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In situ proliferation and differentiation of macrophages in the dental pulp

Research Project

Project/Area Number 21592342
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Morphological basic dentistry
Research InstitutionShowa University

Principal Investigator

NAKAMURA Masanori  昭和大学, 歯学部, 教授 (50180394)

Co-Investigator(Kenkyū-buntansha) NONAKA Naoko  昭和大学, 歯学部, 助教 (20307052)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2009: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords口腔解剖学(含組織学・発生学)マクロファージ / 歯胚 / M-CSF / GM-CSF / 細胞分化 / マクロファージ
Research Abstract

It is well recognized that resident macrophages exist in the dental pulp. However, it is uncertain whether these macrophages proliferate and differentiate in the dental pulp in situ, or whether they constantly migrate from the blood stream into the dental pulp. In this study, we examined and compared the development of dental pulp macrophages in an organ culture system by using in vivo tooth organs to clarify the developmental mechanism of these macrophages. The first mandibular molar tooth organs from the ICR strain mice aged between 16-days of gestation(E16) to 5-days postnatal(5dPN) were used for in vivo experiments. The E16 first mandibular molar tooth organs were cultured for up to 14 days with or without 10% fetal bovine serum. Dental pulp tissues were analyzed with immunohistochemistry to detect the macrophages and with RT-PCR for the detection of factors related to the macrophage development. The growth curves for the in vivo-and in vitro-cultured cells revealed similar numbers of F4/80 positive macrophages in the dental pulp. RT-PCR analysis indicated the constant expression of M-CSF in both in vivo-and in vitro-cultured dental pulp tissues. Anti-M-CSF antibodies significantly inhibited the increase in the number of resident macrophages in the dental pulp. These results suggested that (1) most of the dental pulp macrophages proliferated and differentiated in the dental pulp without a supply of precursor cells from the blood stream, (2) M-CSF might be the candidate molecule for the development of dental pulp macrophages, and (3) serum factors might not directly affect the development of the macrophages.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (65 results)

All 2012 2011 2010 2009 Other

All Journal Article (32 results) (of which Peer Reviewed: 13 results) Presentation (30 results) Book (3 results)

  • [Journal Article] The role of macrophages for the disappearance of Meckel's cartilage during development in mice2011

    • Author(s)
      Tsuzurahara F, Soeta S, Kawawa T, Baba K, Nakamura M
    • Journal Title

      Acta Histochem

      Volume: 113 Pages: 194-200

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Kupffer cells support extramedullary erythropoiesis induced by nitrogen-containing bisphosphonate in splenectomized mice2011

    • Author(s)
      Otsuka H, Yagi H, Endo Y, Nonaka N, Nakamura M
    • Journal Title

      Cell Immunol

      Volume: 271 Pages: 197-204

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Roles of platelets and macrophages in the protective effects of lipopolysaccharide against concanavalin A-induced murine hepatitis2011

    • Author(s)
      Yu Z, Otsuka H, Yamaguchi K, Kuroishi T, Sasano T, Sugawara S, Nakamura M, Endo Y
    • Journal Title

      Biochim Biophys Acta

      Volume: 1812 Pages: 1069-1079

    • Related Report
      2011 Final Research Report
  • [Journal Article] In situ proliferation and differentiation of macrophages in dental pulp2011

    • Author(s)
      Iwasaki K, Otsuka H, Yanagisawa N, Hisamitsu H, Manabe A, Nonaka N, Nakamura M
    • Journal Title

      Cell Tissue Res

      Volume: 346 Pages: 99-109

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Journal Article] Direct Resorption of Calcified Cartilage by Macrophages during Primary Bone Marrow Cavity Formation2010

    • Author(s)
      Murayama T, Endo Y, Kawawa T, Baba K, Nakamura M
    • Journal Title

      Dent Med Res

      Volume: 30 Pages: 1-8

    • NAID

      10026361573

    • Related Report
      2011 Final Research Report
  • [Journal Article] Localization and Phenotype of Resident Macrophages in the Dental Pulp during Rat Mandibular First Molar Development2010

    • Author(s)
      Miyauchi Y, Mayahara M, Sasa R, Inoue M, Nakamura M
    • Journal Title

      Dent Med Res

      Volume: 30 Pages: 15-21

    • NAID

      10026361637

    • Related Report
      2011 Final Research Report
  • [Journal Article] Morphometrical, Histological and Ultrastructural Analyses of Bone Formation and Resorption Induced by Synthetic Octacalcium Phosphate in Mouse Bone Marrow2010

    • Author(s)
      NagaiY, Mayahara M, Suzuki O, Hisamitsu H, Nakamura M
    • Journal Title

      Dent Med Res

      Volume: 30 Pages: 29-35

    • NAID

      10026361695

    • Related Report
      2011 Final Research Report
  • [Journal Article] Direct Bone Destruction by Neutrophils in Collagen-induced Arthritis Treated with Bisphosphonates2010

    • Author(s)
      Nakayama M, Yagi H, Endo Y, Maki K, Nakamura M
    • Journal Title

      Dent Med Res

      Volume: 30 Pages: 211-218

    • NAID

      10027973237

    • Related Report
      2011 Final Research Report
  • [Journal Article] Macrophages Are Key Cells for the Initiation of Meckel's Cartilage Disappearance2010

    • Author(s)
      Tsuzurahara F, Nakamura M
    • Journal Title

      J Oral Biosci

      Volume: 52 Pages: 150-154

    • NAID

      10027105796

    • Related Report
      2011 Final Research Report
  • [Journal Article] Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase A2gamma-deficient mice2010

    • Author(s)
      Yoda E, Hachisu K, Taketomi Y, Yoshida K, Nakamura M, Ikeda K, Taguchi R, Nakatani Y, Kuwata H, Murakami M, Kudo I, Hara S
    • Journal Title

      J Lipid Res

      Volume: 51 Pages: 3003-15

    • Related Report
      2011 Final Research Report
  • [Journal Article] Carbonic anhydrase II regulates differentiation of ameloblasts via intracellular pH-dependent JNK signaling pathway2010

    • Author(s)
      Wang X, Suzawa T, Ohtsuka H, Zhao B, Miyamoto Y, Miyauchi T, Nishimura R, Inoue T, Nakamura M, Baba K, Kamijo R
    • Journal Title

      J Cell Physiol

      Volume: 225 Pages: 709-719

    • Related Report
      2011 Final Research Report
  • [Journal Article] Immunohistochemical comparison of ontogenic development of bone marrow hematopoiesis in two different ossification system2010

    • Author(s)
      Ikeda M, Ohtsuka H, Iwasaki Y, Ikeda-Isogai M, Baba K, Nakamura M
    • Journal Title

      Dent Med Res

      Volume: 30 Pages: 228-236

    • NAID

      10027973313

    • Related Report
      2011 Final Research Report
  • [Journal Article] Direct Resorption of Calcified Cartilage by Macrophages during Primary Bone Marrow Cavity Formation.2010

    • Author(s)
      Murayama T, Endo Y, Kawawa T, Baba K, Nakamura M
    • Journal Title

      Dent Med Res

      Volume: 30 Pages: 1-8

    • NAID

      10026361573

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Localization and Phenotype of Resident Macrophages in the Dental Pulp during Rat Mandibular First Molar Development.2010

    • Author(s)
      Miyauchi Y, Mayahara M, Sasa R, Inoue M, Nakamura M
    • Journal Title

      Dent Med Res

      Volume: 30 Pages: 15-21

    • NAID

      10026361637

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphometrical, Histological and Ultrastructural Analyses of Bone Formation and Resorption Induced by Synthetic Octacalcium Phosphate in Mouse Bone Marrow.2010

    • Author(s)
      Nagai Y, Mayahara M, Suzuki O, Hisamitsu H, Nakamura M
    • Journal Title

      Dent Wed Res

      Volume: 30 Pages: 29-35

    • NAID

      10026361695

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Macrophages Are Key Cells for the Initiation of Meckel's Cartilage Disappearance.2010

    • Author(s)
      Tsuzurahara F, Nakamura M
    • Journal Title

      J Oral Biosci

      Volume: 52 Pages: 150-154

    • NAID

      10027105796

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mitochondrial dysfunction and reduced prostaglandin synthesis in skeletal muscle of Group VIB Ca2+-independent phospholipase.A2gamma-deficient mice.2010

    • Author(s)
      Yoda E, Hachisu K, Taketomi Y, Yoshida K, Nakamura M, Ikeda K, Taguchi R, Nakatani Y, Kuwata H, Murakami M, Kudo I, Hara S
    • Journal Title

      J Lipid Res

      Volume: 51 Pages: 3003-3015

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carbonic anhydrase II regulates differentiation of ameloblasts viaintracellular pH-dependent JNK signaling pathway.2010

    • Author(s)
      Wang X, Suzawa T, Ohtsuka H, Zhao B, Miyamoto Y, Miyauchi T, Nishimura R, Inoue T, Nakamura M, Baba K, Kamijo R
    • Journal Title

      J Cell Physiol

      Volume: 225 Pages: 709-719

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Three-dimensional ultrastructural study of medial and distal fibrous capsules in the human adult temporomandibular joint.2010

    • Author(s)
      Kobayashi H, Segawa K, Nakamura M
    • Journal Title

      Dent Med Res

      Volume: 30 Pages: 109-116

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Regional restriction of lymphoid follicles in the lymph node by the draining lymphatic vessels.2010

    • Author(s)
      Sekine Y, Ohtsuka T, Yanagisawa Y, Sakagami J, Nonaka N, Namakura M
    • Journal Title

      Dent Med Res

      Volume: 30 Pages: 124-128

    • NAID

      10027973045

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Micro CT Analysis on the Correlation of a Cervical Defect and the Reparative Dentin in Human Permanent Teeth.2010

    • Author(s)
      Higashi Shoichi, Mayahara M, Kodaka T, Egawa K, Nakamura M, Inoue M
    • Journal Title

      Dent Med Res

      Volume: 30 Pages: 129-135

    • NAID

      10027973068

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunohistochemical comparison of ontogenic development of bone marrow hematopoiesis in two different ossification system.2010

    • Author(s)
      Ikeda M, Ohtsuka H, Iwasaki Y, Ikeda-Isogai M, Baba K, Nakamura M
    • Journal Title

      Dent Med Res

      Volume: 30 Pages: 228-236

    • NAID

      10027973313

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphometric and functional correlation of human neuronal somata : Pyramidal motor, special sensory and general sensory systems2009

    • Author(s)
      Shibata M, Goto N, Goto J, Nonaka N, Nakamura M.
    • Journal Title

      Okajima Folia Anat Jpn

      Volume: 85 Pages: 115-117

    • NAID

      130004773576

    • Related Report
      2011 Final Research Report
  • [Journal Article] Rejection of intradermally injected syngeneic tumor cells from mice by specific elimination of tumor-associated macrophages with liposome-encapsulated dichloromethylene diphosphonate, followed by induction of CD11b(+)/CCR3(-)/Gr-1(-) cells cytotoxic against the tumor cells2009

    • Author(s)
      Takahashi T, Ibata M, Yu Z, Shikama Y, Endo Y, Miyauchi Y, Nakamura M, Tashiro-Yamaji J, Miura-Takeda S, Shimizu T, Okada M, Ueda K, Kubota T, Yoshida R.
    • Journal Title

      Cancer Immunol Immunother

      Volume: 58 Pages: 2011-2023

    • Related Report
      2011 Final Research Report
  • [Journal Article] Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development2009

    • Author(s)
      Suzuki D, Yamada A, Amano T, Yasuhara R, Kimura A, Sakahara M, Tsumaki N, Takeda S, Tamura M, Nakamura M, Wada N, Nohno T, Shiroishi T, Aiba A, Kamijo R.
    • Journal Title

      Dev Biol

      Volume: 335 Pages: 396-406

    • Related Report
      2011 Final Research Report
  • [Journal Article] Dynamics of platelet mobilization into lungs in response to 5-hydroxytryptamine(serotonin) in mice2009

    • Author(s)
      Yu Z, Ohba M, Nakamura M, Sasano T, Ono M, Sugawara S, Endo Y.
    • Journal Title

      Thrombosis and Haemostasis

      Volume: 102 Pages: 1251-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Bisphosphonate-related osteonecrosis of the jaw around dental implants in the maxilla : report of a case2009

    • Author(s)
      Shirota T, Nakamura A, Matsui Y, Hatori M, Nakamura M, Shintani S
    • Journal Title

      Clin Oral Implants Res

      Volume: 20 Pages: 1402-8

    • Related Report
      2011 Final Research Report
  • [Journal Article] Osteoclast differentiation induced by synthetic octacalcium phosphate through RANKL expression in osteoblasts2009

    • Author(s)
      Takami M, Mochizuki A, Yamada A, Tachi K, Zhao B, Miyamoto Y, Anada T, Honda Y, Inoue T, Nakamura M, Suzuki O, Kamijo R.
    • Journal Title

      Tissue Eng Part A

      Volume: 15 Pages: 3991-4000

    • Related Report
      2011 Final Research Report
  • [Journal Article] Immunological Characterization of Junctional Epithelium : An Immunohistochemical Study2009

    • Author(s)
      Fujioka M, Sasa R, Inoue M, Nakamura M
    • Journal Title

      Dent Med Res

      Volume: 29 Pages: 253-258

    • NAID

      10026361487

    • Related Report
      2011 Final Research Report
  • [Journal Article] Immunological Characterzation of functional Epithelium : An Immunohistochemical Study2009

    • Author(s)
      Fujioka M, Sasa R, Inoue M, Nakamura M
    • Journal Title

      Dental Medicine Research 29

      Pages: 253-258

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bisphosphonate-related osteonecrosis of the jaw around dental implants in the maxilla : report of a case2009

    • Author(s)
      Snirota I, Nakamura A, Matsui Y, Hatori M, Nakamura M, Shintani S
    • Journal Title

      Clin Oral Implants Res 20

      Pages: 1402-1408

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The role of macrophages for the disappearance of Meckel's cartilage during development in mice

    • Author(s)
      Tuzurahara F, Soeta S, Kawawa T, Baba K, Nakamura M
    • Journal Title

      Acta Histochem (in press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] マウス血リンパ節様構造における赤血球造血について2012

    • Author(s)
      大塚裕忠、中村雅典
    • Organizer
      第117回日本解剖学会総会・学術集会
    • Place of Presentation
      甲府
    • Related Report
      2011 Annual Research Report
  • [Presentation] 成体における神経堤由来細胞の分布とそれを用いた骨芽細胞の分化誘導2011

    • Author(s)
      小野美樹, 高見正道, 須澤徹夫, 山田篤, 宮内知彦, 馬場一美, 中村雅典, 槇宏太郎, 上條竜太郎
    • Organizer
      第29回日本骨代謝学会学術集会
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス唾液腺におけるPACAPレセプターの局在とPACAPの唾液分泌への効果2011

    • Author(s)
      野中直子、中村雅典
    • Organizer
      第53回歯科基礎医学会学術大会・総会
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス唾液腺におけるPACAPレセプターおよびVPレセプターの免疫組織化学的局在と唾液分泌への効果2011

    • Author(s)
      野中直子, 中町智哉, 塩田清二, 中村雅典
    • Organizer
      第52回日本組織細胞化学会総会・学術集会
    • Related Report
      2011 Final Research Report
  • [Presentation] 窒素含有ビスホスホネート投与によって誘導された肝臓内造血について2011

    • Author(s)
      大塚裕忠、中村雅典
    • Organizer
      第116回日本解剖学会総会・全国学術集会
    • Related Report
      2011 Final Research Report
  • [Presentation] Immunohistochemical localization of pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptor (PAC-1) in mouse major salivary glands2011

    • Author(s)
      Naoko Nonaka, Tomoya Nakamachi, Seiji Shioda, Masanori Nakamura
    • Organizer
      AAA Annual Meeting at Experimental Biology
    • Place of Presentation
      Washington DC
    • Related Report
      2011 Annual Research Report
  • [Presentation] Immunohistochemical localizations of pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptor (PAC1R) in mouse major salivary glands2011

    • Author(s)
      Naoko Nonaka, Tomoya Nakamachi, Seiji Shioda, Masanori Nakamura
    • Organizer
      第10回日中合同組織細胞化学セミナー
    • Place of Presentation
      北京
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス唾液腺におけるPACAPレセプターおよびVIPレセプターの免疫組織化学的局在と唾液分泌への効果2011

    • Author(s)
      野中直子, 中町智哉, 塩田清二, 中村雅典
    • Organizer
      第52回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      金沢
    • Related Report
      2011 Annual Research Report
  • [Presentation] Induction of hemal nodes like structure in mice2011

    • Author(s)
      Ohtsuka H, Nakamura M
    • Organizer
      第116回日本解剖学会総会・全国学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunohistochemical comparison of the localization of PACAP and its receptor PAC-1 in major salivary glands between young and old mice2011

    • Author(s)
      Naoko Nonaka, Tomoya Nakamachi, Seiji Shioda, Masanori Nakamura
    • Organizer
      第116回日本解剖学会総会・全国学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] Nuclei of the raphe in human2011

    • Author(s)
      Shibata M, Goto N, Goto J, Nonaka N, Nakamura M, Shioda S
    • Organizer
      第116回日本解剖学会総会・全国学術集会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2010 Annual Research Report
  • [Presentation] 顎顔面口腔組織における神経堤由来細胞の分布解析とそれを用いた骨芽細胞様細胞の分化誘導2010

    • Author(s)
      小野美樹, 高見正道, 須澤徹夫, 山田篤, 宮内知彦, 林竜平, 荒田悟, 細野知彦, 馬場一美, 中村雅典, 槇宏太郎, 西田幸二, 大隅典子, 上條竜太郎
    • Organizer
      第47回日本口腔組織培養学会
    • Place of Presentation
      高知大学
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脾臓摘出マウスへの窒素含有ビスホスホネート投与により誘導された髄外造血について2010

    • Author(s)
      大塚裕忠、中村雅典
    • Organizer
      日本解剖学会関東支部会
    • Place of Presentation
      日本獣医生命科学大学
    • Year and Date
      2010-10-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脾臓摘出マウスへの窒素含有ビスホスホネート投与により誘導された髄外造血について2010

    • Author(s)
      大塚裕忠、中村雅典
    • Organizer
      日本獣医学会総会・学術集会
    • Related Report
      2011 Final Research Report
  • [Presentation] III型sPLA2はマスト細胞介在性アナフィラキシーを制御する2010

    • Author(s)
      武富芳隆, 佐藤弘泰, 田中智之, 中村雅典, 上野紀子, 西藤泰昌, 山本圭, 杉本幸彦, 原俊太郎, 村上誠
    • Organizer
      第83回日本生化学会大会・第33回日本分子生物学会年会合同大会
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス唾液腺におけるPACAP、PAC-1レセプターの免疫組織化学的研究2010

    • Author(s)
      野中直子, 中町智哉, 塩田清二, 中村雅典
    • Organizer
      第51回日本組織細胞化学会総会・学術集会
    • Related Report
      2011 Final Research Report
  • [Presentation] 歯髄内常在性マクロファージの増殖・分化機序2010

    • Author(s)
      岩崎之克, 柳澤伸彰, 大塚裕忠, 久光久, 真鍋厚史, 中村雅典
    • Organizer
      第46回口腔組織培養学学術集会
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス唾液腺におけるPACAPとPAC-1受容体の免疫組織学的局在2010

    • Author(s)
      野中直子, 中町智哉, 塩田清二, 中村雅典
    • Organizer
      第115回日本解剖学会総会・全国学術集会
    • Related Report
      2011 Final Research Report
  • [Presentation] 加齢ラットの脛骨及び切歯象牙質のマグネシウム分布2010

    • Author(s)
      佐野恒吉, 中村雅典
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      京王プラザホテル(東京)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 昭和犬学歯学部における解剖学実習の現状2010

    • Author(s)
      江川薫, 中島功, 野中直子, 森陵一, 柳澤伸彰, 中村雅典
    • Organizer
      第52回歯科基礎医学会学術大会・総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2010 Annual Research Report
  • [Presentation] マウス唾液腺におけるPACAP、 PAC-1レセプターの免疫組織化学的研究2010

    • Author(s)
      野中直子, 中町智也, 塩田清二, 中村雅典
    • Organizer
      第51回日本組織細胞化学会総会・学術集会
    • Place of Presentation
      秋葉原コンベンションホール
    • Related Report
      2010 Annual Research Report
  • [Presentation] 骨形成因子(BMP)による骨造成を想定した実験的研究2010

    • Author(s)
      成田憲司, 織田光夫, 馬谷原光織, 中川祥, 久保田耕世, 榊宏剛, 佐藤寿, 小林恒、片岡竜太, 中村雅典, 木村博人
    • Organizer
      第64回日本口腔科学会学術集会
    • Place of Presentation
      札幌プリンスホテル
    • Related Report
      2010 Annual Research Report
  • [Presentation] Immunohistochemical localization of PACAP and PAC-1 receptors in mouse salivary glands.2010

    • Author(s)
      Naoko Nonaka, Tomoya Nakamachi, Seiji Shioda, Masanori Nakamura
    • Organizer
      第10回日本抗加齢医学会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2010 Annual Research Report
  • [Presentation] 脾臓摘出マウスへの窒素含有ビスホスホネート投与により誘導された髄外造血について2010

    • Author(s)
      大塚裕忠、中村雅典
    • Organizer
      第22回日本比較免疫学会学術総会
    • Place of Presentation
      九州大学西新プラザ
    • Related Report
      2010 Annual Research Report
  • [Presentation] Kupffer cells support extramedullary erythropoiesis induced by nitrogen-containing bisphosphonate in splectomized mice2010

    • Author(s)
      Ohtsuka H, Nakamura M
    • Organizer
      14th International Congress of Immunology
    • Place of Presentation
      神戸国際展示場
    • Related Report
      2010 Annual Research Report
  • [Presentation] 低分子量Gタンパク質Raclは四肢骨格形成に必須である2010

    • Author(s)
      鈴木大, 山田篤, 安原理佳, 立川哲彦, 中村雅典, 上條竜太郎
    • Organizer
      第52回歯科基礎医学会学術大会・総会
    • Place of Presentation
      タワーホール船堀(東京)
    • Related Report
      2010 Annual Research Report
  • [Presentation] 歯髄内常在性マクロファージの増殖・分化機序2009

    • Author(s)
      岩崎之克, 柳澤伸彰, 大塚裕忠, 久光久, 真鍋厚史, 中村雅典
    • Organizer
      口腔組織培養学会
    • Place of Presentation
      昭和大学
    • Year and Date
      2009-12-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 歯髄内常在性マクロファージの増殖・分化機序2009

    • Author(s)
      岩崎之克, 柳澤伸彰, 大塚裕忠, 久光久, 真鍋厚史, 中村雅典
    • Organizer
      第51回歯科基礎医学会学術大会・総会
    • Related Report
      2011 Final Research Report
  • [Presentation] 造血・リンパ器官形成幹細胞窒素含有ビスホスホネート投与脾臓摘出マウスの肝臓における髄外造血について2009

    • Author(s)
      大塚裕忠、中村雅典
    • Organizer
      第39回日本免疫学会総会・学術集会
    • Related Report
      2011 Final Research Report
  • [Presentation] マウス唾液腺におけるPACAPレセプターの局在とPACAP経鼻投与による唾液分泌量の亢進

    • Author(s)
      野中直子, 中町智哉, 塩田清二, 中村雅典
    • Organizer
      第11回日本抗加齢医学会総会
    • Related Report
      2011 Final Research Report
  • [Book] 組織学・口腔組織学<第3版>2010

    • Author(s)
      磯川桂太郎・中村雅典・柳澤孝彰・渡邊弘樹
    • Publisher
      わかば出版
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Book] 組織学・口腔阻止苦学2010

    • Author(s)
      磯川桂太郎, 柳澤伸彰, 中村雅典, 渡邊弘樹
    • Total Pages
      388
    • Publisher
      わかば出版
    • Related Report
      2009 Annual Research Report
  • [Book] 口腔解剖学2009

    • Author(s)
      脇田稔・山下靖雄
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2011 Final Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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