| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Research Abstract |
Since primary sensory neurons(PSNs) in the mesencephalic trigeminal nucleus(MTN) are unique in receiving synaptic inputs onto various types of receptors such as a glutamatergic type-I AMPA receptor channel(AMPARCh), MTN neurons are thought to act not only as PSNs but also but also as interneurons independent of the activities of the peripheral receptors(Saito et al., 2006). In this study, we have demonstrated that in the rat MTN neurons, enhancement of h-current, caused by hyperpolarization of holding potential, activation of leak K^+ current or PKA activation, suppresses AMPARCh-mediated currents and might switch the MTN neuron to the PSN function mode.
|
