| Project/Area Number |
21592344
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Tokyo Dental College |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KATO Tetsuo 東京歯科大学, 微生物学講座, 教授 (00159253)
KIMIZUKA Ryuta 東京歯科大学, 微生物学講座, 講師 (90287178)
INAGAKI Satoru 東京歯科大学, 微生物学講座, 助教 (20385165)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2009: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 口腔細菌学 / バイオフィルム / 歯周病 / 歯周病原性菌 / Synergistic effect / コンソーシア / Fucobacterium nucleatum / 共凝集 / Capnocytophaga ochracea / Prevotella intermedia / Prevotella nigrescence / Autoinducer-2 / 歯周炎 / red complex / プロテアーゼ / カテールアミン / ストレス / 歯周病原細菌 / Polymicrobial infection / Biofilm / Periodontopathic bacteria / Periodontitis / Fusobacterium nucleatum / Porphyromonas gingivalis / Invasion |
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| Research Abstract |
In this project, our goal was to investigate bacterial interaction in the process of biofilm formation to clarify the virulence of periodontopathic bacteria in dental plaque. In the process of colonization, P. gingivalis adhered to T. denticola by means of Hgp44, which is located on its surface. A synergistic effect was observed in co-culture of F. nucleatum and P. intermedia, C. ochracea, or P. gingivalis. In addition, invasion of epithelial cells by P. gingivalis was enhanced by co-infection with F. nucleatum or P. gingivalis. These results suggest that organization as consortia confers an advantage on periodontopathic bacteria in the formation of dental plaque.
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