Cancer stem cells of salivary gland tumors : identification and contribution to histological morphogenesis

• Project/Area Number: 21592335
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Morphological basic dentistry
• Research Institution: Nagasaki University
• Principal Investigator: FUJITA Shuichi 長崎大学, 大学院・医歯薬学総合研究科, 准教授 (00181355)
• Co-Investigator(Kenkyū-buntansha): IKEDA Tohru 長崎大学, 大学院・医歯薬学総合研究科, 教授 (00211029) ; SHIBATA Yasuaki 長崎大学, 大学院・医歯薬学総合研究科, 助教 (80253673)
• Co-Investigator(Renkei-kenkyūsha): YAMADA Shin-ichi 長崎大学, 大学病院, 講師 (50380853)
• Project Period (FY): 2009 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000); Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 癌幹細胞 / 唾液腺腫瘍 / 組織構築 / 細胞外基質 / ニッチ / 免疫組織化学 / CD44, CD133 / 睡液腺腫瘍 / 多形腺腫 / 腺様嚢胞癌 / CD133 / CD44 / 腫瘍幹細胞 / 唾液腺

Research Abstract

Cancer stem cells(CSCs) are defined cells within a tumor that possess the capacity to self-renew and to induce the heterogeneous lineages of cancer cells that comprise the tumor. CSCs are related to histogenesis, morphogenesis and prognosis of the tumors. We investigated the relationship with morphogenesis based on the immunohistochemical distribution of CSCs. Salivary gland tumors, especially malignancies showed high density of the CSCs adjacent to the extracellular matrices. The finding suggested that the extracellular matrices control the activity of CSCs. In the morphogenesis of the characteristic salivary gland tumor, CSCs are considered to be activated by the extracellular matrices as a microenvironment(niche).

Research Products

• [Journal Article] Cancer stem-like cells in adenoid cystic carcinoma of salivary glands : relationship with morphogenesis of histological variants (2012)
  • Author(s): Fujita S, Ikeda T.
  • Journal Title: J Oral Pathol Med Volume: 41 Pages: 207-213
  • Peer Reviewed
• [Presentation] 多形腺腫と腺様嚢胞癌での腫瘍幹細胞の分布の相違: CD44による免疫組織化学的解析 (2011)
  • Author(s): 藤田修一、池田通
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-30
• [Presentation] 多形腺腫と腺様嚢胞癌での腫瘍幹細胞の分布の相違:CD44による免疫組織化学的解析 (2011)
  • Author(s): 藤田修一、池田通
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-04-30
• [Presentation] 唾液腺腺様嚢胞癌でのCD133を用いた癌幹細胞の免疫組織化学的解析 (2010)
  • Author(s): 藤田修一、池田通
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 東京
  • Year and Date: 2010-04-28
• [Presentation] 唾液腺腺様嚢胞癌でのCD133を用いた癌幹細胞の免疫組織学的解析 (2010)
  • Author(s): 藤田修一
  • Organizer: 第99回日本病理学会総会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2010-04-28