| Project/Area Number |
21592323
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
|
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| Research Institution | Osaka University |
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Principal Investigator |
OGAWA Yuzo 大阪大学, 大学院・歯学研究科, 准教授 (10135725)
|
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| Co-Investigator(Kenkyū-buntansha) |
SATO Sunao 大阪大学, 大学院・歯学研究科, 講師 (70335660)
MURAKAMI Syumei 大阪大学, 大学院・歯学研究科, 准教授 (00263301)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 唾液腺 / 幹細胞 / マウス / 免疫組織化学 / bromodeoxyuridine / CD117 / 細胞培養 / BrdU |
|---|
| Research Abstract |
Tissue stem cells, which retain bromodeoxyuridine(BrdU) label, have been localized to the intercalated and excretory ducts of rat submandibular glands. BrdU label-retaining cells were found in the intercalated duct of mouse submandibular glands. The intercalated duct cells expressed CD29, CD49f and CD117, suggesting they are the stem cells of mouse salivary gland. CD117-positive cells isolated from mouse submandibular glands, however, failed to form floating spheres, a characteristic feature of tissue stem cells.
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