| Project/Area Number |
21592359
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Functional basic dentistry
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| Research Institution | Okayama University |
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Principal Investigator |
HATTORI Takako 岡山大学, 大学院・医歯薬学総合研究科, 助教 (00228488)
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| Co-Investigator(Kenkyū-buntansha) |
TAKIGAWA Masaharu 岡山大学, 大学院・医歯薬学総合研究科, 教授 (20112063)
KUBOTA Satoshi 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90221936)
NISHIDA Takashi 岡山大学, 大学院・医歯薬学総合研究科, 助教 (30322233)
AOYAMA Eriko 岡山大学, 大学院・医歯薬学総合研究科, 助教 (10432650)
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| Project Period (FY) |
2009 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | Sox9 / ユビキチン / プロテオミクス解析 / 内軟骨性骨形成 / 神経疾患 / ユビキチンリガーゼ |
|---|
| Research Abstract |
Sox9 is a master regulatory transcription factor of the SRY gene family regulating chondrogenesis as well as neural development. In this report, we identified a ubiquitin ligase which binds specifically and regulates cellular concentration of Sox9, and examined the role of the ubuquitin ligase on endochondral ossification as well as neurological disorder through controlling cellular concentration of Sox9.
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