| Project/Area Number |
21592334
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kyushu University |
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Principal Investigator |
KIDO Mizuho 九州大学, 歯学研究院, 准教授 (60253457)
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| Co-Investigator(Renkei-kenkyūsha) |
WANG B 九州大学, 歯学研究院, 特任教授 (20452716)
ZHANG Jq 九州大学, 歯学研究院, 技術専門職員 (80380707)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2009: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 口腔感覚 / 温度受容 / TPPVチャネル / TRPチャネル / センサー / 上皮細胞 / 口腔粘膜 / 温度感覚 / マウス / ラット |
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| Research Abstract |
The oral cavity is covered by oral epithelia Oral epithelia undergo various stimuli such as temperature or mechanical stimuli. Oral epithelia properly sense those stimuli and then discard toxic or harmful substances and ingest materials necessary for our body. Even though a wider range of temperatures stimulates the oral cavity more than other parts of the body, we do not know the mechanisms of the oral thermal sensory system. We hypothesized that oral epithelia have thermal sensory properties and which then adapt to the oral envimnment We found that thermosensitive transient receptor potential(TRP) channels were functionally expressed in oral epithelia It is suggested that proliferation and epithelial cell cell contact were regulated via channel activity.
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