| Project/Area Number |
21592337
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Kagoshima University |
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Principal Investigator |
SEMBA Ichiro 鹿児島大学, 医歯学総合研究科, 教授 (60145505)
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| Co-Investigator(Kenkyū-buntansha) |
HIRAYAMA Yoshikazu 鹿児島大学, 大学院・医歯学総合研究科, 助教 (50343364)
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| Research Collaborator |
OYAZATO Yoshitaka 鹿児島大学, 大学院・医歯学総合研究科, RA
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 口腔癌前癌病変 / 4NQO誘発ラット舌癌モデル / 遺伝子変異 / 遺伝子発現異常RT-PCR / 免疫組織化学 / 病理組織形態 / DNA損傷修復 / 遺伝子発現異常 / RT-PCR |
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| Research Abstract |
In this study, we successfully established field-cancerization animal model of tongue carcinoma. The model provides well compatibility of macroscopic and microscopic findings and analysis for chronological and site specific changes of the precancerous lesion. In this model, the precancerous lesion shows diffuse epithelial dysplasia and the grade of histological atypia was increased during the carcinogen administration period, although interruption of the administration of the carcinogen brought decrease the atypia but further advanced lesions such as focal protrude lesion and invasive carcinoma.
There is high level expression of genes related with double strands DNA damage repair in the precancerous lesions, and it suggests that different properties from in the invasive carcinoma.
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