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Role of a ubiquitin ligase for Sox9 on endochondral ossification and neurological disorder

Research Project

Project/Area Number 21592359
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Functional basic dentistry
Research InstitutionOkayama University

Principal Investigator

HATTORI Takako  岡山大学, 大学院・医歯薬学総合研究科, 助教 (00228488)

Co-Investigator(Kenkyū-buntansha) TAKIGAWA Masaharu  岡山大学, 大学院・医歯薬学総合研究科, 教授 (20112063)
KUBOTA Satoshi  岡山大学, 大学院・医歯薬学総合研究科, 准教授 (90221936)
NISHIDA Takashi  岡山大学, 大学院・医歯薬学総合研究科, 助教 (30322233)
AOYAMA Eriko  岡山大学, 大学院・医歯薬学総合研究科, 助教 (10432650)
Project Period (FY) 2009 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2009: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
KeywordsSox9 / ユビキチン / プロテオミクス解析 / 内軟骨性骨形成 / 神経疾患 / ユビキチンリガーゼ
Research Abstract

Sox9 is a master regulatory transcription factor of the SRY gene family regulating chondrogenesis as well as neural development. In this report, we identified a ubiquitin ligase which binds specifically and regulates cellular concentration of Sox9, and examined the role of the ubuquitin ligase on endochondral ossification as well as neurological disorder through controlling cellular concentration of Sox9.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • 2009 Annual Research Report
  • Research Products

    (72 results)

All 2012 2011 2010 2009 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (57 results) Remarks (3 results) Patent(Industrial Property Rights) (4 results)

  • [Journal Article] The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity.2011

    • Author(s)
      Surmann-Schmitt, C., Sasaki, T., Hattori, T., Eitzinger, N., Schett, G., von der Mark, K., and Stock, M.
    • Journal Title

      J Cell Physiol.

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The Wnt antagonist Wif-1 interacts with CTGF and inhibits CTGF activity2011

    • Author(s)
      Surmann-Schmitt, C., Sasaki, T., Hattori, T., et al
    • Journal Title

      J Cell Physiol

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template2010

    • Author(s)
      Coustry, Francoise ; Oh, Chundo ; Hattori, Takako ; MAITY, SANKAR ; de Crombrugghe, Benoit and Yasuda, Hideyo
    • Journal Title

      Nucleic Acids Research

      Volume: 38 Pages: 6018-6028

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sox9 is a major negative regulator of cartilage vascularisation, bone marrow formation, and endochondral ossification.2010

    • Author(s)
      Takako Hattori, Catharina Mueller, Sonja Gebhard, Eva Bauer, Friederike Pausch, Britta Schlund, Michael Boesl, Andreas Hess, Cordula Surmann-Schmitt, Helga von der Mark, Benoit de Crombrugghe, Klaus von der Mark.
    • Journal Title

      Development

      Volume: 137 Pages: 901-911

    • Related Report
      2011 Final Research Report 2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template.2010

    • Author(s)
      Coustry Francoise, et al.
    • Journal Title

      Nucleic Acids Research

      Volume: 38 Pages: 6018-6028

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sox9 is a major negative regulator of cartilage vascularisation, bone marrow formation, and endochondral ossification.2010

    • Author(s)
      T Hattori, C Mueller, S Gebhard, E Bauer, F Pausch, B Schlund, M Boesl, A Hess, C-Schmitt, et al.
    • Journal Title

      Development 137

      Pages: 901-911

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan2009

    • Author(s)
      Aoyama E, Hattori T, Hoshijima M, Araki D, Nishida T, Kubota S, Takigawa M.
    • Journal Title

      Biochem J.

      Volume: 420(3) Pages: 413-20

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-terminal domains of CCN protein 2/connective tissue growth factor bind to aggrecan.2009

    • Author(s)
      Aoyama E, Hattori T, Hoshijima M, Araki D, Nishida T, Kubota S, Takigawa M.
    • Journal Title

      Biochem J. 420(3)

      Pages: 413-420

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Presentation] CCN2/CTGF-CCN3/NOVおよびCCN2-CCN2のダイマー形成が軟骨細胞の分化機能に及ぼす役割2012

    • Author(s)
      星島光博、服部高子、, 他
    • Organizer
      第25回日本軟骨代謝学会
    • Place of Presentation
      名古屋
    • Related Report
      2011 Final Research Report
  • [Presentation] 結合組織成長因子CCN2/CTGFは頭部神経堤由来の軟骨細胞分化に必須である2011

    • Author(s)
      服部高子、, 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] The low-density lipoprotein receptor related protein 1(LRP1) deficiency in the cartilage tissue leads to skeletal dysmorphisms2011

    • Author(s)
      Kawata, K., Kubota, S., Hattori, T., et al.
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2011 Final Research Report
  • [Presentation] Characterization of the effect of CCN2 modules independently and in different combinations on chondrocytic cells2011

    • Author(s)
      Abd El Kader, T., Kubota, S., Nishida, T., Hattori, T., et al.
    • Organizer
      A meeting sponsored by the International CCN society
    • Place of Presentation
      Vancouver, BC, Canada
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Assessment of combinational effect of independent CCN2 modules on chondrocytic cells2011

    • Author(s)
      Abd El Kdaer, T., Kubota, S., Nishida, T., Hattori, 他
    • Organizer
      第84回日本生化学会大会
    • Place of Presentation
      京都国際会議場、京都
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Roles of the heterotypic CCN2/CTGF-CCN3/NOV and homotypic CCN2-CCN2 interactions in matrix synthesis in chondrocytes2011

    • Author(s)
      Hoshijima, M., Hattori, T., et al.
    • Organizer
      The 33th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      San Diego, California
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Harmine, an inducer of CCN2/CTGF, promotes chondrogenesis and suppresses TNF-α-induced inflammatory response2011

    • Author(s)
      Emilio Satoshi Hara, Mitsuaki Ono, Satoshi Kubota, Wataru Sonoyama, Takako Hattori, 他
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場,大阪
    • Related Report
      2011 Final Research Report
  • [Presentation] Evaluation of independent and combinational effect of CCN2 modules on chondrocytic cells2011

    • Author(s)
      Tarek Abd El Kdaer, Satoshi Kubota, Takashi Nishida, Takako Hattori, 他
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場,大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] CCN2/CTGFのホモダイマー形成、およびCCN3/NOVとのヘテロダイマーの形成が軟骨細胞の基質合成に及ぼす役割2011

    • Author(s)
      星島光博、服部高子、, 他
    • Organizer
      第29回日本骨代謝学会
    • Place of Presentation
      大阪国際会議場,大阪
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] Cartilage-specific overexpression of CCN2/CTGF protects articular cartilage from age-related osteoarthritis-like changes2011

    • Author(s)
      Shinsuke Itoh, Takako Hattori, et al.
    • Organizer
      The 2011 Gordon Conference on Cartilage Biology and Pathology
    • Place of Presentation
      Ventura, CA
    • Related Report
      2011 Final Research Report
  • [Presentation] Cartilage-specific overexpression of CCN2/CTGF protects articular cartilage from age-related degenerative changes2011

    • Author(s)
      Shinsuke Itoh, Takako Hattori, et al.
    • Organizer
      連携機能を活用した口腔からQOL向上を目指す研究「国際シンポジウム」
    • Place of Presentation
      ホテルオークラ新潟,新潟
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] Role of the low-density lipoprotein receptor related protein 1 (LRP1)in CCN2 protein transportation in chondrocytes2011

    • Author(s)
      Kazumi Kawata, et al
    • Organizer
      第4回日本CCNファミリー研究会,若手国際学術奨励賞受賞講演
    • Place of Presentation
      アークホテル岡山、岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] Evaluation of independent and combinational effect of each of CCN2 modules on chondrocytic cells2011

    • Author(s)
      Tarek Abd El Kdaer, et al
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      アークホテル岡山、岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] Harmine, an inducer of CCN2/CTGF, promotes chondrogenesis and protection against TNF-α-induced inflammatory condition2011

    • Author(s)
      Emilio Satoshi Hara, et al
    • Organizer
      第4回日本CCNファミリー研究会
    • Place of Presentation
      アークホテル岡山、岡山
    • Related Report
      2011 Annual Research Report
  • [Presentation] Role of the low-density lipoprotein receptor related protein 1 (LRP1)in CCN2 protein transportation in chondrocytes2011

    • Author(s)
      Kawata, K., et al
    • Organizer
      Cell Signaling Networks 2011 : the 13th IUBMB Conference, the 1st PABMB Conference and the 3rd Meetings of the Signal Transduction Branch & Oxidative Stress Branches of SMB
    • Place of Presentation
      Merida, Yucatan, Mexico
    • Related Report
      2011 Annual Research Report
  • [Presentation] Harmine, an inducer of CCN2/CTGF, promotes chondrogenesis and suppresses TNF-α-induced inflammatory response2011

    • Author(s)
      Emilio Satoshi Hara, 他
    • Organizer
      第29回日本骨代謝学会、優秀ポスター
    • Place of Presentation
      大阪国際会議場,大阪
    • Related Report
      2011 Annual Research Report
  • [Presentation] The CCN2-inducer Harmine promotes chondrogenesis and protection against TNFa-induced inflammation2011

    • Author(s)
      Emilio Satoshi Hara, 他
    • Organizer
      59th meeting of the Japanese Association for Dental Research (JADR)-2011, Finalist of the Hatton Award competition
    • Place of Presentation
      広島国際会議場,広島
    • Related Report
      2011 Annual Research Report
  • [Presentation] CCN2/CTGFとCCN3/NOVのヘテロおよびホモダイマー形成が軟骨細胞の基質合成に及ぼす役割2011

    • Author(s)
      星島光博, 他
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      長良川国際会議場、岐阜
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス成長板におけるCa2+結合タンパクSorcinの局在について2011

    • Author(s)
      河合まりこ, 他
    • Organizer
      第53回歯科基礎医学会学術大会
    • Place of Presentation
      長良川国際会議場、岐阜
    • Related Report
      2011 Annual Research Report
  • [Presentation] The low-density lipoprotein receptor related protein 1 (LRP1)deficiency in the cartilage tissue leads to skeletal dysmorphisms2011

    • Author(s)
      Kawata, K., 他
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、神奈川
    • Related Report
      2011 Annual Research Report
  • [Presentation] Cartilage-specific overexpression of CCN2/CTGF protects articular cartilage from age-related osteoarthritis-like changes2011

    • Author(s)
      Shinsuke Itoh, Takako Hattori, et al.
    • Organizer
      The 2011 Gordon Conference on Cartilage Biology and Pathology
    • Place of Presentation
      Ventura Beach Marriott, Ventura, CA
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGF-CCN2およびCCN2-CCN3/NOVのダイマー形成が、軟骨細胞の基質合成に及ぼす役割2011

    • Author(s)
      星島光博、服部高子、青山絵理子、西田崇、山城隆、滝川正春
    • Organizer
      第24回日本軟骨代謝学会
    • Place of Presentation
      九州大学医学部百年講堂,福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟骨分化促進,抗炎症作用を持つ天然物由来低分子化合物Harmine2011

    • Author(s)
      Emilio Satoshi Hara, 大野充昭、久保田聡、園山亘, 服部高子, 滝川正春, 窪木拓男
    • Organizer
      第24回日本軟骨代謝学会
    • Place of Presentation
      九州大学医学部百年講堂,福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2単独モジュールタンパク質の複合適用が軟骨細胞に与える効果の解析2011

    • Author(s)
      Abd El Kader Ali Tarek Mohamad Mohamad, 他
    • Organizer
      第24回日本軟骨代謝学会
    • Place of Presentation
      九州大学医学部百年講堂,福岡
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFとCCN3/NOVの結合と軟骨細胞におけるその生理的意義2010

    • Author(s)
      星島光博、服部高子、青山絵理子、西田崇、山城隆、滝川正春
    • Organizer
      第1回骨バイオサイエンス研究会
    • Place of Presentation
      岡山コンベンションセンター、岡山
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFはマトリリン-3と結合して軟骨マトリックス成分のネットワーク形成を促進する2010

    • Author(s)
      服部高子、, 他
    • Organizer
      第33回日本分子生物学会年会・第83回日本生化学会大会合同大会
    • Place of Presentation
      神戸ポートアイランド,神戸
    • Related Report
      2011 Final Research Report
  • [Presentation] Cartilage-specific overexpression of ccn2/ctgf protects articular cartilage from age-related osteoarthritis-like changes2010

    • Author(s)
      Shinsuke Itoh, Takako Hattori, et al.
    • Organizer
      The sixth International Workshop on the CCN Family of Genes
    • Place of Presentation
      Slieve Donard Hotel, Newcastle, Northern Ireland
    • Related Report
      2011 Final Research Report
  • [Presentation] CCN2/CTGF Interacts with Matrilin-3 and Enhances Assembly of a Cartilage Matrix Protein and Filamentous Network2010

    • Author(s)
      Takako Hattori, et al.
    • Organizer
      The sixth International Workshop on the CCN Family of Genes
    • Place of Presentation
      Slieve Donard Hotel, Newcastle, Northern Ireland
    • Related Report
      2011 Final Research Report
  • [Presentation] Exportin-1によるCCN2/CTGFの核-細胞質間分子輸送とその生理的意義2010

    • Author(s)
      内田瑶子、服部高子、, 他
    • Organizer
      第52回歯科基礎医学会総会
    • Place of Presentation
      タワーホール船越、東京
    • Related Report
      2011 Final Research Report 2010 Annual Research Report
  • [Presentation] CCN2/CTGFはマトリリン. 3と結合して軟骨マトリックス成分のネットワーク形成を促進する2010

    • Author(s)
      服部高子、, 他
    • Organizer
      第42回日本結合組織学会学術大会・第57回マトリックス研究会大会合同学術集会
    • Place of Presentation
      秋田拠点センター・アルヴェ、秋田
    • Related Report
      2011 Final Research Report
  • [Presentation] CCN2/CTGFの核内移行とExportin-1による核.細胞質間分子輸送2010

    • Author(s)
      服部高子、, 他
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      京王プラザホテル、東京
    • Related Report
      2011 Final Research Report
  • [Presentation] Suppression of BMP-2-induced osteogenic differentiation of hBMSCs by TNF-α2010

    • Author(s)
      T. Fujisawa, M. Ueda, M. Ono, T. Hattori, et al.
    • Organizer
      The International Association for Dental Research
    • Place of Presentation
      Centre Convencions Internacional Barcelona, Barcelona, Spain
    • Related Report
      2011 Final Research Report
  • [Presentation] Sox9は血管侵入、骨髄形成および内軟骨性骨形成の最終段階を抑制する. Col10a1-BACトランスジェニックマウスを用いた解析-2010

    • Author(s)
      服部高子、, 他
    • Organizer
      第23回日本軟骨代謝学会,シンポジウム「軟骨分化の分子生物学」
    • Place of Presentation
      鹿児島県医師会館、鹿児島
    • Related Report
      2011 Final Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現による膝関節軟骨の加齢に伴う変性抑制効果2010

    • Author(s)
      伊藤慎将、服部高子、冨田奈緒、青山絵理子、山城隆、滝川正春
    • Organizer
      第23回日本軟骨代謝学会,シンポジウム「軟骨変性研究のカッティングエッジ」
    • Place of Presentation
      鹿児島県医師会館、鹿児島
    • Related Report
      2010 Annual Research Report
  • [Presentation] Sox9は血管侵入、骨髄形成および内軟骨性骨形成の最終段階を抑制する-Col10a1-BACトランスジェニックマウスを用いた解析-2010

    • Author(s)
      服部高子、池側広志、小郷絢子、滝川正春
    • Organizer
      第23回日本軟骨代謝学会,シンポジウム「軟骨分化の分子生物学」
    • Place of Presentation
      鹿児島県医師会館、鹿児島
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現による膝関節軟骨の加齢に伴う変性抑制効果2010

    • Author(s)
      伊藤慎将、服部高子、冨田奈緒、青山絵理子、山城隆、滝川正春
    • Organizer
      先端歯学スクール2010
    • Place of Presentation
      マホロバマインズ三浦,神奈川
    • Related Report
      2010 Annual Research Report
  • [Presentation] Suppression of BMP-2-induced osteogenic differentiation of hBMSCs by TNF-α.2010

    • Author(s)
      T.Fujisawa, M.Ueda, M.Ono, T.Hattori, W.Sonoyama, W.Sebald, T.Kuboki
    • Organizer
      The International Association for Dental Research
    • Place of Presentation
      Centre Convencions Internacional Barcelona, Barcelona, Spain
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGF Interacts with Matrilin-3 and Enhances Assembly of a Cartilage Matrix Protein and Filamentous Network.2010

    • Author(s)
      Takako Hattori, et al.
    • Organizer
      The sixth International Workshop on the CCN Family of Genes
    • Place of Presentation
      Slieve Donard Hotel, Newcastle, Northern Ireland
    • Related Report
      2010 Annual Research Report
  • [Presentation] Cartilage-specific overexpression of ccn2/ctgf protects articular cartilage from age-related osteoarthritis-like changes.2010

    • Author(s)
      Shinsuke Itoh, Takako Hattori, et al.
    • Organizer
      The sixth International Workshop on the CCN Family of Genes
    • Place of Presentation
      Slieve Donard Hotel, Newcastle, Northern Ireland
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFの核内移行とExportin-1による核-細胞質間分子輸送2010

    • Author(s)
      服部高子、星島光博、荒木大介、青山絵理子、滝川正春
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      京王プラザホテル、東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFのホモダイマー形成、およびCCN3/NOVとのヘテロダイマーの形成とそれらの軟骨細胞における生理作用2010

    • Author(s)
      星島光博、服部高子、青山絵理子、西田崇、山城隆、滝川正春
    • Organizer
      第28回日本骨代謝学会
    • Place of Presentation
      京王プラザホテル・東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFはマトリリン-3と結合して軟骨マトリックス成分のネットワーク形成を促進する2010

    • Author(s)
      服部高子, 他
    • Organizer
      第42回日本結合組織学会学術大会・第57回マトリックス研究会大会合同学術集会
    • Place of Presentation
      秋田拠点センター・アルヴェ、秋田
    • Related Report
      2010 Annual Research Report
  • [Presentation] 軟骨組織特異的CCN2/CTGF過剰発現によりマウスの膝関節軟骨は加齢後もより正常に近い形質を維持する2010

    • Author(s)
      伊藤慎将、服部高子、青山絵理子、山城隆、滝川正春
    • Organizer
      第52回歯科基礎医学会総会
    • Place of Presentation
      タワーホール船越、東京
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFのホモダイマー形成、およびCCN3/NOVとのヘテロダイマーの形成と、それらが軟骨細胞の基質合成に及ぼす役割2010

    • Author(s)
      星島光博、服部高子、青山絵理子、西田崇、山城隆,滝川正春
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸ポートアイランド,神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] CCN2/CTGFはマトリリン-3と結合して軟骨マトリックス成分のネットワーク形成を促進する2010

    • Author(s)
      服部高子, 他
    • Organizer
      BMB2010(第33回日本分子生物学会年会・第83回日本生化学会大会合同大会)
    • Place of Presentation
      神戸ポートアイランド,神戸
    • Related Report
      2010 Annual Research Report
  • [Presentation] トランスジェニックマウスを用いた軟骨機能分子のin vivo解析2009

    • Author(s)
      服部高子
    • Organizer
      岡山大学大学院医歯薬学総合研究科機能再生・再建科学専攻主催ミニシンポジウム
    • Place of Presentation
      岡山
    • Year and Date
      2009-08-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sox9 is a major negative regulator of cartilage vascularization2009

    • Author(s)
      Takako Hattori, et al.
    • Organizer
      2009 Gordon Conference on Cartilage Biology and Pathology
    • Place of Presentation
      Switzerland
    • Related Report
      2011 Final Research Report
  • [Presentation] Sox9 is a major negative regulator of cartilage vascularization2009

    • Author(s)
      T Hattori, S Gebhard, F Pausch, E Bauer, B Schlund, M Bosl, B de Crombrugghe, K yon der Mark
    • Organizer
      2009 Gordon Conference on Cartilage Biology and Pathology
    • Place of Presentation
      Les Diablerets, Switzerland
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現は関節軟骨を加齢に伴う変形性関節炎様変化から防御する2009

    • Author(s)
      伊藤慎将、服部高子、冨田奈緒、青山絵理子、山城隆、滝川正春
    • Organizer
      第27回日本骨代謝学会, 24. 第27回日本骨代謝学会優秀ポスター賞
    • Place of Presentation
      大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現は膝関節軟骨を加齢に伴う変性から保護する2009

    • Author(s)
      伊藤慎将、服部高子、青山絵理子、山城隆、滝川正春
    • Organizer
      第51回歯科基礎医学会学術大会
    • Place of Presentation
      新潟
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現マウスは膝関節軟骨の加齢性変化に抵抗性を示す(Cartilage-specific overexpression of CCN2/CTGF has anti-aging effects to protect knee joint cartilage from age-related degenerative changes.)2009

    • Author(s)
      伊藤慎将、服部高子、冨田奈緒、青山絵理子、山城隆、滝川正春
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] Sox9は軟骨において血管侵入を抑制する事によって内軟骨性骨形成の最終段階である骨髄形成を抑制する-Col10al-BACトランスジェニックマウスを用いた解析-2009

    • Author(s)
      服部高子、池側広志、小郷絢子、滝川正春
    • Organizer
      第82回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCN2/CTGFのExportin-1による核-細胞質間分子輸送2009

    • Author(s)
      服部高子、小郷絢子、圓城裕基、池側広志、荒木大介、星島光博、青山絵理子、滝川正春
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現マウスは膝関節軟骨の加齢に伴う変形性関節症様変化が仰制され、より正常に近い形質を維持する.2009

    • Author(s)
      伊藤慎将、服部高子、冨田奈緒、青山絵理子、山城隆、滝川正春、滝川正森
    • Organizer
      第32回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCN2の内軟骨性骨形成における生理的役割解明のためのin vivoモデルを用いた研究2009

    • Author(s)
      冨田奈緒, 服部高子, 伊藤慎将, 青山絵理子, 矢尾真弓, 山城隆, 滝川正春
    • Organizer
      国際医療セミナー、平成20年度大学院医歯薬学総合研究科(歯学系)研究スカラーシップ「QOL向上を目指す連携研究」
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] CCN2/CTGFはExportin-1と結合し, 細胞核内外を行き来する2009

    • Author(s)
      服部高子、小郷絢子、圓城裕基、池側広志、荒木大介、星島光博、青山絵理子、滝川正春
    • Organizer
      第三回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Presentation] 軟骨特異的CCN2/CTGF過剰発現マウスの膝関節軟骨は加齢後もより正常に近い形質を維持する2009

    • Author(s)
      伊藤慎将、服部高子、冨田奈緒、青山絵理子、山城隆、滝川正春
    • Organizer
      第三回日本CCNファミリー研究会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.dent.okayama-u.ac.jp/seika/index_sc_j.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.dent.okayama-u.ac.jp/seika/index_sc_j.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.dent.okayama-u.ac.jp/seika/index_sc_j.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] がんの治療又は予防剤2012

    • Inventor(s)
      滝川正春、服部高子、他
    • Industrial Property Rights Holder
      滝川正春、服部高子、他
    • Filing Date
      2012-01-12
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] アポトーシス誘導剤と併用されるがんの治療又は予防剤2012

    • Inventor(s)
      滝川正春、服部高子、他
    • Industrial Property Rights Holder
      滝川正春、服部高子、他
    • Filing Date
      2012-01-12
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] がんの治療又は予防剤2012

    • Inventor(s)
      滝川正春、服部高子, 他
    • Industrial Property Rights Holder
      滝川正春、服部高子, 他
    • Filing Date
      2012-01-20
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] アポトーシス誘導剤と併用されるがんの治療又は予防剤2012

    • Inventor(s)
      滝川正春、服部高子, 他
    • Industrial Property Rights Holder
      滝川正春、服部高子, 他
    • Filing Date
      2012-01-20
    • Related Report
      2011 Annual Research Report

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Published: 2009-04-01   Modified: 2016-04-21  

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