A study of abnormal orofacial pain and activation of glial cells in the central nervous system.
| Project/Area Number |
21592324
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
TERAYAMA Ryuji 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (60333689)
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| Co-Investigator(Renkei-kenkyūsha) |
SUGIMOTO Tomosada 岡山大学, 大学院・医歯薬学総合研究科, 教授 (50135729)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | MAP Kinase / 神経損傷 / 痛覚異常 / ミクログリア / アストログリア / 三叉神経知覚核群 / MAP kinase / MAP Pkinase |
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| Research Abstract |
In this study, involvement of activation of glial cells in the central nervous system in abnormal orofacial pain and changes in neuronal excitability following peripheral nerve injury were investigated. I observed differential activation of microglia, astroglia, and several MAP kinases, considered to be related to glial activation, in the brainstem. Differential changes in neuronal excitability in the brainstem were also observed after peripheral nerve injury.
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Report
(4 results)
Research Products
(24 results)
