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A study of abnormal orofacial pain and activation of glial cells in the central nervous system.

Research Project

Project/Area Number 21592324
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionOkayama University

Principal Investigator

TERAYAMA Ryuji  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60333689)

Co-Investigator(Renkei-kenkyūsha) SUGIMOTO Tomosada  岡山大学, 大学院・医歯薬学総合研究科, 教授 (50135729)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
KeywordsMAP Kinase / 神経損傷 / 痛覚異常 / ミクログリア / アストログリア / 三叉神経知覚核群 / MAP kinase / MAP Pkinase
Research Abstract

In this study, involvement of activation of glial cells in the central nervous system in abnormal orofacial pain and changes in neuronal excitability following peripheral nerve injury were investigated. I observed differential activation of microglia, astroglia, and several MAP kinases, considered to be related to glial activation, in the brainstem. Differential changes in neuronal excitability in the brainstem were also observed after peripheral nerve injury.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (24 results)

All 2012 2011 2010 2009

All Journal Article (9 results) (of which Peer Reviewed: 8 results) Presentation (15 results)

  • [Journal Article] Fos protein-like immunoreactive neurons induced by electrical stimulation in the trigeminal sensory nuclear complex of rats with chronically injured peripheral nerve2012

    • Author(s)
      Fujisawa N, Terayama R, Yamaguchi D, Omura S, Yamashiro T, Sugimoto T
    • Journal Title

      Exp Brain Res

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fos protein-like immunoreactive neurons induced by electrical stimulation in the trigeminal sensory nuclear complex of rats with chronically injured peripheral nerve2012

    • Author(s)
      Fujisawa N, Terayama R, Yamaguchi D, Omura S, Yamashiro T, Sugimoto T
    • Journal Title

      Experimental Brain Research

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 三叉神経一次知覚ニューロンの中枢内投射と痛覚受容機構2011

    • Author(s)
      寺山隆司、杉本朋貞
    • Journal Title

      脳21

      Volume: Vol.14、No.4

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Differential activation of mitogen-activated protein kinases and glial cells in the trigeminal sensory nuclear complex following lingual nerve injury2011

    • Author(s)
      Terayama R, Fujisawa N, Yamaguchi D, Omura S, Ichikawa H, Sugimoto T
    • Journal Title

      Neuroscience Res

      Volume: 69(2) Pages: 100-110

    • NAID

      10028190466

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Persistent hypoglossal artery with hypoplasia of the vertebral and posterior communicating arteries2011

    • Author(s)
      Terayama R, Fujisawa N, Yamaguchi D, Omura S, Ichikawa H, Sugimoto T
    • Journal Title

      Anat Sci Int

      Volume: 86(1) Pages: 58-61

    • NAID

      10031162236

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Differential activation of mitogen-activated protein kinases and glial cells in the trigeminal sensory nuclear complex following lingual nerve injury.2011

    • Author(s)
      Terayama R, Fujisawa N, Yamaguchi D, Omura S, Ichikawa H, Sugimoto T.
    • Journal Title

      Neuroscience Research

      Volume: 69 Pages: 100-110

    • NAID

      10028190466

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tunicamycin-induced cell death in the trigeminal ganglion is suppressed by nerve growth factor in the mouse embryo2010

    • Author(s)
      Ichikawa H, Zhao BR, Kano M, Shimizu Y, Suzuki T, Terayama R, Matsuo S, Sugimoto T
    • Journal Title

      Cell Mol Neurobiol

      Volume: 30(3) Pages: 461-467

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peptide 19 in the rat superior cervical ganglion2009

    • Author(s)
      Ichikawa H, Terayama R, Yamaai T, Sugimoto T
    • Journal Title

      Neuroscience

      Volume: 161(1) Pages: 86-94

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Brn-3a deficiency transiently increases expression of calbindin D-28 k and calretinin in the trigeminal ganglion during embryonic development2009

    • Author(s)
      Ichikawa H, Terayama R, Yamaai T, Jacobowitz DM, Qiu F, Xiang M, Sugimoto T
    • Journal Title

      Cell Mol Neurobiol

      Volume: 29(5) Pages: 691-698

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Presentation] 三叉神経一次知覚ニューロンの中枢内投射と痛覚受容機構2012

    • Author(s)
      寺山隆司
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨県甲府市・山梨大学甲府キャンパス
    • Year and Date
      2012-03-27
    • Related Report
      2011 Final Research Report
  • [Presentation] 三叉神経一次知覚ニューロンの中枢内投射と痛覚受容機構2012

    • Author(s)
      寺山隆司
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      山梨県甲府市・山梨大学甲府キャンパス(招待講演)
    • Year and Date
      2012-03-27
    • Related Report
      2011 Annual Research Report
  • [Presentation] 舌神経損傷後の三叉神経知覚核群におけるMAP kinaseおよびグリア細胞の活性化2011

    • Author(s)
      寺山隆司
    • Organizer
      日本解剖学会第66回中国・四国支部学術集会
    • Place of Presentation
      徳島県徳島市・徳島大学蔵本キャンパス
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 末梢神経損傷後の脊髄後角ニューロンの過剰興奮に対するアデノシンA1受容体アゴニスト2-chloro-N(6)-cyclopentyladenosine(CCPA)の効果2011

    • Author(s)
      山口大輔
    • Organizer
      日本解剖学会第66回中国・四国支部学術集会
    • Place of Presentation
      徳島県徳島市・徳島大学蔵本キャンパス
    • Year and Date
      2011-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 末梢神経損傷後の脊髄後角ニューロンの過剰興奮に対するアデノシンA1受容体アゴニスト2-chloro-N(6)-cyclopentyladenosine (CCPA)の効果2011

    • Author(s)
      山口大輔
    • Organizer
      日本解剖学会第66回中国・四国支部学術集会
    • Place of Presentation
      徳島県徳島市・徳島大学蔵本キャンパス
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] Differential activation of mitogen-activated protein kinases and glial cells in the trigeminal sensory nuclear complex following lingual nerve injury2011

    • Author(s)
      寺山隆司
    • Organizer
      第34回日本神経科学大会
    • Place of Presentation
      神奈川県横浜市・パシフィコ横浜
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 末梢神経損傷後の舌神経刺激に対する三叉神経二次知覚ニューロンの応答2011

    • Author(s)
      藤澤直子
    • Organizer
      第88回日本生理学会大会第116回日本解剖学会総会・全国学術集会合同大会
    • Year and Date
      2011-03-30
    • Related Report
      2011 Final Research Report
  • [Presentation] 末梢神経損傷後の舌神経刺激に対する三叉神経二次知覚ニューロンの応答2011

    • Author(s)
      藤澤直子
    • Organizer
      第88回日本生理学会大会 第116回日本解剖学会総会・全国学術集会合同大会
    • Place of Presentation
      誌上開催 Journal of Physiolgical Sciences
    • Year and Date
      2011-03-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] 末梢神経損傷後の三叉神経知覚核群におけるMAP kinaseおよびグリア細胞の活性化2010

    • Author(s)
      寺山隆司
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京都江戸川区・タワーホール船堀
    • Year and Date
      2010-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] 末梢神経損傷後の吻側亜核におけるニューロンの興奮性の変化2010

    • Author(s)
      藤澤直子
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京都江戸川区・タワーホール船堀
    • Year and Date
      2010-09-21
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] 末梢神経損傷後の三叉神経知覚核群における MAP kinase およびグリア細胞の活性化2010

    • Author(s)
      寺山隆司
    • Organizer
      第52回歯科基礎医学会学術大会
    • Place of Presentation
      東京都江戸川区・タワーホール船堀
    • Year and Date
      2010-09-21
    • Related Report
      2010 Annual Research Report
  • [Presentation] 舌神経損傷後の三叉神経知覚核群におけるp38およびERK MAP kinaseの活性化2009

    • Author(s)
      寺山隆司
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      新潟県新潟市・朱鷺メッセ新潟コンベンションセンター
    • Year and Date
      2009-09-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 舌神経損傷後の三叉神経知覚核群におけるニューロンの興奮性の変化2009

    • Author(s)
      藤澤直子
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      新潟県新潟市・朱鷺メッセ新潟コンベンションセンター
    • Year and Date
      2009-09-11
    • Related Report
      2011 Final Research Report
  • [Presentation] 舌神経損傷後の三叉神経知覚核群におけるp38およびERK MAP kinaseの活性化2009

    • Author(s)
      寺山隆司
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      新潟市
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 舌神経損傷後の三叉神経知覚核群におけるニューロンの興奮性の変化2009

    • Author(s)
      藤澤直子
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      新潟市
    • Year and Date
      2009-09-11
    • Related Report
      2009 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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