : In 41 consecutive patients admitted to the ICU, PAI-1 gene polymorphism was assessed, plasma PAI-1 and arterial lactate concentrations were measured and clinical severity scores were recorded. Results : Homozygotes for the 4G allele had higher plasma levels of PAI-1 antigen. The mean 8 SD PAI-1 antigen level was 193.318 167.93 ng/ml for the 4G/4G genotype, 100.67 8 114.16 ng/ml for the 4G/5G genotype and 0.43 8 0.53 ng/ml for the 5G/5G genotype. There was a significant correlation between plasma PAI-1 and arterial lactate concentrations, as well as between PAI-1 and severity scores. The mortality rate was 63, 33 and 0% for patients with the 4G/4G, 4G/5G and 5G/5G genotypes, respectively. Conclusions : These results demonstrate that the 4G/5G polymorphism of the PAI-1 gene affects the plasma PAI-1 concentration, which could impair fibrinolysis and cause organ failure, and thus the presence of the 4G allele increases the risk of death.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (4 results)

All 2012

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (2 results)

  • [Journal Article] 4G/5G polymorphism of the plasminogen activator-1 gene is associated with multiple organ dysfunction in critically ill patients2012

    • Author(s)
      Huq MA, Takeyama N, Harada M, Miki Y, Takeuchi A, Inoue S, Nakagawa T, Kanou H, Hirakawa A, Noguchi H
    • Journal Title

      Acta Haematologica

      Volume: 127 Pages: 72-80

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 4G/5G polymorphism of the plasminogen activator inhibitor-1 gene is associated with multiple organ dysfunction in critically ill patients2012

    • Author(s)
      Huq MA, Takeyama N, Harada M, Miki Y
    • Journal Title

      Acta Haematologica

      Volume: 127 Pages: 72-80

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 4G/5G polymorphism of the PAI-1 gene is associated with multiple organ dysfunction in ICU patients2012

    • Author(s)
      Huq A, Takeyama N, Hirakawa A
    • Organizer
      The 12^<th> Joint Scientific Congress of JAICM and KSCCM
    • Place of Presentation
      千葉
    • Year and Date
      2012-02-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 4G/5G polymorphism of the PAI-1 gene is associated with multiple organ dysfunction in ICU patients2012

    • Author(s)
      Huq MA, Takeyama N, Hirakawa A, et al
    • Organizer
      The 12th joint scientific congress of KSCCM and JSICM
    • Place of Presentation
      Chiba
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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