Role of a ubiquitin ligase for Sox9 on endochondral ossification and neurological disorder
| Project/Area Number |
21592359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
HATTORI Takako 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00228488)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIGAWA Masaharu 岡山大学, 大学院・医歯薬学総合研究科, 教授 (20112063)
KUBOTA Satoshi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90221936)
NISHIDA Takashi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (30322233)
AOYAMA Eriko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10432650)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Sox9 / ユビキチン / プロテオミクス解析 / 内軟骨性骨形成 / 神経疾患 / ユビキチンリガーゼ |
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| Research Abstract |
Sox9 is a master regulatory transcription factor of the SRY gene family regulating chondrogenesis as well as neural development. In this report, we identified a ubiquitin ligase which binds specifically and regulates cellular concentration of Sox9, and examined the role of the ubuquitin ligase on endochondral ossification as well as neurological disorder through controlling cellular concentration of Sox9.
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Report
(4 results)
Research Products
(72 results)
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[Journal Article] The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity.2011
Author(s)
Surmann-Schmitt, C., Sasaki, T., Hattori, T., Eitzinger, N., Schett, G., von der Mark, K., and Stock, M.
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Journal Title
J Cell Physiol.
Volume: (in press)
Related Report
Peer Reviewed
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[Journal Article] Sox9 is a major negative regulator of cartilage vascularisation, bone marrow formation, and endochondral ossification.2010
Author(s)
Takako Hattori, Catharina Mueller, Sonja Gebhard, Eva Bauer, Friederike Pausch, Britta Schlund, Michael Boesl, Andreas Hess, Cordula Surmann-Schmitt, Helga von der Mark, Benoit de Crombrugghe, Klaus von der Mark.
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Journal Title
Development
Volume: 137
Pages: 901-911
Related Report
Peer Reviewed
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[Journal Article] Sox9 is a major negative regulator of cartilage vascularisation, bone marrow formation, and endochondral ossification.2010
Author(s)
T Hattori, C Mueller, S Gebhard, E Bauer, F Pausch, B Schlund, M Boesl, A Hess, C-Schmitt, et al.
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Journal Title
Development 137
Pages: 901-911
Related Report
Peer Reviewed
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[Presentation] Characterization of the effect of CCN2 modules independently and in different combinations on chondrocytic cells2011
Author(s)
Abd El Kader, T., Kubota, S., Nishida, T., Hattori, T., et al.
Organizer
A meeting sponsored by the International CCN society
Place of Presentation
Vancouver, BC, Canada
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